Seminars in gastrointestinal disease最新文献_第9页

Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology. 脑肠轴与粘膜免疫:粘膜心理神经免疫学的观点。

Seminars in gastrointestinal disease Pub Date : 1999-01-01

F Shanahan

{"title":"Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.","authors":"F Shanahan","doi":"","DOIUrl":"","url":null,"abstract":"The role of the brain-gut axis has traditionally been investigated in relation to intestinal motility, secretion, and vascularity. More recently, the concept of brain-gut dialogue has extended to the relationship between the nervous system and mucosal immune function. There is compelling evidence for a reciprocal or bi-directional communication between the immune system and the neuroendocrine system. This is mediated, in part, by shared ligands (chemical messengers) and receptors that are common to the immune and nervous systems. Although the concept of psychoneuroimmunology and neuroimmune cross-talk has been studied primarily in the context of the systemic immune system, it is likely to have special significance in the gut. The mucosal immune system is anatomically, functionally, and operationally distinct from the systemic immune system and is subject to independent regulatory signals. Furthermore, the intestinal mucosal immune system operates in a local milieu that depends on a dense innervation for its integrity, with juxtaposition of neuroendocrine cells and mucosal immune cells. An overview of evidence for the biologic plausibility of a brain-gut-immune axis is presented and its potential relevance to mucosal inflammatory disorders is discussed.","PeriodicalId":79377,"journal":{"name":"Seminars in gastrointestinal disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20938969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and mind-body impact on the course of inflammatory bowel diseases. 压力和身心对炎症性肠病病程的影响。

Seminars in gastrointestinal disease Pub Date : 1999-01-01

P A Anton

引用次数: 0

Psychoneuroimmunology update. 心理神经免疫学更新。

Seminars in gastrointestinal disease Pub Date : 1999-01-01

M E Kemeny, T L Gruenewald

{"title":"Psychoneuroimmunology update.","authors":"M E Kemeny, T L Gruenewald","doi":"","DOIUrl":"","url":null,"abstract":"Psychoneuroimmunology is the scientific field that investigates linkages between the brain, behavior, and the immune system and the implications of these linkages for physical health and disease. Recent evidence suggests that both naturalistic and laboratory stressors can alter enumerative and functional aspects of the human immune system. Chronic stress may increase vulnerability to infectious disease; however, the role of stress in the course of inflammatory bowel disease remains unclear. Because there are large individual differences in psychological response to stress, it is important to consider the role of cognitive and affective responses to stress. Depression has been associated with functional immune decrements and immune overactivation. Cognitive states such as perceived control, views of the self, and views of the future have been associated with immune parameters and health in some studies. Very few controlled clinical trials have been conducted to determine if psychosocial interventions can impact the immune system and the progression of medical conditions. There is suggestive evidence for the health benefits of relaxation training, cognitive-behavioral stress management, and support groups; but, there is little research on many other psychosocial interventions in widespread use for medical conditions. An evidence-based discussion of this research literature with interested patients may help them make informed decisions regarding adjunctive treatments.","PeriodicalId":79377,"journal":{"name":"Seminars in gastrointestinal disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20938971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal surgery for obesity. 胃肠手术治疗肥胖症。

Seminars in gastrointestinal disease Pub Date : 1998-10-01

R E Brolin

引用次数: 0

Nutritional management of anorexia. 厌食症的营养管理。

Seminars in gastrointestinal disease Pub Date : 1998-10-01

K N Jeejeebhoy

引用次数: 0

Nutritional management of patients with feeding-induced pain: acute pancreatitis. 喂养性疼痛患者的营养管理:急性胰腺炎。

Seminars in gastrointestinal disease Pub Date : 1998-10-01

D L Seidner, J A Fish