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Clinical significance and immunological basis of candidal infections in immunodeficiency disorders. 免疫缺陷疾病念珠菌感染的临床意义及免疫学基础。
Immunodeficiency Pub Date : 1993-01-01
L Maródi
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引用次数: 0
Human immunoglobulin germline alpha(IgA) transcripts are expressed in vivo and their level correlates to class switching. 人免疫球蛋白种系α (IgA)转录本在体内表达，其水平与类转换相关。
Immunodeficiency Pub Date : 1993-01-01
C I Smith, B Baskin, B Christensson, P Sideras, L Hammarström, K B Islam
{"title":"Human immunoglobulin germline alpha(IgA) transcripts are expressed in vivo and their level correlates to class switching.","authors":"C I Smith,&nbsp;B Baskin,&nbsp;B Christensson,&nbsp;P Sideras,&nbsp;L Hammarström,&nbsp;K B Islam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunoglobulin isotype switching is preceded by transcription of exons located 5' of the immunoglobulin switch regions. These exons are referred to as 'I-exons' and transcription of these regions is believed to be an essential step in switch recombination. Such mRNA species lack a variable portion and are denoted 'germline' transcripts. We have previously identified I-regions in man and we have now investigated the in vivo expression of human germline transcripts. Germline alpha transcripts (containing an I alpha exon) were expressed in various lymphoid organs, including peripheral blood mononuclear cells. Decreased levels of germline transcripts were found in immunoglobulin deficiency diseases. These findings are compatible with an in vivo role of germline transcription in isotype switching and may contribute to the understanding of mechanisms underlying deficiency diseases.</p>","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
X chromosome inactivation patterns in leucocyte populations of female carriers of Wiskott-Aldrich syndrome with an atypical presentation. 具有非典型表现的Wiskott-Aldrich综合征女性携带者白细胞群体中的X染色体失活模式。
Immunodeficiency Pub Date : 1993-01-01
M de Weers, R G Mensink, M E Kraakman, R K Schuurman, R W Hendriks
{"title":"X chromosome inactivation patterns in leucocyte populations of female carriers of Wiskott-Aldrich syndrome with an atypical presentation.","authors":"M de Weers,&nbsp;R G Mensink,&nbsp;M E Kraakman,&nbsp;R K Schuurman,&nbsp;R W Hendriks","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutations in the human mannose binding protein gene: their frequencies in three distinct populations and relationship to serum levels of the protein. 人类甘露糖结合蛋白基因的突变:在三个不同人群中的频率及其与血清蛋白水平的关系。
Immunodeficiency Pub Date : 1993-01-01
M W Turner, R J Lipscombe, R J Levinsky, Y L Lau, A V Hill, J A Summerfield, M Sumiya
{"title":"Mutations in the human mannose binding protein gene: their frequencies in three distinct populations and relationship to serum levels of the protein.","authors":"M W Turner,&nbsp;R J Lipscombe,&nbsp;R J Levinsky,&nbsp;Y L Lau,&nbsp;A V Hill,&nbsp;J A Summerfield,&nbsp;M Sumiya","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Failure of primary and secondary T cell responses in common variable immunodeficiency. 常见可变免疫缺陷的原发性和继发性T细胞反应失败。
Immunodeficiency Pub Date : 1993-01-01
A Stagg, S C Knight, A D Webster, J Farrant
{"title":"Failure of primary and secondary T cell responses in common variable immunodeficiency.","authors":"A Stagg,&nbsp;S C Knight,&nbsp;A D Webster,&nbsp;J Farrant","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of CD8 cells in HIV infection. CD8细胞在HIV感染中的作用。
Immunodeficiency Pub Date : 1993-01-01
L Buijs, P van der Meide, J L Heeney
{"title":"The role of CD8 cells in HIV infection.","authors":"L Buijs,&nbsp;P van der Meide,&nbsp;J L Heeney","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recently much has been elucidated about the role of CD8 cells in HIV infection. Different mechanisms by which CD8 cells are able to control HIV infection have been observed. These mechanisms may be able to positively influence the duration of the asymptomatic period of HIV infection. The implications of studies on CD8 cells in HIV infected individuals as well as clinical applications of these findings are discussed.</p>","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19160184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helper T cell dysfunctions in a patient with Omenn's syndrome: modulation by IFN-gamma therapy. 辅助T细胞功能障碍的患者与Omenn综合征:调节干扰素γ治疗。
Immunodeficiency Pub Date : 1993-01-01
L Schandené, F Mascart-Lemone, A Ferster, C Gérard, M Lybin, E Sariban, T Velu, M Goldman
{"title":"Helper T cell dysfunctions in a patient with Omenn's syndrome: modulation by IFN-gamma therapy.","authors":"L Schandené,&nbsp;F Mascart-Lemone,&nbsp;A Ferster,&nbsp;C Gérard,&nbsp;M Lybin,&nbsp;E Sariban,&nbsp;T Velu,&nbsp;M Goldman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18907038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential uses of polyethylene glycol conjugated recombinant IL-2 in common variable immunodeficiency. 聚乙二醇偶联重组IL-2在常见变异性免疫缺陷中的潜在应用。
Immunodeficiency Pub Date : 1993-01-01
C Cunningham-Rundles, K Kasbay, L Mayer
{"title":"Potential uses of polyethylene glycol conjugated recombinant IL-2 in common variable immunodeficiency.","authors":"C Cunningham-Rundles,&nbsp;K Kasbay,&nbsp;L Mayer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carrier detection in X-linked immunodeficiencies. II: An X inactivation assay based on differential methylation of a line-1 repeat at the DXS255 locus. x连锁免疫缺陷的携带者检测。II:基于DXS255位点1行重复序列差异甲基化的X失活试验。
Immunodeficiency Pub Date : 1993-01-01
H Hinds, I W Craig, Z Y Chen, M E Kraakman, R K Schuurman, R W Hendriks
{"title":"Carrier detection in X-linked immunodeficiencies. II: An X inactivation assay based on differential methylation of a line-1 repeat at the DXS255 locus.","authors":"H Hinds,&nbsp;I W Craig,&nbsp;Z Y Chen,&nbsp;M E Kraakman,&nbsp;R K Schuurman,&nbsp;R W Hendriks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The differential methylation of a CpG island 2.5 kb distant from a hypervariable region at the DXS255 locus provides the basis for a Southern blotting X chromosome inactivation analysis system. The technique enables carrier detection in about 90% of females at risk from pedigrees with Wiskott-Aldrich syndrome, X-linked severe combined immunodeficiency or X-linked agammaglobulinemia.</p>","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additional polymorphisms useful in linkage analysis for X-linked agammaglobulinemia. 在x连锁无球蛋白血症连锁分析中有用的额外多态性。
Immunodeficiency Pub Date : 1993-01-01
O Parolini, M E Conley
{"title":"Additional polymorphisms useful in linkage analysis for X-linked agammaglobulinemia.","authors":"O Parolini,&nbsp;M E Conley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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