Analytica最新文献_第8页

Deep Learning for Raman Spectroscopy: A Review 拉曼光谱的深度学习研究进展

Analytica Pub Date : 2022-07-19 DOI: 10.3390/analytica3030020

Ruihao Luo, J. Popp, T. Bocklitz

引用次数: 24

Oil Media on Paper: Investigating the Effect of Linseed Oils on Lignocellulosic Paper Supports 纸上的油媒:研究亚麻籽油对木质纤维素纸载体的影响

Analytica Pub Date : 2022-07-02 DOI: 10.3390/analytica3030019

P. Banou, S. Boyatzis, Konstantinos Choulis, Thanasis Karabotsos, Dimitris Tsimogiannis, L. Tsakanika, C. Tzia, A. Alexopoulou

{"title":"Oil Media on Paper: Investigating the Effect of Linseed Oils on Lignocellulosic Paper Supports","authors":"P. Banou, S. Boyatzis, Konstantinos Choulis, Thanasis Karabotsos, Dimitris Tsimogiannis, L. Tsakanika, C. Tzia, A. Alexopoulou","doi":"10.3390/analytica3030019","DOIUrl":"https://doi.org/10.3390/analytica3030019","url":null,"abstract":"Condition assessment of works of art created with oil media on paper could be a complex matter when presenting problems of damage due to the absorption of oil binders by the paper support, since they depend on several factors and occur in variable conditions. The present work refers to the results of an investigation on the effect of linseed oils on the color, opacity, morphology, tensile strength, and chemical properties of lignocellulosic papers, in comparison to that of pure cellulosic papers. Lignocellulosic papers are involved in research on new, yet significant, parameters that might influence the behavior of the oil-impregnated areas of the supports upon aging. The research was applied to mock-ups, made of two types of lignocellulosic paper impregnated with three types of linseed oil and subjected to accelaratated ageing in specific conditions of relative humidity and temperature in closed environment. The research involved colorimetry, opacity, tensile strength, pH measurements, SEM, FTIR, and VOC analysis with GC-MS. The results indicated that thermal-humid ageing caused the gradual darkening of the oil-impregnated mock-ups, alterations in opacity, and decrease of pH values, depending mainly on the formulation of linseed oil, as well as a reduction in tensile strength. FTIR analysis results indicated that the chemical changes that occur upon ageing supported the recorded optical and mechanical alterations, while VOC emissions are both associated with the paper type and the kinetics of degradation of the different types of linseed oil.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90196423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Simple and Reliable Liquid Chromatographic Method for Simultaneous Determination of Five Benzodiazepine Drugs in Human Plasma 一种简便可靠的液相色谱法同时测定人血浆中5种苯二氮卓类药物

Analytica Pub Date : 2022-06-16 DOI: 10.3390/analytica3020018

H. M. Albishri, Naflaa A. Aldawsari, D. Abd El-Hady

{"title":"A Simple and Reliable Liquid Chromatographic Method for Simultaneous Determination of Five Benzodiazepine Drugs in Human Plasma","authors":"H. M. Albishri, Naflaa A. Aldawsari, D. Abd El-Hady","doi":"10.3390/analytica3020018","DOIUrl":"https://doi.org/10.3390/analytica3020018","url":null,"abstract":"Benzodiazepines (BZDs) are one of the most important drugs that have been used in the treatment of neuropsychological disorders. Indeed, BZDs are abused by drug addicts regardless of their therapeutic uses. Therefore, it was important in forensic and clinical toxicology to reach an easy and reliable method for the screening and quantification of BZDs in the human plasma matrix. In the current work, five BZDs, namely bromazepam, clonazepam, lorazepam, nordiazepam and diazepam were simultaneously separated and detected by a simple and reliable RPLC method in a human plasma matrix. Isocratic mobile elution consisting of 20 mmol L−1 phosphate buffer (pH 7.0) and methanol (50:50, v/v) on a Symmetry C18 column was employed. The flow rate, wavelength and column temperature were fixed at 1.0 mL min−1, 214 nm and 40 °C, respectively. The proposed method was validated, giving a linearity within the concentration ranges 5–500 ng mL−1 for bromazepam and diazepam, 3–500 ng mL−1 for clonazepam and lorazepam and 1–500 ng mL−1 for nordiazepam with a determination coefficient (R2) more than 0.9992. The LOD values for the selected BZDs ranged from 0.54 to 2.32 and from 1.78 to 7.65 ng mL−1 for standard methanolic and plasma matrices, respectively. Precision, accuracy, selectivity, stability, and robustness were some of the terms considered in validating the current RPLC method. Based on these results, a simple and reliable RPLC method was successfully applied to quantify BZDs in human plasma matrix appearing with recoveries ranging from 96.5 to 107.5% and interday RSD less than 4%. The current developed method was useful for rapidly screening the most commonly used BZDs in the market within their therapeutic concentration ranges.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"310 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75018204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Ionic Liquids in Capillary Electrophoresis 离子液体在毛细管电泳中的作用

Analytica Pub Date : 2022-06-02 DOI: 10.3390/analytica3020017

I. Ali, M. Suhail, M. Locatelli, Salim Ali, Hassan Y. Aboul-Enein

引用次数: 3

In Vitro Antifungal Antibacterial Activity of Partitions from Euphorbia tirucalli L. 大戟分区体外抗真菌活性的研究。

Analytica Pub Date : 2022-05-23 DOI: 10.3390/analytica3020016

M. S. Heya, M. J. Verde-Star, S. Galindo-Rodríguez, C. Rivas-Morales, E. Robledo-Leal, D. García-Hernández

引用次数: 0

Methodology for Determining Phthalate Residues by Ultrasound–Vortex-Assisted Dispersive Liquid–Liquid Microextraction and GC-IT/MS in Hot Drink Samples by Vending Machines 自动售货机热饮样品中邻苯二甲酸酯残留量的超声-涡辅助分散液-液微萃取和GC-IT/MS测定方法

Analytica Pub Date : 2022-05-05 DOI: 10.3390/analytica3020015

G. Ianiri, Cristina Di Fiore, S. Passarella, Ivan Notardonato, Alessia Iannone, Fabiana Carriera, Virgilio Stillittano, V. De Felice, M. V. Russo, P. Avino

{"title":"Methodology for Determining Phthalate Residues by Ultrasound–Vortex-Assisted Dispersive Liquid–Liquid Microextraction and GC-IT/MS in Hot Drink Samples by Vending Machines","authors":"G. Ianiri, Cristina Di Fiore, S. Passarella, Ivan Notardonato, Alessia Iannone, Fabiana Carriera, Virgilio Stillittano, V. De Felice, M. V. Russo, P. Avino","doi":"10.3390/analytica3020015","DOIUrl":"https://doi.org/10.3390/analytica3020015","url":null,"abstract":"In this study, a simple, fast, and effective methodology has been developed for the detection and quantification of seven phthalates potentially released in hot drinks from disposable containers used in vending machines. The authors determined the optimal conditions to be applied during the various steps of extraction of seven phthalates (DMP, DEP, DBP, DiBP, DEHP, DNOP, and DDP) from hot beverages using a model solution. The extraction and preconcentration technique used was ultrasound–vortex-assisted dispersive liquid–liquid microextraction (UVA-DLLME) followed by gas chromatographic analysis obtaining recoveries from 66.7% to 101.2% with precision and reproducibility <6.3% and <11.1%, respectively. The influence of waiting time, from the dispensing of the drink to its actual consumption, for the extraction of molecules was investigated, obtaining a temporal release profile slightly shifted towards the PAEs with higher molecular weight and vice versa for those with low molecular weight. In addition, the best instrumental parameters to be applied during the analysis of the extracts obtained were established. This optimization was carried out using GC-FID, whereas the analysis of real samples was carried out by means of GC-IT/MS for ultra-trace analysis purposes; limits of detection (LODs) ranging between 0.8 ng mL−1 and 15.4 ng mL−1 and limits of quantification (LOQs) from 1.6 ng mL−1 to 35.8 ng mL−1, both of them lower than those found by FID, were obtained.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74797887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Sweat-Sampling Procedures for Human Stress-Biomarker Detection 人类压力生物标记物检测的汗液取样程序评价

Analytica Pub Date : 2022-04-16 DOI: 10.3390/analytica3020013

M. J. Nunes, José J. G. Moura, J. Noronha, L. C. Branco, A. Samhan-Arias, João P. Sousa, C. Rouco, C. Cordas

{"title":"Evaluation of Sweat-Sampling Procedures for Human Stress-Biomarker Detection","authors":"M. J. Nunes, José J. G. Moura, J. Noronha, L. C. Branco, A. Samhan-Arias, João P. Sousa, C. Rouco, C. Cordas","doi":"10.3390/analytica3020013","DOIUrl":"https://doi.org/10.3390/analytica3020013","url":null,"abstract":"Sweat is a potential biological fluid for the non-invasive analytical assessment of diverse molecules, including biomarkers. Notwithstanding, the sampling methodology is critical, and it must be assessed prior to using sweat for clinical diagnosis. In the current work, the analytical methodology was further developed taking into account the sampling step, in view of the identification and level variations of sweat components that have potential to be stress biomarkers using separation by liquid chromatography and detection by tandem mass spectrometry, in order to attain a screening profile of 26 molecules in just one stage. As such, the molecule identification was used as a test for the evaluation of the sampling procedures, including the location on the body, using patches for long-term sampling and vials for direct sampling, through a qualitative approach. From this evaluation it was possible to conclude that the sampling may be performed on the chest or back skin. Additionally, possible interference was evaluated. The long-term sampling with patches can be used under both rest and exercise conditions with variation of the detected molecule’s levels. The direct sampling, using vials, has the advantage of not having interferences but the disadvantage of only being effective after exercise in order to have enough sample for sweat analysis.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82262875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development and Validation of an HPLC Method for the Determination of Meloxicam and Pantoprazole in a Combined Formulation 高效液相色谱法测定复方美洛昔康和泮托拉唑含量的建立与验证

Analytica Pub Date : 2022-04-01 DOI: 10.3390/analytica3020012

Raneem Ahmad, M. Hailat, Z. Zakaraya, O. Al Meanazel, W. Abu Dayyih

{"title":"Development and Validation of an HPLC Method for the Determination of Meloxicam and Pantoprazole in a Combined Formulation","authors":"Raneem Ahmad, M. Hailat, Z. Zakaraya, O. Al Meanazel, W. Abu Dayyih","doi":"10.3390/analytica3020012","DOIUrl":"https://doi.org/10.3390/analytica3020012","url":null,"abstract":"Nonsteroidal anti-inflammatory drugs are the most commonly prescribed anti-inflammatory drugs worldwide. The most common side effects are gastrointestinal. Pantoprazole, a proton pump inhibitor (PPI), can be used to prevent these events from occurring. In this study, we attempt to develop and validate a novel method for determining and validating the fixed-dose combination of meloxicam and pantoprazole. A new method has been developed and validated to estimate pantoprazole and meloxicam in a fixed-dose combination using RP-HPLC. In order to separate the drugs, a mobile phase phosphate buffer/acetate was used (30:70, v/v), with a pH of 3.4 and a flow rate of 1.0 mL/min at 25 °C. The detection wavelength for the drugs was at a wavelength of 310 nm. The retention times for meloxicam and pantoprazole were 6 and 9 min, respectively. In concentrations ranging from 0.1 to 200 mg/L, the linearity of the detector was established. The r was 0.9998 for both drugs. Recovery rates ranged from 98 to 102% on average. According to the guidelines of the International Council on Harmonization, the results were satisfactory. Using the method presented herein, the pharmaceutical formulation of the combined meloxicam and pantoprazole can be routinely tested.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73241072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Rare Earth Elements Determination by Inductively Coupled Plasma Mass Spectrometry after Alkaline Fusion Preparation 碱性熔合制备后电感耦合等离子体质谱法测定稀土元素

Analytica Pub Date : 2022-03-18 DOI: 10.3390/analytica3010010

H. Mnculwane

{"title":"Rare Earth Elements Determination by Inductively Coupled Plasma Mass Spectrometry after Alkaline Fusion Preparation","authors":"H. Mnculwane","doi":"10.3390/analytica3010010","DOIUrl":"https://doi.org/10.3390/analytica3010010","url":null,"abstract":"There is an increasing worldwide demand for rare earth elements (REEs) in new technological applications—such as electronics, superconductors, space applications, etc. The determination of low concentration REEs in geological samples is extremely important since they are the source materials for all REE products. In order to improve the accuracy and precision of REE measurements by inductively coupled plasma mass spectrometry (ICP-MS); complete digestion of refractory phases and minerals in the samples, low procedural blanks, separation of interfering matrix, and elimination of interference on the mass of the analytes of interest must be fulfilled. Conventional methods that use a hotplate and a mixture of four acids are effective but can take time to achieve complete dissolution of samples that contain highly refractory phases, which is unacceptable in the mining and metallurgical industry. Such difficult samples necessitate high-temperature alkaline flux fusion as it offers a faster and more efficient alternative to acid digestion. This paper presents an accurate, precise, rapid, and reliable method for rare earth element analysis by ICP-MS with low detection limits, which involves no sample pre-concentration, and is therefore able to deliver data rapidly. The analytical performance of the developed method was tested successfully on various REE rock-type certified reference materials and evaluated statistically. The results obtained were in reasonable agreement with published certificate values.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86787301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Investigation of Pazopanib and Human Serum Albumin Interaction Using Spectroscopic and Molecular Docking Approaches 利用光谱和分子对接方法研究帕唑帕尼与人血清白蛋白的相互作用

Analytica Pub Date : 2022-03-18 DOI: 10.3390/analytica3010011

A. Cetinkaya, M. Caglayan, M. A. Unal, Pinar Beyazkilic, Caglar Elbuken, E. B. Atici, S. Ozkan

{"title":"Investigation of Pazopanib and Human Serum Albumin Interaction Using Spectroscopic and Molecular Docking Approaches","authors":"A. Cetinkaya, M. Caglayan, M. A. Unal, Pinar Beyazkilic, Caglar Elbuken, E. B. Atici, S. Ozkan","doi":"10.3390/analytica3010011","DOIUrl":"https://doi.org/10.3390/analytica3010011","url":null,"abstract":"Pazopanib (PAZ), a tyrosine kinase inhibitor, is used to treat advanced renal cell carcinoma (RCC) and advanced soft tissue sarcoma (STS). The FDA approved PAZ for RCC in 2009 and for STS in 2012. The antitumor activity of pazopanib, according to the degree of inhibition, shows different results depending on the dose. Renal cell carcinoma is the most sensitive carcinoma to pazopanib, with 77% inhibition at the 10 mg/kg dose. Clinical studies have shown 53% to 65% inhibition in carcinomas such as breast carcinoma, prostate carcinoma, and melanoma. Plasma proteins such as human serum albumin (HSA) have a critical role in transporting and storing bioactive components. This feature of HSA is very important for the development of cancer therapy. Here, we investigated the interaction between PAZ and HSA to evaluate their binding strength, binding types, and conformational change in HSA. We used spectroscopic methods to assess the drug–protein interaction. Fluorescence measurements revealed that the interaction of PAZ with HSA occurred via the static quenching mechanism. The calculated binding number and binding constants were 1.041 and 1.436 × 106 M−1, respectively, at 298.15 K based on fluorescence screening. The high binding constant and calculated Gibbs free energy at different temperatures showed spontaneous and strong binding. Circular dichroism measurements showed that the α-helix structure of HSA was retained as the secondary structure, with a slight reduction in its percentage after adding PAZ. Furthermore, molecular modeling studies suggested that the docking score of PAZ is higher than those of bicalutamide and ibuprofen, the drugs that were chosen as model competitors against PAZ. Accordingly, PAZ was found to replace bicalutamide and ibuprofen on the HSA binding site, which was also confirmed by UV absorption spectroscopy.","PeriodicalId":7829,"journal":{"name":"Analytica","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78033378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0