Journal of clinical and hospital pharmacy最新文献_第4页

The prevention of poisoning in childhood. 预防儿童中毒。

Journal of clinical and hospital pharmacy Pub Date : 1981-06-01 DOI: 10.1111/j.1365-2710.1981.tb00980.x

H H Woolfson

引用次数: 0

A mathematical model of drug absorption. 药物吸收的数学模型。

Journal of clinical and hospital pharmacy Pub Date : 1981-06-01 DOI: 10.1111/j.1365-2710.1981.tb00983.x

B C Goodacre, P J Murray

引用次数: 19

Awareness of potential drug interactions with anticoagulants. 了解抗凝剂与药物的潜在相互作用。

Journal of clinical and hospital pharmacy Pub Date : 1981-06-01 DOI: 10.1111/j.1365-2710.1981.tb00985.x

J R Williams, J P Griffin, P F D'Arcy, W C Bowman

引用次数: 0

Disposition of pethidine in man under acidic urinary PH. I. Plasma level and urinary elimination of pethidine and norpethidine. 酸性尿ph下哌替啶在人体内的分布。血浆水平和尿中哌替啶和去甲哌替啶的消除。

Journal of clinical and hospital pharmacy Pub Date : 1981-06-01 DOI: 10.1111/j.1365-2710.1981.tb00982.x

K Chan

{"title":"Disposition of pethidine in man under acidic urinary PH. I. Plasma level and urinary elimination of pethidine and norpethidine.","authors":"K Chan","doi":"10.1111/j.1365-2710.1981.tb00982.x","DOIUrl":"https://doi.org/10.1111/j.1365-2710.1981.tb00982.x","url":null,"abstract":"A detailed study on the plasma and urine levels of pethidine and its major basic metabolite, norpethidine, was carried out after intravenous and oral administration of pethidine, under conditions of controlled acidic urinary pH, to two healthy subjects who had previously shown significant difference in the urinary recovery of pethidine after the intramuscular administration of a standard dose. Utilizing the data of area under plasma concentration-time curve and cumulative urinary excretion of pethidine, similar values of renal clearance of the drug were obtained after separate intravenous and oral administration to the same subject. There is an overall difference in the renal clearance and metabolic pattern of the drug between these two subjects under conditions of controlled acidic urinary pH. It is postulated that variation in the overall elimination of pethidine and other weakly basic drugs can only be elucidated under conditions and may be interpreted in terms of differences in the renal clearance and hepatic biotransformation of the drug.","PeriodicalId":77862,"journal":{"name":"Journal of clinical and hospital pharmacy","volume":"6 2","pages":"107-16"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2710.1981.tb00982.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18357616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The solid state stability of oral rehydration salts. 口服补液盐的固态稳定性。

Journal of clinical and hospital pharmacy Pub Date : 1981-06-01 DOI: 10.1111/j.1365-2710.1981.tb00984.x

E Izgü, T Baykara

{"title":"The solid state stability of oral rehydration salts.","authors":"E Izgü, T Baykara","doi":"10.1111/j.1365-2710.1981.tb00984.x","DOIUrl":"https://doi.org/10.1111/j.1365-2710.1981.tb00984.x","url":null,"abstract":"The stability of rehydration salts (Electrolyte Powder B.P.C.) used in the treatment of infantile diarrhoea and cholera, was investigated by examining the discolouration of the salts under different conditions. Colourimetric measurements were obtained with a reflectometer. Browning reactions in the electrolyte solutions were followed by absorption at 284 nm and by the thiobarbituric acid reaction at 443 nm. The original white colour of the mixture began to turn yellow during the second week of exposure at 50 +/- 1 degree C under human conditions. Storage at room temperature caused discolouration only after four weeks. Of the three Hunter's values L, a, b the degree of b increased significantly. Discolouration of the mixture was accompanied by spectral changes. The peaks of the spectra shifted uniformly but did not reach 284 nm. The plot of Hunter's L, a, b against time indicated that decomposition of glucose in the powder into early intermediates followed apparent zero order kinetics. Polymerisation of these intermediates after prolonged storage under adverse conditions is a possibility. It is therefore justifiable to conclude that the rehydration salts should be prepared extemporaneously when required unless strict storage conditions are adhered to.","PeriodicalId":77862,"journal":{"name":"Journal of clinical and hospital pharmacy","volume":"6 2","pages":"135-44"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2710.1981.tb00984.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18357618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Adverse drug reactions. 药物不良反应。

Journal of clinical and hospital pharmacy Pub Date : 1900-01-01 DOI: 10.1007/978-3-642-00663-0

L. Beeley, F. Beadle, N. Ballantine

引用次数: 1