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Repeating hemorrhage with a long duration after radiotherapy for glioma: radiological and histological observations. 胶质瘤放射治疗后长时间反复出血:影像学和组织学观察。
Noshuyo byori = Brain tumor pathology Pub Date : 1996-04-01
H Kawano, K Sato, K Hosotani, T Kubota, T Goya, S Arikawa, S Wakisaka
{"title":"Repeating hemorrhage with a long duration after radiotherapy for glioma: radiological and histological observations.","authors":"H Kawano,&nbsp;K Sato,&nbsp;K Hosotani,&nbsp;T Kubota,&nbsp;T Goya,&nbsp;S Arikawa,&nbsp;S Wakisaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of radiation necrosis which was observed 6 years after radiotherapy for a glioma in the right parietal lobe is reported. This patient developed hemiparesis, and radiological examinations showed similar findings consisted with recurrent glioma. Histological examination disclosed the lesion to be radiation necrosis. Repeated episodes of hemorrhage and cystic formation in the right hemisphere appeared during 8 to 10 years after radiotherapy, and removal of the mass lesion conducted four times. Histological examinations of each specimen showed the increasing proliferation of neo-vessels accompanied by hemorrhage and cystic formation.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19881682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes of intermediate filaments in cultured human glioma cells with various growth factors and cytokines using high voltage immunoelectron microscopy. 用高压免疫电镜观察不同生长因子和细胞因子对胶质瘤细胞中间纤维的影响。
Noshuyo byori = Brain tumor pathology Pub Date : 1996-04-01
K Taomoto, A Ijichi, T Arii, K Hama
{"title":"Changes of intermediate filaments in cultured human glioma cells with various growth factors and cytokines using high voltage immunoelectron microscopy.","authors":"K Taomoto,&nbsp;A Ijichi,&nbsp;T Arii,&nbsp;K Hama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Morphological and immunocytological changes of intermediate filaments of cultured human malignant glioma cells were studied by adding various growth factors or cytokines using stereoscopic high voltage electron microscopy operated at 1,000 kV. The gold-colloid immuno-cytochemical method was used to stain GFAP and vimentin. Growth rate of tumor cells increased when EGF, TGF-alpha, and PDGF administered and decreased when FGF, TNF, and CLN-IgG administered. Morphological changes of cells were not remarkable when EGF, PDGF, IL-1, and FGF were administered. The cytoplalsmic organellaes were damaged after administrating TNF and CLN-IgG to cells.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19879977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of histopathological factor of brain tumor and high thallium-201 uptake in single photon emission computed tomography. 脑肿瘤组织病理因素与单光子发射计算机断层高铊-201摄取的相关性。
Noshuyo byori = Brain tumor pathology Pub Date : 1996-04-01
Y Yoshii, T Moritake, T Yamamoto, S Takano, K Tsuboi, A Hyodo, T Nose, M Satou
{"title":"Correlation of histopathological factor of brain tumor and high thallium-201 uptake in single photon emission computed tomography.","authors":"Y Yoshii,&nbsp;T Moritake,&nbsp;T Yamamoto,&nbsp;S Takano,&nbsp;K Tsuboi,&nbsp;A Hyodo,&nbsp;T Nose,&nbsp;M Satou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study was undertaken to investigate the relationship between several histological features and the degree of TI-201 uptake in brain tumors. T1-201 SPECT was performed on 52 patients with intracranial lesions. Histological examinations were carried out to determine the gradation of tumor cell density, vascularization, small-cell density, and matrix loosening, and the presence of necrosis, atypia, mitoses, and endothelial proliferation. The histological findings were classified into three categories. While the early uptake of T1-201 depended on the degree of necrosis of glial tumor, the delayed T1-201 uptake was closely related to the degree of necrosis, tumor cell density, and small-cell density, and may thus be of value for estimating the viability and degree of malignancy of glial tumors. In the non-glial tumors, the early and delayed T1-201 uptakes were closely related to all histological parameters, with the increase of necrosis and vascularization in the tumor tissue being particularly closely related to high uptake levels.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19881678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleomorphic xanthoastrocytoma with neurofibromatosis type 1: case report. 多形性黄色星形细胞瘤合并1型神经纤维瘤病1例。
Noshuyo byori = Brain tumor pathology Pub Date : 1996-04-01
O Kubo, A Sasahara, Y Tajika, H Kawamura, H Kawabatake, K Takakura
{"title":"Pleomorphic xanthoastrocytoma with neurofibromatosis type 1: case report.","authors":"O Kubo,&nbsp;A Sasahara,&nbsp;Y Tajika,&nbsp;H Kawamura,&nbsp;H Kawabatake,&nbsp;K Takakura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors report a case of pleomorphic xanthoastrocytoma (PXA) with neurofibromatosis type 1 (NF-1). A 21-year-old woman, noted to have had a number of café au lait spots since birth, presented with the chief complaint of headache. Neuroradiological studies revealed a cystic tumor of the left parietal lobe. Surgical treatment was performed. The tumor was located on the surface of the parietal lobe with the formation of cysts. Light, electron microscopic, and immunohistochemical examination showed the characteristics of typical PXA. This is the second reported case of NF-1 associated with PXA.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19881681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumours of the meninges: an overview of new entities. 脑膜肿瘤:新实体的概述。
Noshuyo byori = Brain tumor pathology Pub Date : 1995-03-01
B W Scheithauer
{"title":"Tumours of the meninges: an overview of new entities.","authors":"B W Scheithauer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18796702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical localization of the glucose transporter GLUT1 in choroid plexus papillomas. 脉络丛乳头状瘤中葡萄糖转运蛋白GLUT1的免疫组织化学定位。
Noshuyo byori = Brain tumor pathology Pub Date : 1995-03-01
M Kurosaki, T Hori, K Takata, H Kawakami, H Hirano
{"title":"Immunohistochemical localization of the glucose transporter GLUT1 in choroid plexus papillomas.","authors":"M Kurosaki,&nbsp;T Hori,&nbsp;K Takata,&nbsp;H Kawakami,&nbsp;H Hirano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Normal chroid plexus tissue and five choroid plexus papillomas were examined with antibody specific for the glucose transporter GLUT1, one isoform of facilitated-diffusion glucose transporters, using the avidin-biotin-peroxidase complex (ABC) technique. GLUT1 in normal choroid plexus was localized at the basolateral plasma membrane of almost all epithelial cells. In three of five tumors, GLUT1 immunoreactivity was observed. A positive reaction was demonstrated at the plasma membrane of tumor cells. The number of GLUT1-positive cells was, however, much smaller than that of the normal choroid plexus. Our results suggest that GLUT1 expression in the choroid plexus is restrained during the course of transformation and that choroid plexus papilloma is composed of various differentiation tumor cells.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18796633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunostaining for calcineurin, a Ca2+/calmodulin-regulated protein phosphatase, in the diagnostic tumor pathology. 钙调磷酸酶，一种Ca2+/钙调素调节的蛋白磷酸酶，在肿瘤病理诊断中的免疫染色。
Noshuyo byori = Brain tumor pathology Pub Date : 1995-03-01
S Goto, Y Ushio
{"title":"Immunostaining for calcineurin, a Ca2+/calmodulin-regulated protein phosphatase, in the diagnostic tumor pathology.","authors":"S Goto,&nbsp;Y Ushio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present immunochemical study concerns the distribution of calcineurin (CaN), a Ca2+/calmodulin-regulated protein phosphatase, in the nervous and neuroendocrine systems of mammals, and discloses the CaN-immunostaining results of human neoplasms. CaN immunoreactivity (ir) was present throughout the nervous system with a marked regional variation in strength of the staining intensity. Light microscopic observations showed that CaN-ir was localized in neurons, but was not detected in non-neuronal cells including astrocytes. Ultrastructural study also revealed that CaN-ir was present only in neuronal elements such as somata, dendrites including postsynaptic densities and spines, and nerve terminals. CaN-ir was also detected in neuroendocrine cells of some endocrine tissues including the pineal gland, pituitary gland, adrenal grand, pancreas and thyroid gland. Immunostaining results of 107 surgical specimens of human neoplasms, including 9 cases of peripheral tumors, disclosed that CaN-immunopositive tumor cells were found to be present in the neuronal tumors including neuroblastomas, ganglioglioma, ganglioneuroma, ganglioneuroblastoma, retinoblastomas, medulloblastomas and central neurocytomas. Also, some neuroendocrine tumors, such as pineocytomas, olfactory neuroblastomas and paragangliomas, specifically reacted for anti-CaN antibody. On the basis of these immunochemical findings, we have proposed that CaN can be a marker protein for detection of neuronal and neuroendocrine tumor cells in the diagnostic pathology of human neoplasms.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18796704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clear cell (glycogen-rich) meningioma with special reference to spherical collagen deposits. 透明细胞(富含糖原)脑膜瘤，特别涉及球形胶原沉积。
Noshuyo byori = Brain tumor pathology Pub Date : 1995-03-01
T Kubota, K Sato, M Kabuto, M Hasegawa, R Kitai, T Nakagawa, Y Arai, J Yamashita
{"title":"Clear cell (glycogen-rich) meningioma with special reference to spherical collagen deposits.","authors":"T Kubota,&nbsp;K Sato,&nbsp;M Kabuto,&nbsp;M Hasegawa,&nbsp;R Kitai,&nbsp;T Nakagawa,&nbsp;Y Arai,&nbsp;J Yamashita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A detailed immunohistochemical and electron microscopic study of a case of clear cell (glycogen-rich) meningioma is presented. The neoplasm recurred three times and the patient died of the disease. The specimens obtained at all three operations showed similar basic histologic patterns. The tumor was comprised mainly of a syncytial, sheet-like proliferation of polygonal cells with clear cytoplasm containing abundant glycogen. The immunohistochemical features included epithelial membrane antigen- and vimentin-positive cytoplasm. The ultrastructural examination revealed distinctive meningocytic cells which contained large amounts of glycogen granules. In addition, the presence of numerous blocky, collagen conglomerations were a conspicuous feature of this tumor. The collagen deposits exhibited intensive immunopositivity for types I, III, IV and VI collagen, and their fine structure suggested the production of the extracellular matrix substance from the contiguous meningothelial cells with well developed Golgi complexes and frequent vesicles near the cell membrane. Proliferating cell nuclear antigen cell kinetics study revealed high labeling index of this neoplasm. The findings for this clear cell (glycogen-rich) meningioma may be useful in the differential diagnosis and treatment of this distinctive subtype of meningioma.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18796631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear characterization and G2M ploidy in human brain tumors using semiautomated image analysis. 使用半自动图像分析人脑肿瘤的核特征和G2M倍性。
Noshuyo byori = Brain tumor pathology Pub Date : 1995-03-01
Y Yoshii, A Saito, K Tsuboi, H Tsurushima, Y Komatsu, Y Tomono, A Hyodo, T Nose
{"title":"Nuclear characterization and G2M ploidy in human brain tumors using semiautomated image analysis.","authors":"Y Yoshii,&nbsp;A Saito,&nbsp;K Tsuboi,&nbsp;H Tsurushima,&nbsp;Y Komatsu,&nbsp;Y Tomono,&nbsp;A Hyodo,&nbsp;T Nose","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We used image analysis to study nuclear morphometry and DNA content in relation to time to tumor progression in a series of 88 patients with brain tumors. Clinical follow-up was obtained for 73 patients. The patients with diploid tumors had a longer time to tumor progression than those with triploid, tetraploid, or hypertetraploid tumors. Mean SG2M-DNA indices (DIs) increased significantly with a increase in mean DIs in all tumors. The mean DIs appeared to be dependent on the number of SG2M phase cells. We conclude that tumors with hypertetraploid in G2M ploidy are highly malignant. Those tumor cells have a large nuclear size, much deformity in nuclear shape, and great proliferative potential. The G2M-tetraploid tumors showed a shorter time to tumor progression when the number of SG2M fractions was large. In contrast, the G2M-hypotetraploid tumors showed a longer time to tumor progression in comparison with other tetraploid and hypertetraploid tumors, but the difference was not significant.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18796632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological study on the effect of octreotide. 奥曲肽作用的组织病理学研究。
Noshuyo byori = Brain tumor pathology Pub Date : 1995-03-01
S Yokoyama, M Goto, T Asakura, K Hirahara, S Tsuyama, F Murata
{"title":"Histopathological study on the effect of octreotide.","authors":"S Yokoyama,&nbsp;M Goto,&nbsp;T Asakura,&nbsp;K Hirahara,&nbsp;S Tsuyama,&nbsp;F Murata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present investigation was performed to clarify the mechanism of action of octreotide. On a quantitative study by electron microscopy showed that lysosomes were markedly increased in the patients receiving octreotide. Growth hormone (GH) was shown to be in the secretory granules by the postembedding immunogold technique, but no GH immunostaining was noted of the lysosomes. The present investigation suggests that retention of secretory granules and subsequent lysosomal increase are the mechanism of GH-lowering effect of octreotide.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18796634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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