Analytical Letters最新文献

Quantitation of Arsenic in biological matrices: Use of Sector Field Inductively Coupled Plasma-Mass Spectrometry for Improved Accuracy and Specificity. 生物基质中砷的定量：使用扇形场电感耦合等离子体质谱法提高准确性和特异性。

IF 1.8 4区化学

Analytical Letters Pub Date : 2025-04-29 DOI: 10.1080/00032719.2025.2496934

Chamindu Liyanapatirana, Frank X Weber, James M Harrington, Laura G Haines, Reshan A Fernando, Keith E Levine, Suramya Waidyanatha

{"title":"Quantitation of Arsenic in biological matrices: Use of Sector Field Inductively Coupled Plasma-Mass Spectrometry for Improved Accuracy and Specificity.","authors":"Chamindu Liyanapatirana, Frank X Weber, James M Harrington, Laura G Haines, Reshan A Fernando, Keith E Levine, Suramya Waidyanatha","doi":"10.1080/00032719.2025.2496934","DOIUrl":"https://doi.org/10.1080/00032719.2025.2496934","url":null,"abstract":"Arsenic (As) and As-containing compounds have a wide array of applications in medicine, industry, and agriculture and has been associated with adverse health outcomes. In support of studies investigating the toxicity and toxicokinetic behavior of arsenic compounds, we developed and validated a high-resolution sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) method to quantitate total arsenic in Sprague-Dawley (SD) rat plasma and heart. Primary matrix standard curves prepared in male SD rat plasma were linear (r ≥ 0.999) over the range of 5 to 1250 ng As/mL plasma with accuracy determined as relative error (RE) was ≤ ±20% at the lower limit of quantitation (LLOQ) of 5 ng/mL and ≤ ±15% for all other concentrations. The method limit of detection (LOD) was 0.728 ng/mL plasma. Mean extraction recovery was 96.7%, with a relative standard deviation (RSD) of 4.0%. The method demonstrated acceptable inter- (≤ ±7.3% RE and ≤ 8.0% RSD) and intra-day (≤ ±14.9% RE and ≤ 6.8% RSD) accuracy and precision. Method selectivity was ≤ 20% of the response for the LLOQ. Method performance was also evaluated in SD rat heart by preparing QC samples in heart homogenate and quantifying using plasma calibration curve. The mean RE value was -3.8% and the RSD value was 3.4% demonstrating that the method is suitable for quantitation of arsenic in rat heart.","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12383451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Rapid Fluorescence Probe for the Determination of Aqueous Hypochlorite. 快速荧光探针测定次氯酸盐的研究。

IF 1.8 4区化学

Analytical Letters Pub Date : 2025-01-01 Epub Date: 2024-09-17 DOI: 10.1080/00032719.2024.2403144

Sharmin Sultana, Megan B Guetzloff, Ramu Kakumanu, Trevor R Ostlund, Fathi T Halaweish, Brian A Logue

{"title":"Development of a Rapid Fluorescence Probe for the Determination of Aqueous Hypochlorite.","authors":"Sharmin Sultana, Megan B Guetzloff, Ramu Kakumanu, Trevor R Ostlund, Fathi T Halaweish, Brian A Logue","doi":"10.1080/00032719.2024.2403144","DOIUrl":"10.1080/00032719.2024.2403144","url":null,"abstract":"Chlorine interacts with the aqueous environment, including the mucosa and alveolar fluid in the lungs, causes the immediate transformation of chlorine to hypochlorous acid (HClO) and hydrochloric acid (HCl) which induces cellular damage and may produce systemic toxicity. There are multiple techniques to monitor hypochlorite (HClO/ClO-) from various matrices, however, they each have significant disadvantages, including limited sensitivity, complexity, and slow response. In this study, we developed a water-soluble fluorescein-based probe, called fluorescein thioacid (FSH), for the rapid and sensitive detection of HClO/ClO- in aqueous solutions via oxidation of FSH to produce fluorescein. FSH was synthesized via a simple, one-step procedure and exhibited excellent selectivity for ClO-, maintaining 82% signal stability for 24 h. FSH performed well over a wide pH range (4 to 10; optimum pH of 4), produced a linear range from 1 to 100 μM, and had a detection limit of 100 nM. The probe was able to accurately quantify HClO/ClO- concentrations in tap water (13.8 μM) and swimming pool water (56.9 μM) samples. Overall, FSH is simple to synthesize, highly selective, highly sensitive, has excellent water solubility, and produces a fast response for monitoring of aqueous ClO- levels.","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"58 13","pages":"2249-2263"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Part-per-Billion (Ppb)-Level Acetylene Sensor Employing Optical Quartz Enhanced Photoacoustic Spectroscopy (QEPAS) with an Erbium-Doped Fiber Amplifier (EDFA) and a Fiber-Optic Fabry–Perot Interferometer 采用光学石英增强型光声光谱仪 (QEPAS)、掺铒光纤放大器 (EDFA) 和光纤法布里-珀罗干涉仪的十亿分之一 (Ppb) 级乙炔传感器

IF 2 4区化学

Analytical Letters Pub Date : 2024-09-14 DOI: 10.1080/00032719.2024.2403020

Cheng Lin, Xuelian Zhang, Xueyang Yan, Yan Cai, Wenjie Li