Alexandria Journal of Pediatrics最新文献_第2页

Assessment of clinical and epidemiological data of inflammatory bowel disease in Egyptian children attending Mansoura University Children Hospital 曼苏拉大学儿童医院埃及儿童炎症性肠病的临床和流行病学资料评估

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_11_23

Othman AbouBakr, Khalid Elkasaby, Mohammed Ezz El regal, T. Barakat

引用次数: 0

Acute intradialytic blood pressure changes in pediatrics; incidence, risk factors and management: single-center experience 儿科急性血溶内血压变化;发病率、危险因素和管理:单中心经验

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_23_23

Reham Wagdy, MohamedA.E.H Thabet, AdelM Baker, ShaymaaR El Sayed

{"title":"Acute intradialytic blood pressure changes in pediatrics; incidence, risk factors and management: single-center experience","authors":"Reham Wagdy, MohamedA.E.H Thabet, AdelM Baker, ShaymaaR El Sayed","doi":"10.4103/ajop.ajop_23_23","DOIUrl":"https://doi.org/10.4103/ajop.ajop_23_23","url":null,"abstract":"Background Despite Hemodialysis (HD) is a relatively safe procedure for End Stage Kidney Disease (ESKD) patients, Intradialytic (ID) hypotension and hypertension are frequently reported complications in many adults’ studies. However, little is known about acute intradialytic complications in children. Objective This study aimed to assess the incidence of acute ID blood pressure (BP) changes among children attending the HD unit at our institute. Furthermore, it assessed the possible risk factors and the management options. Patients and methods All children with ESKD on chronic HD were enrolled. A checklist was fulfilled every dialysis session over a six-month period, including patient’s demographic data, dialysis session details: frequency/week, duration of session, ultrafiltration volume, BP, vital signs, IVC diameter, dry weight and predialysis weight. All cases were subjected to echocardiography for estimation of cardiac function. Results Thirty-two patients with mean age of 9.16±2.48 years, and who dialyzed a total of 2678 sessions, were included in the current study. ID hypotension was the top (71.8%) of all complications with an incidence rate of 12.6% in all sessions, followed by ID hypertension (25.7%) with an incidence rate of 4.5% in all sessions. ID hypotension was significantly associated with males, with predialytic hypertension (P<0.001), high ultrafiltration rate (P0.033), and longer durations of sessions (mean >3.56 h±0.56 h) (P<0.001). However, less duration (mean < 3.33 h±0.55) and a lower percentage of ID weight loss were independent risk factors for the development of ID hypertension. Conclusion ID blood pressure changes are the most frequent complications in our study; hypotension is on the top of list (12.6% per sessions) followed by hypertension (4.5% per sessions). ID blood pressure is influenced by multiple risk factors; mainly by predialytic hypertension, duration of session and ID weight loss.","PeriodicalId":7866,"journal":{"name":"Alexandria Journal of Pediatrics","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herlyn-Werner-Wunderlich (HWW) syndrome: a case report Herlyn-Werner-Wunderlich综合征1例

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_17_23

Vijayan Sharmila, Shalini Singh, Vandana Kamatham, ThirunavukkarasuArun Babu

引用次数: 0

Clinico-epidemiological aspects of fever of unknown origin in children: tertiary hospital study 儿童不明原因发热的临床流行病学方面:三级医院研究

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_9_23

Wafaa E.M Attia, MyadaS Elhussiny, SamirM AbuElhassan

引用次数: 0

Evaluation of serum levels of interferon beta (INF-B) and Nucleotide-binding oligomerization domain 2 (NOD2) gene polymorphism in children with atopic asthma phenotype 儿童特应性哮喘表型血清干扰素β (INF-B)水平和核苷酸结合寡聚化结构域2 (NOD2)基因多态性的评价

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_25_23

RaniaS Aloraby, MagdyM.E Zedan, NashwaK Abousamra, Yahya Wahba, SuzyA El-Mabood Abd El-Hameed

{"title":"Evaluation of serum levels of interferon beta (INF-B) and Nucleotide-binding oligomerization domain 2 (NOD2) gene polymorphism in children with atopic asthma phenotype","authors":"RaniaS Aloraby, MagdyM.E Zedan, NashwaK Abousamra, Yahya Wahba, SuzyA El-Mabood Abd El-Hameed","doi":"10.4103/ajop.ajop_25_23","DOIUrl":"https://doi.org/10.4103/ajop.ajop_25_23","url":null,"abstract":"Background People of all ages are primarily affected by the chronic inflammatory disease asthma, which is most common in children. A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire found 7.7% of Nile Delta schoolchildren had asthma. This research was to show is their association between the underlying gene polymorphisms of NOD2 and serum level of INF beta and atopic asthma phenotype in Egyptian children and evaluate is their relationship between NOD2 gene polymorphism and the serum level of INF beta. Methods The 127 asthmatic children in this case-control study had typical asthma symptoms, and the 39 age- and sex-matched healthy controls. Subjects were divided in to three groups: Atopic asthma phenotype group: included 60 asthmatic children who had allergic rhinitis and atopic dermatitis as a predominant symptom, Wheezy phenotype group: included 67 asthmatic children presented predominantly with wheezes and controls: 39 healthy controls were chosen because they appeared to be in good health, had no history of symptoms similar to those of asthma, and had no relatives who had allergies or asthma. Results Total serum IgE and eosinophil percentage in control groups showed a positive correlation (r=0.640, P=0.006). In asthmatics, serum INF-β and IgE correlated positively (r=0.217, P=0.031). Increased Serum eosinophilic percentage was associated with decreased serum INF-β and increased serum IgE. Conclusions In comparison to the wheezy phenotype group, the percentage of eosinophils is significantly higher in the atopic asthma phenotype. Serum INF-β and IgE levels went up in tandem with the percentage of eosinophils in the blood. rs2066845 NOD2 genotype The GG genotype increased the risk of asthma in general but not the type of asthma.","PeriodicalId":7866,"journal":{"name":"Alexandria Journal of Pediatrics","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acardiac twinning with sacrococcygeal teratoma–A rare case report and review of literature 心脏双胞胎合并骶尾畸胎瘤1例罕见报告及文献复习

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_16_23

Vijayan Sharmila, Padmapriya Balakrishnan, ThirunavukkarasuA Babu

引用次数: 0

Pituitary and growth disorders of pediatric survivors of head and neck tumors: a single center study 儿童头颈部肿瘤幸存者的垂体和生长障碍:一项单中心研究

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_21_23

Shaymaa Raafat, OmneyaM Omar, Dotto Aron, RehamA Haleem Abo Elwafa, ShadyH Fadel

{"title":"Pituitary and growth disorders of pediatric survivors of head and neck tumors: a single center study","authors":"Shaymaa Raafat, OmneyaM Omar, Dotto Aron, RehamA Haleem Abo Elwafa, ShadyH Fadel","doi":"10.4103/ajop.ajop_21_23","DOIUrl":"https://doi.org/10.4103/ajop.ajop_21_23","url":null,"abstract":"Objective The aim was to explore the prevalence and risk factors for pituitary and growth disorders in pediatric brain and neck tumor survivors. Methods 203 children with brain or neck tumors that survived 2 years after tumors treatment were included. Demographic data, anthropometric assessments, characteristics of the tumors, tumor treatment modalities, and hormonal profile evaluation were reported. Results After a mean follow-up of 4.77 years, 62 (30.54%) survivors were diagnosed with at least one pituitary disorder. Growth hormone deficiency (GHD) was detected in 17.28% of survivors, moreover, thyroid-stimulating hormone deficiency (TSHD), luteinizing hormone and follicle-stimulating hormone deficiency (LH/FSHD), adrenocorticotropic hormone deficiency (ACTHD)/cortisol deficiency and central precocious puberty were detected in 10.4, 9.09, 8.06, and 1.69% of survivors, respectively. The prevalence of short stature and obesity was 9.1% and 17.05%, respectively among survivors who attended follow-up clinics during data collection. The risk of developing pituitary disorders was associated with craniopharyngioma histology (OR, 6.207; 95% CI, 1.025–37.581) and a history of hydrocephalus at cancer diagnosis (OR, 3.075; 95% CI, 1.402–6.746). Older age at the time of radiotherapy was associated with a lower risk of developing pituitary disorders (OR, 0.928; 95% CI, 0.864–0.997). Conclusion This study observed a high prevalence of pituitary disorders among survivors of pediatric brain and neck tumors. So proper screening of pituitary disorders in survivors of brain and neck tumors is warranted.","PeriodicalId":7866,"journal":{"name":"Alexandria Journal of Pediatrics","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal sickle cell disease leading to placental insufficiency and fetal growth restriction: a case report and review of literature 母亲镰状细胞病导致胎盘功能不全和胎儿生长受限:1例报告和文献复习

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_13_23

Thirunavukkarasu Arun Babu, Padmapriya Balakrishnan, Vijayan Sharmila

引用次数: 0

Role of reticulocyte haemoglobin content in diagnosis of iron deficiency anaemia 网织红细胞血红蛋白含量在缺铁性贫血诊断中的作用

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_24_23

AsmaaA.A Abozid, MohamedA Badr, ShaimaaS.A Elashkar, WeaamA Ismail, Dianna Hanna

{"title":"Role of reticulocyte haemoglobin content in diagnosis of iron deficiency anaemia","authors":"AsmaaA.A Abozid, MohamedA Badr, ShaimaaS.A Elashkar, WeaamA Ismail, Dianna Hanna","doi":"10.4103/ajop.ajop_24_23","DOIUrl":"https://doi.org/10.4103/ajop.ajop_24_23","url":null,"abstract":"Background Multiple studies have demonstrated the value of detecting reticulocyte Hb (CHr) in peripheral blood samples for the diagnosis of iron insufficiency. It has been shown to be a reliable iron marker for gauging the efficacy of iron therapy and giving a precise assessment of iron status. Aim of work To improve the management of children with iron deficiency anaemia via evaluation of the significance of CHr in the diagnosis of IDA and comparing CHr with other iron parameters especially transferrin saturation and serum ferritin. Methods The study was a prospective, case-control study. It was conducted at the out-patient hematology clinic, pediatrics department, Zagazig University Hospital during six months from September 2022 to February 2023 after obtaining approval from Institutional Review Board (IRB #:9660-26-7-2022). Consecutive, non-selected 40 patients referred for anemia diagnosis were included in the study in addition to healthy 40 children of matched age and sex attending pediatric clinics for other causes than anemia who served as control group. All patients were subjected to full history taking, routine clinical examination, laboratory investigations including CBC and (CHr), iron parameters including serum iron, serum ferritin, TIBC, Transferrin saturation. Results The best cutoff of reticulocytes hemoglobin in diagnosis of anemia is ≥28.8%, area under curve 0.943, sensitivity 92.5%, specificity 82.5%, positive predictive value 84.1%, negative predictive value 91.7%, overall accuracy 87.5%. There is statistically highly significant difference between the studied groups regarding reticulocyte hemoglobin. Conclusion Our study demonstrates that CHr is a useful parameter that can be confidently used in the diagnosis of IDA. CHr can be a good predictor of IDA as evidenced by the correlations between the CHr and conventional haemtological and biochemical parameters of iron deficiency anemia.","PeriodicalId":7866,"journal":{"name":"Alexandria Journal of Pediatrics","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mature teratoma presenting as presacrococcygeal cystic mass in a neonate: a rare case report 成熟畸胎瘤表现为新生儿肩尾骨前囊性肿块:罕见病例报告

Alexandria Journal of Pediatrics Pub Date : 2023-01-01 DOI: 10.4103/ajop.ajop_5_23

T. Babu, P. Balakrishnan

引用次数: 0