The Journal of pediatric endocrinology最新文献_第3页

Growth hormone (GH) and the immune system: impaired phagocytic function in children with idiopathic GH deficiency is corrected by treatment with biosynthetic GH. 生长激素(GH)和免疫系统:特发性GH缺乏儿童的吞噬功能受损可通过生物合成GH治疗得到纠正。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.245

R Manfredi, F Tumietto, L Azzaroli, A Zucchini, F Chiodo, G Manfredi

{"title":"Growth hormone (GH) and the immune system: impaired phagocytic function in children with idiopathic GH deficiency is corrected by treatment with biosynthetic GH.","authors":"R Manfredi, F Tumietto, L Azzaroli, A Zucchini, F Chiodo, G Manfredi","doi":"10.1515/jpem.1994.7.3.245","DOIUrl":"https://doi.org/10.1515/jpem.1994.7.3.245","url":null,"abstract":"Thirty-seven prepubertal children evaluated for severe growth retardation were studied by assessment of total granulocyte, monocyte and lymphocyte count, lymphocyte subsets CD3+, CD3+Dr+, CD3+Dr-, CD4+, CD8+, CD8+CD57+, CD8+CD57-, CD16+, CD20+ and CD23+, serum immunoglobulin concentrations, and phagocytic activity of circulating neutrophils and monocytes (by a flow cytometric assay). Idiopathic GH deficiency was diagnosed in 21 of 37 patients; the remaining 16 healthy subjects served as controls. Fourteen patients received biosynthetic GH (rhGH), and their immune parameters were assessed at baseline and after 6 months of therapy. Phagocytic function mediated by both polymorphonuclears and monocytes was significantly impaired in GH-deficient subjects compared to controls (p < 0.003 for neutrophils, p < 0.007 for monocytes), while a significant increase of phagocytic activity was obtained during long-term rhGH replacement therapy (p < 0.02 for neutrophils, p < 0.001 for monocytes), thus suggesting that GH may affect the functional activity of circulating phagocyte cells. No significant differences were found in total granulocyte, monocyte and lymphocyte counts, T- and B-lymphocyte subsets and immunoglobulin levels, between GH-deficient patients and controls, and between values observed before and during rhGH substitution treatment.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"7 3","pages":"245-51"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1994.7.3.245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18819151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Abnormal alpha cell hypoglycemic recognition in children with insulin dependent diabetes mellitus (IDDM). 胰岛素依赖型糖尿病(IDDM)患儿α细胞低血糖识别异常。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.225

R P Hoffman, C Singer-Granick, A L Drash, D J Becker

{"title":"Abnormal alpha cell hypoglycemic recognition in children with insulin dependent diabetes mellitus (IDDM).","authors":"R P Hoffman, C Singer-Granick, A L Drash, D J Becker","doi":"10.1515/jpem.1994.7.3.225","DOIUrl":"https://doi.org/10.1515/jpem.1994.7.3.225","url":null,"abstract":"Children with IDDM have diminished glucagon responses to hypoglycemia. We evaluated possible mechanisms in 60 children and adolescents with IDDM (age 15.4 +/- 2.6 years, duration 7.8 +/- 3.5 years [mean +/- SD]) and without diabetic complications. These were: 1) suppression by hyperinsulinism, 2) autonomic neuropathy, 3) a pan-islet cell defect, and 4) a glucotoxic effect. Glucagon and pancreatic polypeptide responses to hypoglycemia (insulin bolus 0.15-0.75 U/kg) were studied after insulin withdrawal and 3 days of intensive insulin therapy. Responses to arginine and mixed meal were also studied. The control group consisted of children with non-growth hormone deficient short stature. IDDM children had lower glucagon responses to hypoglycemia than controls (p < 0.001), the response to arginine did not differ from controls, and was greater than the response to hypoglycemia (p < 0.001). Responses to hypoglycemia after insulin withdrawal and intensive therapy did not differ. Basal pancreatic polypeptide levels were lower in IDDM than in controls (p < 0.05) but responses to hypoglycemia did not differ between groups. Thus the diminished glucagon response to hypoglycemia reflects a defect in hypoglycemic recognition or response by the alpha cells.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"7 3","pages":"225-34"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1994.7.3.225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18820618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Adult height exceeding target height in a patient with congenital panhypopituitarism diagnosed after the age of 25 years. 25岁以后诊断为先天性垂体功能减退症的成人身高超过目标身高1例。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.269

T Arrigo, G Crisafulli, A Salamone, D Cucinotta, F De Luca

引用次数: 3

Impaired counterregulatory hormone responses to hypoglycemia in children and adolescents with new onset IDDM. 新发IDDM儿童和青少年对低血糖的反调节激素反应受损。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.235

R P Hoffman, S Arslanian, A L Drash, D J Becker

{"title":"Impaired counterregulatory hormone responses to hypoglycemia in children and adolescents with new onset IDDM.","authors":"R P Hoffman, S Arslanian, A L Drash, D J Becker","doi":"10.1515/jpem.1994.7.3.235","DOIUrl":"https://doi.org/10.1515/jpem.1994.7.3.235","url":null,"abstract":"Children with long-standing IDDM have impaired counterregulatory responses to hypoglycemia. To determine whether children with new onset IDDM also have altered counterregulation, we studied the counterregulatory responses to hypoglycemia in twenty children with new onset IDDM (5-6 days, age 12.6 +/- 2.9 yr, mean +/- SD), and compared these responses to 47 subjects with long-standing IDDM (duration 7.8 +/- 3.6 yr, age 15.3 +/- 2.5 yr) and 21 controls (age 14.2 +/- 2.8 yr). Six new onset subjects were restudied three months later during their remission. Glucose nadir in new onset (2.7 +/- 0.1 mmol.l-1) was similar to controls (2.4 +/- 0.1 mmol.l-1), but was higher than in long-standing IDDM (2.2 +/- 0.1 mmol.l-1). Both groups of diabetic subjects had lower glucagon responses to hypoglycemia than controls (p < 0.005). Glucagon responses in new and long-standing diabetes did not differ. Epinephrine was diminished in new IDDM compared to controls (p < 0.01). Glucose recovery was faster in new onset than in long-standing IDDM (p < 0.001) and the same as in controls. Responses remained diminished 3 months after diagnosis despite increased C-peptide and lower glycosylated hemoglobin. Thus, children with IDDM have diminished counterregulatory responses to hypoglycemia at diagnosis, that are similar to those in long-standing IDDM. The reasons for this impairment and its clinical application in childhood require further investigation.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"7 3","pages":"235-44"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1994.7.3.235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18819152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Thyroid function in children with perinatally acquired antibodies to human immunodeficiency virus. 围产期获得性人类免疫缺陷病毒抗体儿童的甲状腺功能。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.201

S L Blethen, S Nachman, F I Chasalow

引用次数: 7

Neonatal sex-steroid hormones and physical size at four years. 新生儿四岁时的性类固醇激素和体格大小。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.253

C N Jacklin, C McBride, P McCrory, L Gallahan

引用次数: 8

Growth follow-up in 100 children with congenital hypothyroidism before and during treatment. 100例先天性甲状腺功能减退症患儿治疗前后的生长随访。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.211

A Chiesa, L Gruñeiro de Papendieck, A Keselman, J J Heinrich, C Bergada

{"title":"Growth follow-up in 100 children with congenital hypothyroidism before and during treatment.","authors":"A Chiesa, L Gruñeiro de Papendieck, A Keselman, J J Heinrich, C Bergada","doi":"10.1515/jpem.1994.7.3.211","DOIUrl":"https://doi.org/10.1515/jpem.1994.7.3.211","url":null,"abstract":"In order to assess the influence of age at onset of treatment on subsequent growth, height, weight, head circumference (HC) and bone age as estimated by Greulich-Pyle and TW2-RUS methods, 100 children with congenital hypothyroidism (CH) were studied before and during adequate treatment up to 5 years of age. The patients were divided into five groups according to age at the start of treatment: Group 1: < 2 months (n = 26); Group 2: 2-3 months (n = 13); Group 3: 3-6 months (n = 21); Group 4: 6-12 months (n = 20); Group 5: 12-24 months (n = 20). Before treatment, groups 1 and 2 differed significantly from the others in height (p < 0.001). With hormone therapy, catch-up growth was observed in groups 3 to 5, but at age 5 years no differences were found between groups. In all groups, height at 5 years of age correlated significantly with children's midparental height (p < 0.002). Bone age was initially retarded in groups 3 to 5, but approximated the chronological age by age 5 years. Initially, HC was less affected than height and remained relatively larger up to age 5 years in all groups. These findings show that thyroid hormone replacement in CH as late as 24 months corrects the short stature and delayed bone age by age 5 years.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"7 3","pages":"211-7"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1994.7.3.211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18819149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Prenatal diagnosis and treatment of congenital adrenal hyperplasia. 先天性肾上腺增生症的产前诊断与治疗。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.183

P W Speiser, M I New

引用次数: 13

Endocrine studies in children with myelomeningocele. 脊髓脊膜膨出儿童的内分泌研究。

The Journal of pediatric endocrinology Pub Date : 1994-07-01 DOI: 10.1515/jpem.1994.7.3.219

L Perrone, D Del Gaizo, E D'Angelo, L Rea, G Di Manso, R Del Gado

{"title":"Endocrine studies in children with myelomeningocele.","authors":"L Perrone, D Del Gaizo, E D'Angelo, L Rea, G Di Manso, R Del Gado","doi":"10.1515/jpem.1994.7.3.219","DOIUrl":"https://doi.org/10.1515/jpem.1994.7.3.219","url":null,"abstract":"Pituitary-hypothalamic abnormalities due to impaired cerebrospinal fluid circulation have long been recognized. The aim of this study was to assess pituitary, thyroid, adrenal, and gonadal function in 46 prepubertal (22 M and 24 F) and 10 pubertal (4 M and 6 F) subjects with myelomeningocele (MMC). Basal serum levels of FT3, FT4, TSH, PRL, LH, FSH, T or E2, cortisol, 17-OH-P and DHEA-S were measured by routine radio-immunoassay methods. Twenty-two prepubertal patients had a TRH test for TSH and PRL evaluation, and eight underwent a GnRH test. Three patients presented with precocious puberty. Six subjects had modest elevations of serum TSH together with normal free thyroid hormone levels. In three cases, TSH responses to TRH were significantly exaggerated and prolonged: in two patients, TSH responses were delayed. The mean basal plasma FSH level in females with ventriculo-peritoneal shunt was significantly higher than in controls. In six cases FSH responses to GnRH were significantly higher than in controls. Both basal and stimulated PRL levels were elevated in patients with shunts; in patients without shunts, basal PRL was normal, but peak PRL levels following TRH stimulation were elevated. Our data show an abnormal hypothalamic-pituitary function in MMC subjects. These findings reinforce the importance of physical examination, hormonal evaluation and follow-up of pubertal development in patients with myelomeningocele.","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"7 3","pages":"219-23"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1994.7.3.219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18820617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Secular changes in growth of Japanese children. 日本儿童成长的长期变化。

The Journal of pediatric endocrinology Pub Date : 1994-04-01 DOI: 10.1515/jpem.1994.7.2.163

M Takaishi

引用次数: 39