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Blood-brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein-β in patients with subcortical small-vessel disease. 皮层下小血管疾病患者的血脑屏障功能障碍和脑脊液中可溶性淀粉样前体蛋白-β水平降低。
IF 4
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 2022-03-25 eCollection Date: 2022-01-01 DOI: 10.1002/dad2.12296
Petronella Kettunen, Maria Bjerke, Carl Eckerström, Michael Jonsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Anders Wallin
{"title":"Blood-brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein-β in patients with subcortical small-vessel disease.","authors":"Petronella Kettunen, Maria Bjerke, Carl Eckerström, Michael Jonsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Anders Wallin","doi":"10.1002/dad2.12296","DOIUrl":"10.1002/dad2.12296","url":null,"abstract":"<p><strong>Introduction: </strong>Subcortical small-vessel disease (SSVD) is the most common vascular cognitive disorder. However, because no disease-specific cerebrospinal fluid (CSF) biomarkers are available for SSVD, our aim was to identify such markers.</p><p><strong>Methods: </strong>We included 170 healthy controls and patients from the Gothenburg Mild Cognitive Impairment (MCI) study clinically diagnosed with SSVD dementia, Alzheimer's disease (AD), or mixed AD/SSVD. We quantified CSF levels of amyloid-β (Aβ)<sub>x-38</sub>, Aβ<sub>x-40</sub>, Aβ<sub>x-42</sub>, as well as soluble amyloid precursor protein (sAPP)-α and sAPP-β.</p><p><strong>Results: </strong>sAPP-β was lower in SSVD patients than in AD patients and controls. Receiver-operating characteristic (ROC) analyses showed that sAPP-β moderately separated SSVD from AD and controls. Moreover, the CSF/serum albumin ratio was elevated exclusively in SSVD and could moderately separate SSVD from the other groups in ROC analyses.</p><p><strong>Discussion: </strong>SSVD has a biomarker profile that differs from that of AD and controls, and to some extent also from mixed AD/SSVD, suggesting that signs of blood-brain barrier (BBB) dysfunction and sAPP-β could be additional tools to diagnose SSVD.</p><p><strong>Highlights: </strong>Patients with subcortical small-vessel disease (SSVD) exhibited reduced levels of sAPP-β and disturbances of the blood-brain barrier (BBB).This biochemical pattern is different from that of Alzheimer's disease (AD) and to some degree from that of mixed AD/SSVD.Our findings are speaking in favor of the concept that SSVD is a distinct vascular cognitive disorder (VCD) form.</p>","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"25 1","pages":"e12296"},"PeriodicalIF":4.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73866725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amino acid transmitters in the mammalian central nervous system. 哺乳动物中枢神经系统中的氨基酸递质。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1974-01-01 DOI: 10.1007/3-540-06498-2_3
D R Curtis, G A Johnston
{"title":"Amino acid transmitters in the mammalian central nervous system.","authors":"D R Curtis,&nbsp;G A Johnston","doi":"10.1007/3-540-06498-2_3","DOIUrl":"https://doi.org/10.1007/3-540-06498-2_3","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"69 0","pages":"97-188"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/3-540-06498-2_3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15262816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1120
The adrenergic innervation of the gastrointestinal tract. 胃肠道的肾上腺素能神经支配
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1974-01-01
J B Furness, M Costa
{"title":"The adrenergic innervation of the gastrointestinal tract.","authors":"J B Furness,&nbsp;M Costa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"69 0","pages":"2-51"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15470830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of fatty-acid synthesis in higher animals. 高等动物脂肪酸合成的调控。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1974-01-01 DOI: 10.1007/3-540-06498-2_2
Shosaku Numa
{"title":"Regulation of fatty-acid synthesis in higher animals.","authors":"Shosaku Numa","doi":"10.1007/3-540-06498-2_2","DOIUrl":"https://doi.org/10.1007/3-540-06498-2_2","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"3 1","pages":"54-96"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73471882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The adrenergic innervation of the gastrointestinal tract. 胃肠道的肾上腺素能神经支配
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1974-01-01 DOI: 10.1007/3-540-06498-2_1
J. Furness, M. Costa
{"title":"The adrenergic innervation of the gastrointestinal tract.","authors":"J. Furness, M. Costa","doi":"10.1007/3-540-06498-2_1","DOIUrl":"https://doi.org/10.1007/3-540-06498-2_1","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"16 1","pages":"2-51"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87778767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 261
Regulation of fatty-acid synthesis in higher animals. 高等动物脂肪酸合成的调控。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1974-01-01
S Numa
{"title":"Regulation of fatty-acid synthesis in higher animals.","authors":"S Numa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"69 0","pages":"54-96"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15261468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanism of blood coagulation. 血液凝固的机制。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1973-01-01 DOI: 10.1007/3-540-06238-6_4
P A Owren, H Stormorken
{"title":"The mechanism of blood coagulation.","authors":"P A Owren,&nbsp;H Stormorken","doi":"10.1007/3-540-06238-6_4","DOIUrl":"https://doi.org/10.1007/3-540-06238-6_4","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"68 ","pages":"1-53"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/3-540-06238-6_4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15694550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The cell surface in cell interactions. 细胞相互作用中的细胞表面。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1973-01-01 DOI: 10.1007/3-540-06238-6_6
R S Turner, M M Burger
{"title":"The cell surface in cell interactions.","authors":"R S Turner,&nbsp;M M Burger","doi":"10.1007/3-540-06238-6_6","DOIUrl":"https://doi.org/10.1007/3-540-06238-6_6","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"68 ","pages":"121-55"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15683951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs. 可兴奋组织对药物的结后超敏感和亚敏感。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1973-01-01 DOI: 10.1007/3-540-06238-6_5
W W Fleming, J J McPhillips, D P Westfall
{"title":"Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs.","authors":"W W Fleming,&nbsp;J J McPhillips,&nbsp;D P Westfall","doi":"10.1007/3-540-06238-6_5","DOIUrl":"https://doi.org/10.1007/3-540-06238-6_5","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"68 ","pages":"55-119"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15683952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 202
The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. 单胺类和含乙酰胆碱的神经元在调节睡眠-觉醒周期中的作用。
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie Pub Date : 1972-01-01 DOI: 10.1007/3-540-05462-6_2
M Jouvet
{"title":"The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle.","authors":"M Jouvet","doi":"10.1007/3-540-05462-6_2","DOIUrl":"https://doi.org/10.1007/3-540-05462-6_2","url":null,"abstract":"","PeriodicalId":78248,"journal":{"name":"Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie","volume":"64 ","pages":"166-307"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/3-540-05462-6_2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15510320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1086
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