Analytical chemistry, an Indian journal最新文献

Assessment Of Some Heavy Metals As Contaminants In Petroleum Contaminated Soils Of Eleme, Port Harcourt Nigeria 尼日利亚哈科特港Eleme石油污染土壤中重金属污染评价

Analytical chemistry, an Indian journal Pub Date : 2021-08-31 DOI: 10.5281/ZENODO.5335980

U. Ojukwu, A. Eboatu

引用次数: 0

Quantitative determination of citalopramhydrobromide by spectrophotometry and chemometry in presence of its degradation productsand additives in pharmaceutical preparation 盐酸西酞普兰在药物制剂中降解产物和添加剂存在下的分光光度法和化学计量法定量测定

Analytical chemistry, an Indian journal Pub Date : 2016-01-01 DOI: 10.15242/iicbe.c0715105

HeshamSalem, MarianneNebsen

{"title":"Quantitative determination of citalopramhydrobromide by spectrophotometry and chemometry in presence of its degradation productsand additives in pharmaceutical preparation","authors":"HeshamSalem, MarianneNebsen","doi":"10.15242/iicbe.c0715105","DOIUrl":"https://doi.org/10.15242/iicbe.c0715105","url":null,"abstract":"Simple, accurate, sensitive and validated UV stability-indicating spectrophotometric and chemometric methods were developed for determination of CitalopramHydrobromide (CT) in presence of its alkaline, oxidative degradation products and in its pharmaceutical preparation. Method (A) is a successive derivative ratio spectrophotometricone, which depends on the successive derivative of ratio spectra in two steps andmeasuring Citalopram Hydrobromide at 277nmand 293nm.Method (B) ismean centering of ratio spectra which dependson using the mean centered ratio spectra in two successive steps and measuring the mean centeredvalues of the second ratio spectra at 237nm and method (C) used two chemometric techniques ; principal component regression(PCR) and partial least-squares (PLS). The proposed methods werechecked using laboratory-prepared mixtures and were successfully applied for the analysis of pharmaceuticalformulation containing Citalopram Hydrobromide. The proposed methods were validated according to the ICH guidelines. The obtained results were statistically comparedwith those obtained froma compendialHPLCmethod, showing no significant difference with respect to accuracy and precision.","PeriodicalId":7823,"journal":{"name":"Analytical chemistry, an Indian journal","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76745241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation for reverse phase high performance liquid chromatographic method for simultaneously determination for diphenoxylic acid, nitrileamide and bromdiphenyl butoro nitrile in diphenoxylate hydrochloride bulk drug 反相高效液相色谱法同时测定盐酸地苯氧酸原料药中二苯氧酸、腈酰胺和溴二苯丁腈的方法建立与验证

Analytical chemistry, an Indian journal Pub Date : 2012-08-31 DOI: 10.5923/j.fs.20120202.01

R.S.Lokh, P.U.Singare, P. Jadhav

{"title":"Development and validation for reverse phase high performance liquid chromatographic method for simultaneously determination for diphenoxylic acid, nitrileamide and bromdiphenyl butoro nitrile in diphenoxylate hydrochloride bulk drug","authors":"R.S.Lokh, P.U.Singare, P. Jadhav","doi":"10.5923/j.fs.20120202.01","DOIUrl":"https://doi.org/10.5923/j.fs.20120202.01","url":null,"abstract":"Related substances by HPLC method was developed and validated for Diphenoxylate hydrochloride bulk drug and its three potential impurities i.e. Diphenoxylic acid (degradation product), Nitrile amide (precursor) and Bromo Diphenyl butro nitrile (precursor). Analysis was performed on AGILENT 1100 SERIES HPLC system with auto injector and binary gradient high pressure mixing pump on Inersil ODS-3 (RP C 18) column. Mobile phase of Acetonitrile and HPLC water pH adjusted to 2.3 with orthophosphoric acid in the ratio of 25:75 (v/v) with change in the ratio of mobile phase by linear gradient to 85: 25 (v/v) in 45 minute was pumped at 2mL/min and the detection was done at 210 nm. The parameter for which the method was validated included specificity, limit of detection and quantitation, linearity, precision, accuracy and robustness. The method was successfully used to quantitate the levels known impurities {i.e. Diphenoxylic acid (degradation product), Nitrileamide (precursor) and Bromo Diphenyl butro nitrile (precursor)} and unkown impurities in Diphenoxylate hydro- chloride bulk drug.","PeriodicalId":7823,"journal":{"name":"Analytical chemistry, an Indian journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81172143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse Phase Extraction Chromatographic Separation of Trivalent Bismuth Using Liquid Anion Exchanger 液体阴离子交换剂反相萃取色谱分离三价铋

Analytical chemistry, an Indian journal Pub Date : 2012-01-01 DOI: 10.1007/978-90-481-8650-1_13

S. R. Phule, H. Aher, S. Lawande, S. Kuchekar

引用次数: 2

RP HPLC determination of benzhexol hydrochloride in tablet formulations and urine 反相高效液相色谱法测定盐酸苯哲索片剂和尿液中的含量

Analytical chemistry, an Indian journal Pub Date : 2010-12-01 DOI: 10.21608/ABSB.2010.7380

R. Farag, Ashraf M. Ahmed

引用次数: 0