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Reviews in pure & applied pharmacological sciences最新文献

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The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism. 必需脂肪酸代谢对前列腺素生物合成的调控。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-10-01
D F Horrobin
{"title":"The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism.","authors":"D F Horrobin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two of the most widely used groups of drugs in medical practice are the non-steroidal anti-inflammatory agents and the steroids. Both act by modulating the conversion of essential fatty acids to prostaglandins, leukotrienes and related substances. The actions of these drugs are therefore likely to be modified by variations in the levels of substrates, notably arachidonic acid and dihomogammalinolenic acid, available for metabolism by lipoxygenase and cyclo-oxygenase enzymes. Yet most doctors who use the drugs and many scientists who carry out research on them seem unaware of the factors which determine the concentrations of the substrate essential fatty acids. This paper reviews in detail the metabolism of essential fatty acids and the interactions between nutrient intake and subsequent metabolism which determine the concentrations of the individual fatty acids. It is concluded that the efficacy of drug therapy as far as the steroids and the non-steroidal anti-inflammatory drugs are concerned could be substantially enhanced by greater knowledge of the factors which determine the availability of substrates to the key enzymes.</p>","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17460547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ontogeny of mammalian neurotransmitter receptors. 哺乳动物神经递质受体的个体发生。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-10-01
R L Braun, M A Peters
{"title":"The ontogeny of mammalian neurotransmitter receptors.","authors":"R L Braun,&nbsp;M A Peters","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17218777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct binding assays in determining psychotropic drug mechanism of action. 测定精神药物作用机制的直接结合试验。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-07-01
P M Whitaker, S J Kish, B K Madras
{"title":"Direct binding assays in determining psychotropic drug mechanism of action.","authors":"P M Whitaker,&nbsp;S J Kish,&nbsp;B K Madras","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17460546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excitotoxic amino acids as tools in neurobiology. 兴奋性毒性氨基酸作为神经生物学的工具。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-07-01
P L McGeer, E G McGeer
{"title":"Excitotoxic amino acids as tools in neurobiology.","authors":"P L McGeer,&nbsp;E G McGeer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17460545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central molecular aspects of tricyclic antidepressant drug action. 三环抗抑郁药物作用的中心分子方面。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-04-01
J Korf
{"title":"Central molecular aspects of tricyclic antidepressant drug action.","authors":"J Korf","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17209232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyrotropin releasing hormone (TRH): possible physiological functions not related to the neuroendocrine system. 促甲状腺激素释放激素(TRH):可能与神经内分泌系统无关的生理功能。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-04-01
A Horita, P W Kalivas, S M Simasko
{"title":"Thyrotropin releasing hormone (TRH): possible physiological functions not related to the neuroendocrine system.","authors":"A Horita,&nbsp;P W Kalivas,&nbsp;S M Simasko","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17209233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacology of excitation-contraction coupling in skeletal muscle. 骨骼肌兴奋-收缩耦合的药理学研究。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-01-01
N Lakshminarayanaiah, C P Bianchi
{"title":"Pharmacology of excitation-contraction coupling in skeletal muscle.","authors":"N Lakshminarayanaiah,&nbsp;C P Bianchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17427405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug related problems in the blood bank. 血库中的药物相关问题。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-01-01
R Sharon, G Kidroni
{"title":"Drug related problems in the blood bank.","authors":"R Sharon,&nbsp;G Kidroni","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17427404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
REM sleep deprivation and dopamine in the CNS. 快速眼动睡眠剥夺和中枢神经系统中的多巴胺。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-01-01
E A Carlini
{"title":"REM sleep deprivation and dopamine in the CNS.","authors":"E A Carlini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17209228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synaptosomes as a tool in the development of new neuroactive drugs. 突触体作为开发新的神经活性药物的工具。
Reviews in pure & applied pharmacological sciences Pub Date : 1983-01-01
M Raiteri
{"title":"Synaptosomes as a tool in the development of new neuroactive drugs.","authors":"M Raiteri","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79251,"journal":{"name":"Reviews in pure & applied pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17209229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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