Transplantation science最新文献_第3页

Etiology and pathogenesis of tumors occurring after organ transplantation. 器官移植后肿瘤的病因及发病机制。

Transplantation science Pub Date : 1994-09-01

S A Gruber, A J Matas

引用次数: 0

Donor mononuclear cell infusions as therapy for B-cell lymphoproliferative disorder following allogeneic bone marrow transplant. 供体单核细胞输注治疗同种异体骨髓移植后b淋巴细胞增生性疾病。

Transplantation science Pub Date : 1994-09-01

D L Porter, G J Orloff, J H Antin

引用次数: 0

Secondary malignancies after marrow transplantation for leukemia or aplastic anemia. 白血病或再生障碍性贫血骨髓移植后继发恶性肿瘤。

Transplantation science Pub Date : 1994-01-01 DOI: 10.1097/00007890-199405270-00001

R. Witherspoon, H. Deeg, R. Storb

{"title":"Secondary malignancies after marrow transplantation for leukemia or aplastic anemia.","authors":"R. Witherspoon, H. Deeg, R. Storb","doi":"10.1097/00007890-199405270-00001","DOIUrl":"https://doi.org/10.1097/00007890-199405270-00001","url":null,"abstract":"We conclude that the most common secondary cancers which develop after marrow transplantation are lympho-proliferative disorders and solid tumors. The consequences of the secondary malignancies are serious, with more than 90% of the patients with non-Hodgkin lymphomas associated with EBV infection and more than 75% of the patients with solid tumors dying despite treatment. Secondary leukemia developing in donor T-s is rare, but was fatal in all cases. EBV infection plays a major role in leading to the non-Hodgkin lymphomas in a setting of immune dysregulation from ATG or anti-T-cell monoclonal antibody treatment of acute GVHD. Other factors are also important for development of non-Hodgkin lymphoma and include T-cell depletion of donor marrow and HLA-mismatching between donor and recipient, known to lead to dysregulation of T-lymphocyte function. These factors set up an environment of proliferative stimuli which cannot be controlled by the recovering immune system, setting the stage for a secondary cancer. The role of irradiation is becoming more prominent in association with solid tumors, particularly in aplastic anemia patients conditioned with irradiation. The final event of tumor expression is most likely the result of a cascade of events, perhaps initiated with the conditioning regimen or with stimuli to proliferation, which, after later signals, leads to malignant transformation. For lymphoproliferative disorders, the time of latency is shorter than for solid tumors, suggesting a different molecular mechanism. The incidence of oncogene expression or mutation in tumor suppressor genes in these solid tumor patients has not been investigated.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":79385,"journal":{"name":"Transplantation science","volume":"4 1 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00007890-199405270-00001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61514290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Reversal of Graft-Versus-Host Disease with Infusion of Stored Autologous Bone Marrow Cells Following Combined Liver-Bone Marrow Allotransplantation in Man. 人肝-骨髓联合移植后注入储存的自体骨髓细胞逆转移植物抗宿主病

Transplantation science Pub Date : 1993-04-01

Camillo Ricordi, Andreas G Tzakis, Anthony J Demetris, Adriana Zeevi, Witold B Rybka, Michael A Nalesnik, Ferdinand O Ukah, Paulo A C Fontes, Edward D Ball, Thomas E Starzl

引用次数: 0

The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction. 细胞迁移和嵌合在器官移植接受和耐受诱导中的作用。

Transplantation science Pub Date : 1993-04-01

Thomas E Starzl, Anthony J Demetris, Massimo Trucco, Camillo Ricordi, Noriko Murase, Angus W Thomson

引用次数: 0

Induction of Pancreatic Islet Graft Acceptance: The Role of Antigen Presenting Cells. 胰岛移植接受的诱导:抗原呈递细胞的作用。

Transplantation science Pub Date : 1992-04-01

Camillo Ricordi, Suzanne T Ildstad, Thomas E Starzl

引用次数: 0