Radiatsionnaia biologiia, radioecologiia最新文献_第8页

[Radioprotective Properties of NO-synthase Inhibitor T1023: II. The Ability for Selective Protection of Normal Tissues During Radiotherapy of Tumors]. no -合成酶抑制剂T1023的辐射防护性能[j]。肿瘤放疗中正常组织的选择性保护能力[j]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

M V Filimonova, S E Ulyanenko, L I Shevchenko, M N Kuznetsova, V M Makarchuk, E A Chesnakova, A S Samsonova, A S Filimonov

{"title":"[Radioprotective Properties of NO-synthase Inhibitor T1023: II. The Ability for Selective Protection of Normal Tissues During Radiotherapy of Tumors].","authors":"M V Filimonova, S E Ulyanenko, L I Shevchenko, M N Kuznetsova, V M Makarchuk, E A Chesnakova, A S Samsonova, A S Filimonov","doi":"","DOIUrl":"","url":null,"abstract":"We studied the effect of T1023, NO-synthase inhibitor, N-acyl-S-alkyl-isothiourea in a single administration at a dose of 75 mg/kg on the growth of transplantable rat sarcoma M-1 and the development of acute skin reactions after the local impact of γ-radiation at the doses of 32 and 36 Gy. The results showed that the T1023 at a single dose had no effect on the growth of sarcoma, and did not modify the radiosensitivity of the tumor and anti-tumor efficacy of γ-rays. However, at both doses T1023 significantly reduced the severity of acute radiation skin reactions. NOS inhibitor did not change the duration of the inflammatory and regenerative processes, but significantly limited the degree of radiation alteration of the deep layers of the skin and underlying tissues. The findings suggest that the hypoxic mechanism of antitumor action allows T1023 to selectively protect the non-malignant tissue during radiation therapy of solid tumors. Therefore, this compound may be regarded as a promising basis for the development of pharmacological prevention of radiotherapy complications.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"55 3","pages":"260-6"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33953262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The XLIII Radiological Readings Named after V.M. Klechkovsky]. [以V.M. Klechkovsky命名的XLIII放射性读数]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

T I Shilovich

引用次数: 0

[Evaluation of Reproductive Health of Chickens and Their Progeny at a Chronic Effect of 131I]. [131 - i慢性影响下鸡及其后代生殖健康评价]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

V A Boudarkov

引用次数: 0

[Radioprotective Properties of NO-Synthase Inhibitor T1023: I. Indicators of Radioprotective Activity and Interaction with Other Radioprotectors]. no -合成酶抑制剂T1023的辐射防护性能:I.辐射防护活性指标及其与其他辐射防护剂的相互作用

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

M V Filimonova, L I Shevchenko, V M Makarchuk, E A Chesnakova, O S Izmest'eva, T S Korneeva, A S Filimonov

{"title":"[Radioprotective Properties of NO-Synthase Inhibitor T1023: I. Indicators of Radioprotective Activity and Interaction with Other Radioprotectors].","authors":"M V Filimonova, L I Shevchenko, V M Makarchuk, E A Chesnakova, O S Izmest'eva, T S Korneeva, A S Filimonov","doi":"","DOIUrl":"","url":null,"abstract":"The study of radioprotective activity of NO-synthase inhibitor, N-S-isothiourea derivative T1023 showed that this compound has a significant therapeutic range of radioprotective activity (5.5-6.0) and its optimal radioprotective dose is 1/4 LD16. The value of its Radiation Dose-Reduction Factor totaled 1.4-1.8. We have demonstrated a pronounced pharmacodynamic interaction of T1023 with some known radioprotectors. The character of the interaction was determined by its vasoactive properties. Combined use of T1023 and cystamine, which causes a decrease in vascular tone, was accompanied by a statistically significant weakening of the radioprotective effect. But, the combined use of T1023 with serotonergic and adrenergic radioprotectors having a pressor action caused a statistically significant increase in the radioprotective effect. Moreover, T1023 combined with such radioprotectors caused the synergistic radioprotective effect even when used at small doses that do not have any radioprotective effect alone. The findings suggest that NOS inhibitors can be effective radioprotectors and are able to create new opportunities for the development of safer radioprotective agents. The very same compound T1023, according to current criteria of pharmacological screening, is certainly promising for further investigations.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"55 3","pages":"250-9"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33953261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Composition and Density of Soil Fauna in the Region with Enhanced Radioactivity Level (Komi Republic, Vodnyi)]. [放射性水平增强地区(科米共和国，沃德尼)土壤动物组成和密度]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

A A Kolesnikova, A A Kudrin, T N Konakova, A A Taskaeva

引用次数: 0

[Main Results of Scientific Research in the Field of Radiation Biology and Radiation Ecology in 2014]. [2014年辐射生物学与辐射生态学领域主要科研成果]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

V I Naidich

引用次数: 0

[Dynamics of Radioecological State of the Fresh-Water Ecosystems Affected by a Long-Term Impact from Nuclear Power Plant in the Frontiers of the Zone under Observation]. [观察区边界受核电站长期影响的淡水生态系统放射生态学动态]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

A V Trapeznikov, V N Trapeznikova, A V Korjavin

{"title":"[Dynamics of Radioecological State of the Fresh-Water Ecosystems Affected by a Long-Term Impact from Nuclear Power Plant in the Frontiers of the Zone under Observation].","authors":"A V Trapeznikov, V N Trapeznikova, A V Korjavin","doi":"","DOIUrl":"","url":null,"abstract":"The results of radioecological studies of six small rivers situated in the surveillance zone of the Beloyarskaya NPP (BNPP) and around the cooling pond of the power plant are presented. 21 radionuclides and the total α- and β-activity were studied in the main components of the aquatic ecosystems. It is shown that after the 1st and 2nd BN PP blocks decommissioning the content of 60Co and 137Cs in the Beloyarskoye storage pond water, sediments, fish fauna and macrophytes dropped tens and hundreds of times. The fundamental importance of this fact is that in a large range of time the aquatic ecosystem mechanism of self-purification from radionuclides is working due to radioactive substances decay as well as redistribution of radionuclides from water to other components, primarily to the sediments. Of 6 small rivers the maximum levels of radioactive substances is found in the river Olkhovka, which for several years has been subjected to the low-level radioactive water discharges from Beloyarskaya NPP. The radionuclide content in the main components of the aquatic ecosystems of the other five rivers studied after BNPP 47-year operation period corresponds to the regional background.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"55 3","pages":"302-13"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33954279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[On the Birthday Anniversary of Victor Georgievich Vladimirov]. [在维克多·格奥尔基耶维奇·弗拉基米罗夫诞辰纪念日]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

引用次数: 0

[S.I. Auerbach--an Outstanding Scientist and Organizer of Radioecological Research (on the 10th Anniversary of Death) (1922-2004)]. [S.I.奥尔巴赫——杰出的科学家和放射生态学研究的组织者(逝世十周年纪念)(1922-2004)]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-05-01

R M Alexakhin

引用次数: 0

[Migration in soil and accumulation in plants of peaceful nuclear explosion products in Perm region]. [彼尔姆地区和平核爆炸产物在土壤中的迁移和在植物中的积累]。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2015-01-01

N G Raskosha, I I Shuktova

引用次数: 0