Deutsche Zeitschrift fur Nervenheilkunde最新文献

Icon arrays reduce concern over COVID-19 vaccine side effects: a randomized control study. 图标阵列可减少对 COVID-19 疫苗副作用的担忧：一项随机对照研究。

IF 3.4

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2022-05-07 DOI: 10.1186/s41235-022-00387-5

Madison Fansher, Tyler J Adkins, Poortata Lalwani, Aysecan Boduroglu, Madison Carlson, Madelyn Quirk, Richard L Lewis, Priti Shah, Han Zhang, John Jonides

{"title":"Icon arrays reduce concern over COVID-19 vaccine side effects: a randomized control study.","authors":"Madison Fansher, Tyler J Adkins, Poortata Lalwani, Aysecan Boduroglu, Madison Carlson, Madelyn Quirk, Richard L Lewis, Priti Shah, Han Zhang, John Jonides","doi":"10.1186/s41235-022-00387-5","DOIUrl":"10.1186/s41235-022-00387-5","url":null,"abstract":"On April 13, 2021, the CDC announced that the administration of Johnson and Johnson's COVID-19 vaccine would be paused due to a rare blood clotting side effect in ~ 0.0001% of people given the vaccine. Most people who are hesitant to get a COVID-19 vaccine list potential side effects as their main concern (PEW, 2021); thus, it is likely that this announcement increased vaccine hesitancy among the American public. Two days after the CDC's announcement, we administered a survey to a group of 2,046 Americans to assess their changes in attitudes toward COVID-19 vaccines. The aim of this study was to investigate whether viewing icon arrays of side effect risk would prevent increases in COVID-19 vaccine hesitancy due to the announcement. We found that using icon arrays to illustrate the small chance of experiencing the blood clotting side effect significantly prevented increases in aversion toward the Johnson and Johnson vaccine as well as all other COVID-19 vaccines.","PeriodicalId":78227,"journal":{"name":"Deutsche Zeitschrift fur Nervenheilkunde","volume":"150 1","pages":"38"},"PeriodicalIF":3.4,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73233166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L'exercice contre la maladie artérielle périphérique. 运动预防外周动脉疾病。

IF 3.1

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2022-04-01 DOI: 10.46747/cfp.6804278

Arthur A Qi, Christina S Korownyk

引用次数: 0

MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading. MRX 增加染色质在停滞复制叉处的可及性，促进新生 DNA 的切除和凝聚素的加载。

IF 16

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2020-01-16 Epub Date: 2019-11-20 DOI: 10.1016/j.molcel.2019.10.029

Axel Delamarre, Antoine Barthe, Christophe de la Roche Saint-André, Pierre Luciano, Romain Forey, Ismaël Padioleau, Magdalena Skrzypczak, Krzysztof Ginalski, Vincent Géli, Philippe Pasero, Armelle Lengronne

{"title":"MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading.","authors":"Axel Delamarre, Antoine Barthe, Christophe de la Roche Saint-André, Pierre Luciano, Romain Forey, Ismaël Padioleau, Magdalena Skrzypczak, Krzysztof Ginalski, Vincent Géli, Philippe Pasero, Armelle Lengronne","doi":"10.1016/j.molcel.2019.10.029","DOIUrl":"10.1016/j.molcel.2019.10.029","url":null,"abstract":"The recovery of stalled replication forks depends on the controlled resection of nascent DNA and on the loading of cohesin. These processes operate in the context of nascent chromatin, but the impact of nucleosome structure on a fork restart remains poorly understood. Here, we show that the Mre11-Rad50-Xrs2 (MRX) complex acts together with the chromatin modifiers Gcn5 and Set1 and the histone remodelers RSC, Chd1, and Isw1 to promote chromatin remodeling at stalled forks. Increased chromatin accessibility facilitates the resection of nascent DNA by the Exo1 nuclease and the Sgs1 and Chl1 DNA helicases. Importantly, increased ssDNA promotes the recruitment of cohesin to arrested forks in a Scc2-Scc4-dependent manner. Altogether, these results indicate that MRX cooperates with chromatin modifiers to orchestrate the action of remodelers, nucleases, and DNA helicases, promoting the resection of nascent DNA and the loading of cohesin, two key processes involved in the recovery of arrested forks.","PeriodicalId":78227,"journal":{"name":"Deutsche Zeitschrift fur Nervenheilkunde","volume":"182 1","pages":"395-410.e3"},"PeriodicalIF":16.0,"publicationDate":"2020-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molcel.2019.10.029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73257153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Vorstandswahlen

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2019-04-01 DOI: 10.1007/BF01653004

O. Foerster, H. Curschmann, K. Mendel

引用次数: 0

easyGWAS: A Cloud-Based Platform for Comparing the Results of Genome-Wide Association Studies. easyGWAS：比较全基因组关联研究结果的云平台。

IF 11.6

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2017-01-01 Epub Date: 2016-12-16 DOI: 10.1105/tpc.16.00551

Dominik G Grimm, Damian Roqueiro, Patrice A Salomé, Stefan Kleeberger, Bastian Greshake, Wangsheng Zhu, Chang Liu, Christoph Lippert, Oliver Stegle, Bernhard Schölkopf, Detlef Weigel, Karsten M Borgwardt

{"title":"easyGWAS: A Cloud-Based Platform for Comparing the Results of Genome-Wide Association Studies.","authors":"Dominik G Grimm, Damian Roqueiro, Patrice A Salomé, Stefan Kleeberger, Bastian Greshake, Wangsheng Zhu, Chang Liu, Christoph Lippert, Oliver Stegle, Bernhard Schölkopf, Detlef Weigel, Karsten M Borgwardt","doi":"10.1105/tpc.16.00551","DOIUrl":"10.1105/tpc.16.00551","url":null,"abstract":"The ever-growing availability of high-quality genotypes for a multitude of species has enabled researchers to explore the underlying genetic architecture of complex phenotypes at an unprecedented level of detail using genome-wide association studies (GWAS). The systematic comparison of results obtained from GWAS of different traits opens up new possibilities, including the analysis of pleiotropic effects. Other advantages that result from the integration of multiple GWAS are the ability to replicate GWAS signals and to increase statistical power to detect such signals through meta-analyses. In order to facilitate the simple comparison of GWAS results, we present easyGWAS, a powerful, species-independent online resource for computing, storing, sharing, annotating, and comparing GWAS. The easyGWAS tool supports multiple species, the uploading of private genotype data and summary statistics of existing GWAS, as well as advanced methods for comparing GWAS results across different experiments and data sets in an interactive and user-friendly interface. easyGWAS is also a public data repository for GWAS data and summary statistics and already includes published data and results from several major GWAS. We demonstrate the potential of easyGWAS with a case study of the model organism Arabidopsis thaliana, using flowering and growth-related traits.","PeriodicalId":78227,"journal":{"name":"Deutsche Zeitschrift fur Nervenheilkunde","volume":"68-69 1","pages":"5-19"},"PeriodicalIF":11.6,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73405316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental trends in alcohol use initiation and escalation from early to middle adolescence: Prediction by urgency and trait affect. 从青春期早期到中期，开始饮酒和饮酒升级的发展趋势：通过紧迫感和特质情感进行预测。

IF 3.4

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2016-08-01 Epub Date: 2016-03-31 DOI: 10.1037/adb0000173

Hector I Lopez-Vergara, Nichea S Spillane, Jennifer E Merrill, Kristina M Jackson

{"title":"Developmental trends in alcohol use initiation and escalation from early to middle adolescence: Prediction by urgency and trait affect.","authors":"Hector I Lopez-Vergara, Nichea S Spillane, Jennifer E Merrill, Kristina M Jackson","doi":"10.1037/adb0000173","DOIUrl":"10.1037/adb0000173","url":null,"abstract":"Studies on adolescent drinking have not always been able to distinguish between initiation and escalation of drinking, because many studies include samples in which initiation has already occurred; hence, initiation and escalation are often confounded. The present study draws from a dual-process theoretical framework to investigate: if changes in the likelihood of drinking initiation and escalation are predicted by a tendency toward rash action when experiencing positive and negative emotions (positive and negative urgency) and whether trait positive and negative affect moderate such effects. Alcohol naïve adolescents (n = 944; age M = 12.16, SD = .96; 52% female) completed 6 semiannual assessments of trait urgency and affect (Wave 1) and alcohol use (Waves 2-6). A 2-part random-effects model was used to estimate changes in the likelihood of any alcohol use versus escalation in the volume of use among initiators. Main effects suggest a significant association between positive affect and change in level of alcohol use among initiators, such that lower positive affect predicted increased alcohol involvement. This main effect was qualified by a significant interaction between positive urgency and positive affect predicting changes in the escalation of drinking, such that the effect of positive urgency was augmented for those high on trait positive affect, though only at extremely high levels of positive affect. Results suggest risk factors in the development of drinking depend on whether initiation or escalation is investigated. A more nuanced understanding of the early developmental phases of alcohol involvement can inform prevention and intervention efforts. (PsycINFO Database Record","PeriodicalId":78227,"journal":{"name":"Deutsche Zeitschrift fur Nervenheilkunde","volume":"68-69 1","pages":"578-587"},"PeriodicalIF":3.4,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73405008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors of problematic internet use and the associated psychological distress among graduate students of Bangladesh. 孟加拉国研究生使用问题互联网的普遍性、风险因素及相关心理困扰。

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2016-01-01 Epub Date: 2016-11-25 DOI: 10.1186/s40405-016-0020-1

Md Azharul Islam, Muhammad Zakir Hossin

{"title":"Prevalence and risk factors of problematic internet use and the associated psychological distress among graduate students of Bangladesh.","authors":"Md Azharul Islam, Muhammad Zakir Hossin","doi":"10.1186/s40405-016-0020-1","DOIUrl":"10.1186/s40405-016-0020-1","url":null,"abstract":"A growing body of epidemiological literature suggests that problematic Internet use (PIU) is associated with a range of psychological health problems in adolescents and young adults. This study aimed to explore socio-demographic and behavioural correlates of PIU and examine its association with psychological distress. A total of 573 graduate students from Dhaka University of Bangladesh responded to a self-administered questionnaire that included internet addiction test (IAT), 12-items General Health Questionnaire and a set of socio-demographic and behavioural factors. The study found that nearly 24% of the participants displayed PIU on the IAT scale. The prevalence of PIU significantly varied depending on gender, socioeconomic status, smoking habit and physical activity (p < 0.05). The multiple regression analyses suggested that PIU is strongly associated with psychological distress regardless of all other explanatory variables (adjusted OR 2.37, 95% CI 1.57, 3.58). Further research is warranted to confirm this association by employing prospective study designs.","PeriodicalId":78227,"journal":{"name":"Deutsche Zeitschrift fur Nervenheilkunde","volume":"130 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73516437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rivista sperimentale di Freniatria 前沿医学实验杂志

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2006-01-01 DOI: 10.1007/BF02549991

R. Passione

引用次数: 5

Die Erhöhung der γ-Globuline im Liquor 增加γ-Globuline在酒业

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2006-01-01 DOI: 10.1007/BF02388074

H. Matiar, C. Schmidt

引用次数: 0

Zur Klinik und Pathomorphologie der polyradiculomyclitischen Verlaufsform des Zoster 到郊外多放射病毒的临床及病原体学

Deutsche Zeitschrift fur Nervenheilkunde Pub Date : 2006-01-01 DOI: 10.1007/BF02388075

A. Stammler, G. Struck

引用次数: 3