Anasthesie, Intensivtherapie, Notfallmedizin最新文献_第3页

[Characteristics of cerebral blood flow and the electroencephalogram during experimental malignant hyperthermia]. [实验性恶性热疗期间脑血流及脑电图特征]。

Anasthesie, Intensivtherapie, Notfallmedizin Pub Date : 1990-10-01

E Kochs, H Nollen, J Schulte am Esch

{"title":"[Characteristics of cerebral blood flow and the electroencephalogram during experimental malignant hyperthermia].","authors":"E Kochs, H Nollen, J Schulte am Esch","doi":"","DOIUrl":"","url":null,"abstract":"It is generally assumed that the brain is not primarily involved in the development of a malignant hyperthermia syndrome (MH). However, spontaneous brain electrical activity (EEG) has not been related temporally to the development of haemodynamic, respiratory and metabolic changes during a fulminant MH crisis. In the present study cerebral blood flow (CBF) and spontaneous electroencephalogram (EEG) were recorded in 8 pigs susceptible (MHS) for the development of malignant hyperthermia and 8 non-susceptible pigs (nMHS) after exposure to 1% halothane. Power densities in selected frequency bands were calculated from the EEG. Additionally, body temperature and haemodynamic and blood gas parameters were studied over a period of 60 min. MH was triggered in all MHS animals. Following exposure to halothane initial EEG changes were noted after 20 to 30 min. They consisted of a decrease in total power and a shift to lower frequencies (delta-theta activity). At this time, CBF was significantly increased compared to control. In 4 animals an isoelectric EEG was noted at a PaO2 of 65-78 mmHg and PaCO2 of 52 to 64 mmHg. Characteristic changes for the development of an MH syndrome in haemodynamic and respiratory parameters as well as a rise in body temperature occurred after first EEG changes were seen. Our results do not support the hypothesis that early EEG changes during MH occur as a result of systemic hypotension, hypoxaemia, hypercapnia or cerebral ischaemia. Our data indicate that EEG monitoring in combination with monitoring of haemodynamic, respiratory and metabolic parameters may be of value for an early detection of an MH-crisis.","PeriodicalId":7813,"journal":{"name":"Anasthesie, Intensivtherapie, Notfallmedizin","volume":"25 5","pages":"348-53"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13403879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Horst Stoeckel 60 years]. Horst Stoeckel 60岁。

Anasthesie, Intensivtherapie, Notfallmedizin Pub Date : 1990-10-01

引用次数: 0

[The efficiency of prehospital cardiopulmonary resuscitation. Which factors determine the outcome?]. 院前心肺复苏的有效性。哪些因素决定了结果?

Anasthesie, Intensivtherapie, Notfallmedizin Pub Date : 1990-10-01

J Schüttler, A C Bartsch, F Bremer, B J Ebeling, M Födisch, P Kulka, D Pflitsch

{"title":"[The efficiency of prehospital cardiopulmonary resuscitation. Which factors determine the outcome?].","authors":"J Schüttler, A C Bartsch, F Bremer, B J Ebeling, M Födisch, P Kulka, D Pflitsch","doi":"","DOIUrl":"","url":null,"abstract":"Survival rates following cardiopulmonary resuscitation differ widely with regard to the diverse rescue systems where the investigations were performed, and also with regard to the different patient populations. From 1981 to 1986, 1037 patients with out-of-hospital cardiac arrest were investigated in the city of Bonn. It was the purpose of this study to differentiate between various patient populations and to analyze factors which are responsible for CPR success. Survival rates following CPR could be increased from 8% in 1981 to 23% in 1984. Thereafter, a relatively stable survival rate of 20.1 +/- 1.7% with an initial CPR success rate of 62.5 +/- 8.1% was observed. Patients with ventricular fibrillation showed significantly higher survival rates (33.2 +/- 2.9%) when compared to asystolic victims (11.3 +/- 1.9%). The worst results were seen in these patients where CPR was initiated following trauma (8%) or in paediatric patients (8%). Factors which significantly determine survival following CPR are: initial ECG finding, therapeutic delay with regard to bystander-initiated basic life support, as well as advanced life support by emergency physicians. In addition, well standardized therapeutical strategies are of importance with early defibrillation, rapid endotracheal intubation and swift epinephrine application mostly by endobronchial administration.","PeriodicalId":7813,"journal":{"name":"Anasthesie, Intensivtherapie, Notfallmedizin","volume":"25 5","pages":"340-7"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13403934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clonidine supplemented analgesia and sedation in prevention of postoperative delirium]. [可乐定加镇痛镇静预防术后谵妄]。