Placenta. Supplement最新文献_第2页

HLA and the generation of diversity in human pregnancy. HLA与人类妊娠多样性的产生。

Placenta. Supplement Pub Date : 1982-01-01

J A McIntyre, W P Faulk

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Binding of antigen-antibody complexes to mononuclear phagocytes in chorionic villi of human placentae. 人胎盘绒毛膜绒毛中抗原抗体复合物与单核吞噬细胞的结合。

Placenta. Supplement Pub Date : 1981-01-01

G W Wood, C R King

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Solubilization of opiate receptors from human placenta. 人胎盘中阿片受体的增溶作用。

Placenta. Supplement Pub Date : 1981-01-01

M S Ahmed, W L Byrne, W A Klee

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Placental morphometric studies in diabetic pregnancies. 糖尿病妊娠胎盘形态计量学研究。

Placenta. Supplement Pub Date : 1981-01-01

D B Singer, C T Liu, J A Widness, R A Ellis

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Pathology of gestational choriocarcinoma induced in patas monkeys by ethylnitrosourea given during pregnancy. 妊娠期给药乙基亚硝基脲诱发斑猴妊娠期绒毛膜癌的病理研究。

Placenta. Supplement Pub Date : 1981-01-01

J M Rice, G M Williams, A E Palmer, W T London, D L Sly

{"title":"Pathology of gestational choriocarcinoma induced in patas monkeys by ethylnitrosourea given during pregnancy.","authors":"J M Rice, G M Williams, A E Palmer, W T London, D L Sly","doi":"","DOIUrl":"","url":null,"abstract":"A rapidly fatal neoplastic disease with histological and clinical features resembling gestational choriocarcinoma in humans has been observed in patas monkeys. Timed pregnant females were given ethylnitrosourea (ENU) intravenously at doses of 0.1 to 0.4 mmol/kg body weight, beginning on day 30 of gestation and continuing weekly for a total of 12 injections. Of 59 monkeys given ENU during pregnancy, four of 12 subjected to the highest dose and three of the remaining 47 given lower doses died of choriocarcinoma within six months of cessation of ENU exposure. Death was usually caused by exsanguinating haemorrhage. At necropsy, tumour deposits were always numerous in the lungs and were frequently observed in abdominal viscera. An obvious primary uterine tumour was never found, and only one small primary was detected grossly. Sub-endometrial masses of tumour cells were generally observed microscopically, invading the endometrial stroma and forming endovascular tumour deposits in the veins. Both uterine and extrauterine tumour deposits were highly haemorrhagic, often partially necrotic, and consisted of cytotrophoblast-like cells with frequent mitoses, a high degree of cellular pleomorphism and variable but often prominent cytoplasmic glycogen. This tumour was never seen in males or non-gravid adult females. Chorionic gonadotrophin assays conventionally used for human and macaque samples were negative in both normally pregnant and tumour-bearing patas, and did not contribute to the diagnosis. Trophoblast of patas monkeys appears highly susceptible to the carcinogenic effects of ENU and provides an animal model for gestational choriocarcinoma.","PeriodicalId":79246,"journal":{"name":"Placenta. Supplement","volume":"3 ","pages":"223-30"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18013879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental function: toxicology and pathology. 胎盘功能:毒理学和病理学。

Placenta. Supplement Pub Date : 1981-01-01

M Panigel

引用次数: 0

Human chorionic gonadotrophin (HCG) and free alpha subunit secreted by cultured human choriocarcinoma (JEG-3) cells. 培养的人绒毛膜癌细胞分泌的人绒毛膜促性腺激素(HCG)和游离α亚基。

Placenta. Supplement Pub Date : 1981-01-01

R Benveniste, A Scommegna

引用次数: 0

Characterization of the transferrin-binding protein in a human trophoblast. 人滋养细胞中转铁蛋白结合蛋白的表征。

Placenta. Supplement Pub Date : 1981-01-01

C A Enns, H H Sussman

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The beta-adrenergic receptor in human placenta: receptor subtype analysis (beta 1 and beta 2) and partial characterization of the solubilized receptor. 人胎盘中β -肾上腺素能受体:受体亚型分析(β 1和β 2)和溶解受体的部分表征。

Placenta. Supplement Pub Date : 1981-01-01

J J Moore, J A Whitsett

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Cadmium: placental mechanisms of fetal toxicity. 镉:胎儿毒性的胎盘机制。

Placenta. Supplement Pub Date : 1981-01-01

A A Levin, J R Plautz, P A di Sant'Agnese, R K Miller

{"title":"Cadmium: placental mechanisms of fetal toxicity.","authors":"A A Levin, J R Plautz, P A di Sant'Agnese, R K Miller","doi":"","DOIUrl":"","url":null,"abstract":"Subcutaneous injections of 40 mumol/kg of CdCl2 given to rats on day 18 of pregnancy produced a high incidence of fetal death and placental necrosis. Fetuses directly injected with CdCl2 in utero were resistant to cadmium levels far in excess of fetal levels associated with fetal death following maternal injection. Thus cadmium-induced fetal death was not the result of a direct effect of cadmium on the fetus. Similarly, exposure of fetuses or dams to Cd-metallothionein did not produce fetal death. Placental histological changes and high placental accumulations of cadmium suggested placental mechanisms for the toxicity. Histological changes were observed as early as 12 hours after injection and were characteristic of local circulatory responses. Blood flow measurements with radiolabelled microspheres indicated that uteroplacental blood flow was decreased 40 per cent and 75 per cent at 12-16 hours and 18-24 hours after injection. Studies on the initial responses of the placenta to cadmium exposure revealed that biochemical and ultrastructural changes could be observed in the placenta prior to alterations in blood flow and fetal death. No ultrastructural changes were observed in the uterine vascular endothelium. Thus cadmium-induced fetal death was not the result of direct effects of cadmium but may be the result of a placental effect of the heavy metal. A proposed mechanism for the induction of fetal death is that high placental accumulations of cadmium result in trophoblastic damage which leads to a local circulatory response to the injured tissues and a decrease in uteroplacental blood flow. It is the decrease in nutrient and oxygen transport to the fetus that results from trophoblastic damage and blood flow alterations that ultimately induce fetal death.","PeriodicalId":79246,"journal":{"name":"Placenta. Supplement","volume":"3 ","pages":"303-18"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18013656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0