Zeitschrift fur Anatomie und Entwicklungsgeschichte最新文献

Assessment of body composition and association with clinical outcomes in patients with lung and colorectal cancer. 评估肺癌和结直肠癌患者的身体成分及其与临床结果的关系。

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2021-11-26 eCollection Date: 2021-01-01 DOI: 10.1259/bjro.20210048

Naomi S Sakai, Anisha Bhagwanani, Timothy Jp Bray, Margaret A Hall-Craggs, Stuart Andrew Taylor

{"title":"Assessment of body composition and association with clinical outcomes in patients with lung and colorectal cancer.","authors":"Naomi S Sakai, Anisha Bhagwanani, Timothy Jp Bray, Margaret A Hall-Craggs, Stuart Andrew Taylor","doi":"10.1259/bjro.20210048","DOIUrl":"10.1259/bjro.20210048","url":null,"abstract":"Objectives: To assess body composition in patients with non-small cell lung cancer (NSCLC) and colorectal cancer using whole-body MRI and relate this to clinical outcomes.Methods: 53 patients with NSCLC (28 males, 25 females; mean age 66.9) and 74 patients with colorectal cancer (42 males, 32 females; mean age 62.9) underwent staging whole-body MRI scans, which were post-processed to derive fat mass (FM), fat free mass (FFM) and skeletal muscle (SM) indices and SM fat fraction (FF). These were compared between the two cancer cohorts using two-sided t-tests and the chi-squared test. Measurements of body composition were correlated with outcomes including length of hospital stay, metastatic status and mortality.Results: Patients with NSCLC had significantly lower FFM (p = 0.0071) and SM (p = 0.0084) indices. Mean SM FF was greater in patients with NSCLC (p = 0.0124) and was associated with longer hospital stay (p = 0.035). There was no significant relationship between FM, FFM and SM indices and length of hospital stay, metastatic status or mortality.Conclusions: Patients with NSCLC had lower FFM and SM indices than patients with colorectal cancer and greater SMFF, indicating lower SM mass with fatty infiltration. These findings reflect differences in the phenotype of the two groups and suggest patients with lung cancer are more likely to require additional nutritional support.Advances in knowledge: Body composition differs between NSCLC and colorectal cancer. Patients with NSCLC have both a reduced SM mass and greater SM FF suggesting that they are more nutritionally deplete than patients with colorectal cancer.","PeriodicalId":78849,"journal":{"name":"Zeitschrift fur Anatomie und Entwicklungsgeschichte","volume":"71 1","pages":"20210048"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73377149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPα and canonical Wnt signaling. 组蛋白去甲基化酶KDM4A通过对C/EBPα和典型Wnt信号的表观遗传调控来调节成脂和成骨分化。

IF 8

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2020-06-01 Epub Date: 2019-09-12 DOI: 10.1007/s00018-019-03289-w

Qi Qi, Yi Wang, Xiaochen Wang, Junying Yang, Yan Xie, Jie Zhou, Xiaoxia Li, Baoli Wang

{"title":"Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPα and canonical Wnt signaling.","authors":"Qi Qi, Yi Wang, Xiaochen Wang, Junying Yang, Yan Xie, Jie Zhou, Xiaoxia Li, Baoli Wang","doi":"10.1007/s00018-019-03289-w","DOIUrl":"10.1007/s00018-019-03289-w","url":null,"abstract":"Epigenetic modifications play a central role in cell differentiation and development. In the current study, we have recognized lysine demethylase 4A (KDM4A) as a novel epigenetic regulator of osteoblast and adipocyte differentiation. Kdm4a expression was upregulated during osteogenesis and adipogenesis of primary marrow stromal cells and established stromal ST2 line. Overexpression of wild-type Kdm4a promoted adipogenic differentiation and blocked osteogenic differentiation of the progenitor cells. This effect was largely alleviated when the catalytically dead mutation was made. Conversely, depletion or inactivation of Kdm4a in undifferentiated progenitor cells inhibited the formation of adipocytes and promoted the differentiation of osteoblasts. Mechanism explorations showed that overexpression of Kdm4a upregulated the expression of secreted frizzled-related protein 4 (Sfrp4) and CCAAT/enhancer-binding protein α (C/ebpα). Chromatin immunoprecipitation assay demonstrated that KDM4A directly bound the promoters of Sfrp4 and C/ebpα, removed the histone methylation mark H3K9me3, and reduced DNA methylation levels of CpG in promoter regions of C/ebpα and Sfrp4. Furthermore, overexpression of Kdm4a inactivated canonical Wnt signaling. Moreover, activation of canonical Wnt signaling through silencing of Sfrp4 in ST2 attenuated the inhibition of osteogenic differentiation and the enhancement of adipogenic differentiation by KDM4A. These data have identified KDM4A as a novel regulator of osteoblast and adipocyte differentiation and suggest KDM4A inhibition as a potential therapeutic target for treating metabolic disorders such as osteoporosis.","PeriodicalId":78849,"journal":{"name":"Zeitschrift fur Anatomie und Entwicklungsgeschichte","volume":"110 1","pages":"2407-2421"},"PeriodicalIF":8.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73391701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cataracts and Subclinical Carotid Atherosclerosis in Older Adults　- A Cross-Sectional Study of the HEIJO-KYO Cohort. 老年人的白内障和亚临床颈动脉粥样硬化--HEIJO-KYO 队列的横断面研究。

IF 3.1

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2019-09-25 Epub Date: 2019-07-31 DOI: 10.1253/circj.CJ-19-0118

Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Tomo Nishi, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata

{"title":"Cataracts and Subclinical Carotid Atherosclerosis in Older Adults　- A Cross-Sectional Study of the HEIJO-KYO Cohort.","authors":"Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Tomo Nishi, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata","doi":"10.1253/circj.CJ-19-0118","DOIUrl":"10.1253/circj.CJ-19-0118","url":null,"abstract":"Background: Decreased light reception because of cataracts leads to potential circadian misalignment, resulting in exacerbation of atherosclerosis; however, little is known about the association between cataracts and atherosclerosis in populations.Methods and results: In this cross-sectional study, cataracts were graded using slit lamp biomicroscopy with the Lens Opacities Classification System III and carotid atherosclerosis was assessed based on carotid intima-media thickness (IMT) measured using ultrasonography of the common carotid artery in 442 elderly participants (mean age, 70.0 years). Cataract was defined as nuclear cataract grade ≥3.0, cortical cataract grade ≥2.0, or posterior subcapsular cataract grade ≥2.0 in both eyes. The mean and maximal carotid IMT was 0.86±0.15 mm and 1.07±0.29 mm, respectively. In multivariable analysis adjusted for potential confounders, the mean and maximal carotid IMT were significantly greater in the cataract group than in the non-cataract group by 0.04 mm (95% confidence interval (CI), 0.01-0.06) and 0.07 mm (95% CI, 0.01-0.12), respectively. Logistic regression analysis adjusted for confounders revealed a significantly higher odds ratio for carotid atherosclerosis (maximal carotid IMT ≥1.1 mm) in the cataract group than in the non-cataract group (odds ratio, 1.78; 95% CI, 1.14-2.78).Conclusions: Cataracts may be independently associated with subclinical carotid atherosclerosis in the elderly population, indicating a need for further prospective studies.","PeriodicalId":78849,"journal":{"name":"Zeitschrift fur Anatomie und Entwicklungsgeschichte","volume":"93 1","pages":"2044-2048"},"PeriodicalIF":3.1,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73381251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum zu: Zur Myologie der Erdkröte 祖：蟾蜍的肌肉学

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2014-01-09 DOI: 10.1007/BF02117707

Rudolph Bigalke

引用次数: 1

Robert Bonnet 罗伯特·盖

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2007-01-01 DOI: 10.1007/BF02593570

引用次数: 0

Die antike Beckenlinie am Torso des Jünglings von Subiaco 在苏珊的儿子的守望者

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2007-01-01 DOI: 10.1007/BF02593649

H. Hoepke

引用次数: 0

Das Fettgewebe der Vögel 鸟的脂肪

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2007-01-01 DOI: 10.1007/BF02593697

M. Clara

引用次数: 62

Zur Kenntnis der Trophoblastschale bei jungen menschlichen Eiern 知道人类卵的毛囊

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2007-01-01 DOI: 10.1007/BF02593648

O. Grosser

引用次数: 5

Die Entwicklung des häutigen Labyrinths beim Kiebitz (Vanellus cristatus) 贝兹的皮料迷宫的演化

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2007-01-01 DOI: 10.1007/BF02593696

F. Fuchs

引用次数: 0

Anatomie und Kinematik der Gelenke der Pferdeextremitäten 马四肢器官的解剖和动态性能

Zeitschrift fur Anatomie und Entwicklungsgeschichte Pub Date : 2007-01-01 DOI: 10.1007/BF02593692

A. Stoß

引用次数: 6