ACP journal club最新文献

{"title":"Review: rifaximin is equally or more effective than other antibiotics and lactulose for hepatic encephalopathy.","authors":"Joe Alcorn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 5","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2008-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27842835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eradication of H. pylori after endoscopic resection for early gastric cancer reduced risk for metachronous gastric cancer.","authors":"Vincent Wai-Sun Wong, Francis Ka-Leung Chan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 5","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2008-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27842836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess mortality after HIV seroconversion has greatly decreased in the past 10 years.","authors":"Richard D Moore","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 5","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2008-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027745/pdf/nihms977709.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27842839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence in context: one person's poison is another's acceptable risk.","authors":"R Brian Haynes, Lawrence E Hart","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 5","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"2008-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27842916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tibolone reduced risk for fractures and breast cancer but increased risk for stroke in older women with osteoporosis.","authors":"Robert P Kauffman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 5","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2008-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27842832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review: anticoagulation with INRs less than 2 or between 3 and 5 increases risk for thromboembolic or hemorrhagic events.","authors":"Anne Holbrook","doi":"10.7326/0003-4819-149-10-200811180-02005","DOIUrl":"https://doi.org/10.7326/0003-4819-149-10-200811180-02005","url":null,"abstract":"Question What is the effect of anticoagulation intensity on risk for thromboembolism or hemorrhage in patients taking oral anticoagulants (OAs)? Review scope Studies selected evaluated OA therapy for various indications and reported the number of outcome events and corresponding person-years of observation for 3 discrete ranges of international normalized ratios (INRs) (<2, 2 to 3, and >3). Patients taking both antiplatelet and anticoagulant medications were excluded. Outcomes were thromboembolism and hemorrhage; if severity of events was reported, those of minor severity were not included. Review methods MEDLINE, EMBASE/Excerpta Medica, CINAHL, and Cochrane Central Register of Controlled Trials (all to 2006), and Science Citation Index were searched for studies. 19 studies (n =80713, 56% men, mean follow-up 0.2 to 4.6 y) met the selection criteria: 10 retrospective cohort studies, 3 prospective cohort studies, and 6 randomized controlled trials (RCTs). 17 studies reported hemorrhagic events, including those that required hospitalization, blood transfusion, or surgery, or were intracranial or fatal; 16 reported thromboembolic events, including stroke, myocardial infarction, and systemic emboli. The meta-analysis compared outcomes by achieved INR ranges (reference INR range 2 to 3). Main results There were 98900 patient-years of follow-up across all trials. Meta-analysis showed that anticoagulation with INRs >3 increased risk for hemorrhage and anticoagulation with INRs <2 or >5 increased risk for thromboembolism (Table). When hemorrhage and thromboembolism were combined, anticoagulation with INRs <2, between 3 and 5, and >5 increased risk compared with the reference range (2 to 3) (Table). Significant heterogeneity between studies was detected. Conclusion In patients taking oral anticoagulants, anticoagulation with international normalized ratios <2 or between 3 and 5 increases risk for hemorrhage or thromboembolism compared with a reference range of 2 to 3. Anticoagulation with achieved international normalized ratios (INRs) in patients taking oral anticoagulants* Outcomes at mean 0.2 to 4.6 y follow-up Number of trials (n) Absolute risk/y (95% CI) INR <2 INR 2 to 3 INR 3 to 5 INR >5 Hemorrhage 17 (77913) 1.5% (0.7 to 3.0) 1.4% (0.9 to 2.3) 3.7% (2.2 to 6.3) 30% (15 to 61) Thromboembolism 16 (34706) 9% (6 to 13) 2.6% (1.8 to 3.6) 2.3% (1.5 to 3.4) 7% (3 to 14) Hemorrhage or thromboembolism 14 (31906) 11% (7 to 17) 4.3% (3.0 to 6.3) 7% (5 to 11) 52% (30 to 92) *Abbreviations defined in Glossary. Commentary The main conclusion of the meta-analysis by Oake and colleaguesthat optimal INR range is 2 to 3 across multiple indications for OA therapyis not controversial. The most recent authoritative guideline on OA use also suggests that dosing to an INR target of 2 to 3 is the safest and most effective range for most indications (1). The finding that rates of hemorrhage approximately double at an INR range of 3 to 5 and increase by as much as 10 to 20 ","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 5","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2008-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27842827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding in knee arthroplasty.","authors":"Pieter W Kamphuisen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 4","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27805852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review: spot protein-creatinine ratio has moderate diagnostic performance for proteinuria in pregnant women with hypertension.","authors":"Christopher J Robinson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 4","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27805860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A model was sensitive but not specific for screening for tuberculosis in contact patients.","authors":"Dick Menzies","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 4","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27805861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding or other safety outcomes in hip arthroplasty.","authors":"Pieter W Kamphuisen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79388,"journal":{"name":"ACP journal club","volume":"149 4","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27805853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}