Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography最新文献

{"title":"Stress shielding of the proximal humerus in stemless anatomic total shoulder arthroplasty.","authors":"Iain A Rankin, Joaquim Goffin, L A Kash Khan, David Cairns, Scott L Barker, Kapil Kumar","doi":"10.1177/17585732231168391","DOIUrl":"10.1177/17585732231168391","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the radiographic proximal humerus bony adaptations to stress shielding and associated clinical outcomes following stemless total shoulder arthroplasty.</p><p><strong>Methods: </strong>A retrospective review of all patients who underwent stemless total shoulder arthroplasty surgery at our centre from 2010 to 2020 was performed.</p><p><strong>Results: </strong>In total, 115 stemless total shoulder arthroplasty utilising a single implant design with a minimum one-year follow-up were identified over a 10-year period. The median follow-up was 3.5 years (range: 1-8.9 years). Evidence of stress shielding was observed in 20 cases (17%), (9 mild (8%), 0 moderate (0%), 11 severe (9%). No significant differences were seen between stress shielding and gender, body mass index, post-operative range-of-motion, patient satisfaction, or Oxford shoulder score. No significant differences were seen between the operative technique and stress shielding. No cases had evidence of humeral lucency. In total, 24 cases (21%) had evidence of glenoid lucency of Lazarus grade 0-3. No cases had Lazarus grades 4 or 5. There was no association between stress shielding and humeral lucency, glenoid lucency, or revision procedure.</p><p><strong>Discussion: </strong>Stress shielding in this study occurred at lower rates than anticipated following stemless total shoulder arthroplasty and was not associated with radiographic evidence of lucency, revision procedures, or adverse effect on clinical outcome measures.</p>","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"64 1","pages":"493-500"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84006638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bone Turnover Markers Such as Osteoprotegerin, Sclerostin and Dickkopf-1 in Subclinical Hyperthyroidism.","authors":"Ayşe Elverdi Özbek, Hüseyin Korkmaz, Mehmet Sözen, Süleyman Hilmi İpekçi, Sedat Abuşoğlu, Cem Onur Kıraç, Ali Ünlü, Levent Kebapçılar","doi":"10.1007/s12291-022-01080-6","DOIUrl":"10.1007/s12291-022-01080-6","url":null,"abstract":"<p><p>In this study, it was aimed to assess effects of subclinical hyperthyroidism (SH) on bone metabolism using osteoprotegerin (OPG), sclerostin, Dickkopf-1 (DKK1) and biochemical parameters. This cross-sectional prospective study included 40 patients with SH and 40 euthyroid controls. Serum OPG, sclerostin, DKK-1, type-1 procollagen, C-terminal polypeptide (CTx) and 24-hours urine N-terminal telopeptide (NTx) were measures using ELISA kit. Bone mineral density measurements were performed using dual energy X-ray absorptiometry (DEXA). Risk for 10-years hip and major fracture was estimated by Turkish version of FRAX. No significant difference was detected in age, gender, body mass index, smoking and menopause rates between SH and control groups. The risk for 10-years hip fracture and major osteoporotic fracture were estimated as 4.45% and 0.55% in SH group, respectively. The OPG levels were significantly lower in patients with SH than controls (<i>P</i> = 0.017). No significant difference was detected in other bone formation and degradation parameters. No significant correlation was detected between OPG level and risk for major osteoporotic fracture (<i>P</i> > 0.05); however, a negative correlation was detected between OPG level and risk for hip fracture (rho = 0.233; <i>P</i> = 0.038). Serum OPG is markedly affected in patients with SH. In addition, OPG seemed to be associated with osteoporotic fracture risk. Available data show that SH is significantly associated with risk for fracture; thus, it is important to assess risk for fracture in patients with SH.</p>","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"61 1","pages":"130-135"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83976769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel serum protein biomarkers in the context of 3P medicine for intravenous leiomyomatosis: a data-independent acquisition mass spectrometry-based proteomics study.","authors":"Zhitong Ge, Penghui Feng, Zijuan Zhang, Zhiyong Liang, Rong Chen, Jianchu Li","doi":"10.1007/s13167-023-00338-0","DOIUrl":"10.1007/s13167-023-00338-0","url":null,"abstract":"<p><strong>Background: </strong>Intravenous leiomyomatosis (IVL) is a rare endocrine-associated tumor with unique characteristics of intravascular invasion. This study aimed to identify reliable biomarkers to supervise the development or recurrence of IVL in the context of predictive, preventive, and personalized medicine (PPPM/3PM).</p><p><strong>Methods: </strong>A total of 60 cases were recruited to detect differentially expressed proteins (DEPs) in serum samples from IVL patients. These cases included those with recurrent IVL, non-recurrent IVL, uterine myoma, and healthy individuals without uterine myoma, with 15 cases in each category. Then, weighted gene co-expression network analysis (WGCNA), lasso-penalized Cox regression analysis (Lasso), trend clustering, and a generalized linear regression model (GLM) were utilized to screen the hub proteins involved in IVL progression.</p><p><strong>Results: </strong>First, 93 differentially expressed proteins (DEPs) were determined from 2582 recognizable proteins, with 54 proteins augmented in the IVL group, and the remaining proteins declined. These proteins were enriched in the modulation of the immune environment, mainly by activating the function of B cells. After the integrated analyses mentioned above, a model based on four proteins (A0A5C2FUE5, A0A5C2GPQ1, A0A5C2GNC7, and A0A5C2GBR3) was developed to efficiently determine the potential of IVL lesions to progress. Among these featured proteins, our results demonstrated that the risk factor A0A5C2FUE5 was associated with IVL progression (OR = 2.64). Conversely, A0A5C2GPQ1, A0A5C2GNC7, and A0A5C2GBR3 might act in a protective manner and prevent disease development (OR = 0.32, 0.60, 0.53, respectively), which was further supported by the multi-class receiver operator characteristic curve analysis.</p><p><strong>Conclusion: </strong>Four hub proteins were eventually identified based on the integrated bioinformatics analyses. This study potentiates the promising application of these novel biomarkers to predict the prognosis or progression of IVL by a 3PM approach.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13167-023-00338-0.</p>","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"63 1","pages":"613-629"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83999715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Ventricular Dyssynchrony Casts New Light on the Risk Stratification and Prediction of Prognosis in Patients With Pulmonary Hypertension.","authors":"Shiro Adachi, Yoshihisa Nakano, Kenji Furusawa","doi":"10.1253/circj.CJ-22-0145","DOIUrl":"10.1253/circj.CJ-22-0145","url":null,"abstract":"","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"49 1","pages":"945-946"},"PeriodicalIF":3.1,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84079129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure.","authors":"Shaozhen Feng, Eric K Peden, Qunying Guo, Tae Hoon Lee, Qingtian Li, Yuhui Yuan, Changyi Chen, Fengzhang Huang, Jizhong Cheng","doi":"10.1016/j.jbc.2022.101816","DOIUrl":"10.1016/j.jbc.2022.101816","url":null,"abstract":"<p><p>Jumonji domain-containing protein-3 (JMJD3), a histone H3 lysine 27 (H3K27) demethylase, promotes endothelial regeneration, but its function in neointimal hyperplasia (NIH) of arteriovenous fistulas (AVFs) has not been explored. In this study, we examined the contribution of endothelial JMJD3 to NIH of AVFs and the mechanisms underlying JMJD3 expression during kidney failure. We found that endothelial JMJD3 expression was negatively associated with NIH of AVFs in patients with kidney failure. JMJD3 expression in endothelial cells (ECs) was also downregulated in the vasculature of chronic kidney disease (CKD) mice. In addition, specific knockout of endothelial JMJD3 delayed EC regeneration, enhanced endothelial mesenchymal transition, impaired endothelial barrier function as determined by increased Evans blue staining and inflammatory cell infiltration, and accelerated neointima formation in AVFs created by venous end to arterial side anastomosis in CKD mice. Mechanistically, JMJD3 expression was downregulated via binding of transforming growth factor beta 1-mediated Hes family transcription factor Hes1 to its gene promoter. Knockdown of JMJD3 enhanced H3K27 methylation, thereby inhibiting transcriptional activity at promoters of EC markers and reducing migration and proliferation of ECs. Furthermore, knockdown of endothelial JMJD3 decreased endothelial nitric oxide synthase expression and nitric oxide production, leading to the proliferation of vascular smooth muscle cells. In conclusion, we demonstrate that decreased expression of endothelial JMJD3 impairs EC regeneration and function and accelerates neointima formation in AVFs. We propose increasing the expression of endothelial JMJD3 could represent a new strategy for preventing endothelial dysfunction, attenuating NIH, and improving AVF patency in patients with kidney disease.</p>","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"28 1","pages":"101816"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83989774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in alcohol and cannabis use amongst substance use disorder patients with and without comorbid attention-deficit/hyperactivity disorder.","authors":"Corné Coetzee, Ilse Truter, Anneke Meyer","doi":"10.4102/sajpsychiatry.v28i0.1786","DOIUrl":"10.4102/sajpsychiatry.v28i0.1786","url":null,"abstract":"<p><strong>Background: </strong>Substance use disorders (SUDs) continue to be a public health problem. Attention-deficit/hyperactivity disorder (ADHD) is seen as a risk factor for SUD. Prevalence of alcohol and cannabis use amongst adults with SUD and comorbid ADHD impacts both disorders cognitively and behaviourally.</p><p><strong>Aim: </strong>Our study aimed to compare alcohol and cannabis use between treatment-seeking SUD patients with ADHD and SUD patients without ADHD symptomatology.</p><p><strong>Setting: </strong>Various rehabilitation centres, including the South African National Council on Alcoholism and Drug Dependence (SANCA) Centres, and Private and Provincial Government Substance Abuse Treatment Centres.</p><p><strong>Methods: </strong>A cross-sectional study of adults on drug rehabilitation was conducted. Data on socio-demographic information and alcohol and cannabis use from 185 post-detox inpatients were collected. Diagnoses were based on DSM-IV criteria. Attention-deficit/hyperactivity disorder diagnosis was confirmed by the Diagnostic-Interview for ADHD in Adults (DIVA 2.0). SUD+ADHD (<i>n</i> = 52) and SUD-ADHD (<i>n</i> = 128) groups were compared on alcohol and cannabis use as a function of gender.</p><p><strong>Results: </strong>No significant differences in the use of alcohol between the SUD+ADHD and SUD-ADHD groups were found. However, the SUD+ADHD group showed increased cannabis consumption. Especially, the SUD+ADHD females showed an earlier age of onset of cannabis use than the SUD-ADHD females and revealed that they use cannabis for a longer period compared with the SUD-ADHD females and SUD+ADHD and SUD-ADHD males.</p><p><strong>Conclusion: </strong>The results revealed the relationship between ADHD and cannabis use, especially amongst females with ADHD and reinforce the need to consider ADHD in cannabis use SUD in clinical interventions.</p>","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"70 1","pages":"1786"},"PeriodicalIF":1.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84130544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Journey into Reciprocal Space: A Crystallographer's Perspective. By A. M. Glazer. Morgan & Claypool, 2017. Paperback, pp. 190. Price USD 55.00. ISBN 9781681746203.","authors":"B. Stöger","doi":"10.1107/s2053273319006983","DOIUrl":"https://doi.org/10.1107/s2053273319006983","url":null,"abstract":"For students of crystallography and solid-state physics, coming to terms with reciprocal space means travelling down a thorny road. In this context, a book titled A Journey into Reciprocal Space: A Crystallographer’s Perspective by A. M. Glazer, published by IOP Publishing in the ‘Concise Physics’ series, could fill a glaring gap. The target audience is solid-state physicists who need a gentle introduction to crystallographic concepts and an overview of the field as seen through the eyes of a crystallographer. The book can be divided into a part on crystallography (Chapters 1–3) and a part on solid-state physics (Chapters 5 and 6), with Chapter 4 (‘Dynamical diffraction’) bridging the two. The book has numerous positive aspects. For example, the author warns of common pitfalls (for example monoclinic meaning 61⁄4 90 ), denounces misconceptions such as ‘lattice structure’ and recounts interesting historical anecdotes such as the ‘photosommateur’. Practical applications (for example the metric tensor, measurement methods, Ewald construction, analysis of the Patterson map) are easy to follow. Sadly, however, the presentation is not as rigorous as one could have expected. The less serious, but not less fastidious, problem is inconsistent typography, which gives a sloppy impression. Lengths, vectors and axes are typeset arbitrarily in bold and italics; differentials of volume integrals are systematically written as dr instead of the correct dr. F is designated an ‘amplitude’ and in the next line used as a complex number. The parts of the book that contain the most errors are the mathematical derivations. Only two of the worst errors (one in each part) shall be mentioned here. The Fourier transform of a lattice is given as","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62133880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of disease-causing mutations in sucrase-isomaltase","authors":"Anna Jewczynko, D. Rose, Nardo Nava","doi":"10.1107/S0108767320098219","DOIUrl":"https://doi.org/10.1107/S0108767320098219","url":null,"abstract":"","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44903035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementing high-resolution structure methods with small-angle X-ray scattering data","authors":"M. Graewert, D. Svergun","doi":"10.1107/S0108767320098712","DOIUrl":"https://doi.org/10.1107/S0108767320098712","url":null,"abstract":"","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49323777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural basis of Neisserial lactoferrin binding protein B function","authors":"R. Yadav, S. Chakravarthy, C. Daczkowski, N. Noinaj","doi":"10.1107/S0108767320098074","DOIUrl":"https://doi.org/10.1107/S0108767320098074","url":null,"abstract":"","PeriodicalId":78988,"journal":{"name":"Acta crystallographica. Section A, Crystal physics, diffraction, theoretical and general crystallography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44772711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}