The Journal of pediatric endocrinology最新文献_第9页

Neurotransmitter control of growth hormone secretion in children after cranial radiation therapy. 脑放射治疗后儿童生长激素分泌的神经递质调控。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

E V Jorgensen, I D Schwartz, E Hvizdala, J Barbosa, S Phuphanich, D I Shulman, A W Root, J Estrada, C S Hu, B B Bercu

{"title":"Neurotransmitter control of growth hormone secretion in children after cranial radiation therapy.","authors":"E V Jorgensen, I D Schwartz, E Hvizdala, J Barbosa, S Phuphanich, D I Shulman, A W Root, J Estrada, C S Hu, B B Bercu","doi":"","DOIUrl":"","url":null,"abstract":"Cranial radiation for childhood cancer can cause growth hormone deficiency (GHD), usually due to hypothalamic rather than pituitary dysfunction. To investigate whether this hypothalamic dysfunction is secondary to altered neurotransmitter input from other brain centers, we used neurotransmitter-excitatory substances to study the GH secretory response in 17 children who had received 12 to 60 Grey (Gy) to the cranium and 40 short children with normal endocrine function. As expected, the irradiated children had decreased mean GH secretion in response to insulin-induced hypoglycemia and arginine infusion, and decreased mean 24 hour GH concentrations, compared to the control group. In contrast, the two groups had similar GH secretory responses to GHRH stimulation and somatostatin suppression. Assessment of neurotransmitter pathways in the irradiated children revealed significantly lower mean peak GH concentrations in response to 5 of the 6 substances tested compared to control children: alpha-adrenergic stimulation (clonidine), beta-adrenergic blockade (propranolol), cholinergic stimulation, dopaminergic stimulation (L-dopa), and GABA-ergic stimulation (valproic acid). Results of serotonergic stimulation (L-tryptophan) were not statistically significant. Eleven patients who had abnormal GH secretion underwent 4 or more tests with neurotransmitter-stimulatory agents; 3 patients had peak GH concentrations of < 2.5 micrograms/l to all tests, whereas 4 patients had a peak GH concentration of > or = 7 micrograms/l to one or more tests but < 5 micrograms/l to one or more other tests. These observations suggest that radiation damage may sometimes spare growth hormone-releasing hormone (GHRH) and somatostatin secretion while affecting neurotransmitter pathways. We postulate that the hierarchy of sensitivity to radiation damage may be hypothalamic and extra-hypothalamic neurotransmitters > hypothalamic GHRH and/or somatostatin secretion > pituitary GH secretion.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"6 2","pages":"131-42"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19095150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemia in the neonate. 新生儿低血糖症。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

M Cornblath, R Schwartz

引用次数: 0

An enzyme-linked immunosorbent assay for urinary albumin in patients with insulin-dependent diabetes mellitus. 胰岛素依赖型糖尿病患者尿白蛋白的酶联免疫吸附测定。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

N Igarashi, R Takeya, T Sato

引用次数: 0

The evaluation of 24-hour spontaneous GH secretion in short children: relationship between mean concentration and pulsatile parameters. 矮个子儿童24小时自发性生长激素分泌的评价:平均浓度与搏动参数的关系。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

G Saggese, G Cesaretti, C Carlotti, C Cioni, C Bracaloni

{"title":"The evaluation of 24-hour spontaneous GH secretion in short children: relationship between mean concentration and pulsatile parameters.","authors":"G Saggese, G Cesaretti, C Carlotti, C Cioni, C Bracaloni","doi":"","DOIUrl":"","url":null,"abstract":"In 116 short children (height < -1.6 SDs), the authors examined GH secretion over 24 hours, by taking blood samples every 20 min and performing an electroencephalographic sleep control. The following GH parameters were evaluated: 24-h mean GH concentration (MGHC); maximum GH peak during the initial cycle of sleep (iMGHP), the nocturnal 12 h (nMGHP) or diurnal 12 h (dMGHP), the number of GH pulses over 24 h (NP), or nocturnal 12 h (nNP) or diurnal 12 h (dNP), the mean pulse amplitude over 24 h (MPA), or nocturnal 12 h (nMPA) or diurnal 12 h (dMPA). The subjects were divided into 3 groups: group 1, 12 subjects with low responses to provocative tests and MGHC < 3 ng/ml; group 2, 36 subjects with normal responses to provocative tests and MGHC < 3 ng/ml; group 3, 68 subjects with MGHC > 3 ng/ml. MGHC was highly correlated (p < 0.001) with iMGHP (r = 0.80), nMGHP (r = 0.82), dMGHP (r = 0.59), MPA (r = 0.85), nMPA (r = 0.86), dMPA (r = 0.56), NP (r = 0.70), nNP (r = 0.68), dNP (r = 0.46). By the analysis of the regression equations, the values corresponding to 3 ng/ml for MGHC were 11.08 ng/ml for iMGHP, 11.66 ng/ml for nMGHP, 5.21 ng/ml for dMGHP, 7.29 ng/ml for MPA, 8.40 ng/ml for nMPA, 4.25 ng/ml for dMPA, 3.2 for NP, 2.41 for nNP and 0.78 for dNP. By using these values as cut-off points, the diagnostic accuracy yielded 83.6% for iMGHP, 84.5% for nMGHP, 69.8% for dMGHP, 92.2% for MPA, 90.5% for nMPA, 81.9% for dMPA, 80.2% for NP, 77.6% for nNP, 71.5% for dNP. In conclusion, we found a strong correlation between mean GH secretion over 24 h and the number or amplitude of pulses: particularly, nocturnal pulsatile GH parameters show a higher correlation in comparison with diurnal pulsatile GH parameters, so that the examination of GH values during nocturnal hours may be considered a reliable index of GH secretory status.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"6 2","pages":"143-52"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19334388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Final heights in 45,X Turner's syndrome with spontaneous sexual development. Review of European and American reports. 最终身高45岁，X特纳综合症伴自发性发育。审查欧洲和美国的报告。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

L A Page

{"title":"Final heights in 45,X Turner's syndrome with spontaneous sexual development. Review of European and American reports.","authors":"L A Page","doi":"","DOIUrl":"","url":null,"abstract":"Study objective: To assess the effect of endogenous estrogen secretion on the final heights of patients with 45,X Turner's syndrome.Design: European and American reports of patients with 45,X Turner's syndrome and spontaneous sexual maturation in which final heights were available were analyzed and compared with existing norms for untreated patients with Turner's syndrome. Subgroups of patients were compared as a means of distinguishing low from normal endogenous estrogen exposure, and the effect of the age of menarche was assessed.Patients: Twenty-three cases were collected, including eight who became pregnant. One had full somatic maturation but did not menstruate. RESULTS OF ANALYSES: Mean height of all 23 patients was 140.8 cm +/- 8.07 (s.d.) vs 143.1 cm +/- 6.0 (p = 0.035) for literature norms for Turner's syndrome. Mean height of those who achieved pregnancy was 138.6 cm +/- 8.21 (p = 0.035 vs literature norm); of those with normal gonadotropins 137.5 cm +/- 6.03; and of those with high gonadotropins 139.2 cm +/- 1.44 (p = 0.374). Age of menarche was available in 21 and showed no correlation with final height.Conclusions: Physiological and subphysiological endogenous secretion of estrogen in Turner's syndrome does not increase final height, suggesting that even low-dose exogenous estrogen would not increase ultimate stature in these patients.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"6 2","pages":"153-8"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19334389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and inmunogenetics in recently diagnosed Venezuelan children with insulin-dependent diabetes mellitus. 委内瑞拉新近确诊的胰岛素依赖型糖尿病儿童的流行病学和免疫遗传学

The Journal of pediatric endocrinology Pub Date : 1993-04-01

P Gunczler, R Lanes, Z Layrisse, B Esparza, R Salas, L Hernández, A Arnaiz-Villena

{"title":"Epidemiology and inmunogenetics in recently diagnosed Venezuelan children with insulin-dependent diabetes mellitus.","authors":"P Gunczler, R Lanes, Z Layrisse, B Esparza, R Salas, L Hernández, A Arnaiz-Villena","doi":"","DOIUrl":"","url":null,"abstract":"Genetic and immunological markers in children with Type I diabetes have not been studied previously in Venezuela. We evaluated 91 newly diagnosed IDDM children mean age 7.8 +/- 4.5 (range 0.8-20.8 years), 51 females and 40 males. Eleven percent of first degree relatives had a family history of Type I IDDM; 56.7% had had upper respiratory infection prior to diagnosis and 12.7% had had either mumps or varicella. Peak incidence of disease was found in February and March and August to October. Eighty seven percent had HLA-DR3 and/or DR4 vs 36% of the Venezuelan general population; 81.6% were HLA-DQW2 and/or HLA-DQW8. We found 55.9% to have positive islet cell antibodies (ICA) with 4 of these having a positive complement fixation test. Three patients (7.9%) were found to have positive insulin autoantibodies. Only 3 out of 11 HLA-identical siblings had positive ICAs, while none had positive insulin autoantibodies. One of them also had a positive complement fixation test; this subject developed IDDM. No positive serotypes for enterovirus (Coxsackie-B) were found in our patients, but we detected 11 cases with elevated titers for cytomegalovirus antibodies and positive antibodies for measles, mumps, herpes and varicella were found in some children. These data confirm that most of our Type I diabetics carry HLA-DR3 or DR4 and that the heterozygous DR3/DR4 phenotype is markedly increased in this population; they also indicate that DR3QW2 and DR4QW8 are associated with increased risk in our population.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"6 2","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19380426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report: familial hypoalphalipoproteinemia. 家族性低脂蛋白血症1例。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

E Tamugur, B Oren, A Büyükgebiz

引用次数: 0

Cushing's disease presenting as pubertal arrest. 库欣氏病表现为青春期停滞。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

Z Zadik, M Cooper, M Chen, N Stern

引用次数: 0

Auxological and biochemical parameters in assessing treatment of infants and toddlers with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 21-羟化酶缺乏症对婴幼儿先天性肾上腺增生的生理生化参数评价。

The Journal of pediatric endocrinology Pub Date : 1993-04-01

S Einaudi, R Lala, A Corrias, P Matarazzo, S Pagliardini, C de Sanctis