Anesthesia and analgesia最新文献

{"title":"Anticoagulation Timing Risk Stratification in Traumatic Brain Injury: Online Tool for Real-Time Hazard Ratios and Phenotypes.","authors":"Andrew J Warburton, Mahesh K Challapalli, Daniel Katz","doi":"10.1213/ANE.0000000000008105","DOIUrl":"10.1213/ANE.0000000000008105","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"1162-1163"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Impact of Time Pressure in Regional Anesthesia: A Prospective Randomized Simulation-Based Study.","authors":"Felix-Olivier Lessard, Issam Tanoubi, Rami Issa, Julie Blain, Marie-Eve Bélanger","doi":"10.1213/ANE.0000000000008108","DOIUrl":"10.1213/ANE.0000000000008108","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"1164-1166"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1's Shadowy Embers.","authors":"Todd Nelson","doi":"10.1213/ANE.0000000000008001","DOIUrl":"10.1213/ANE.0000000000008001","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"1167"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes, Predictors, and Treatment of Vasoplegia in Cardiac Surgery: A Narrative Review.","authors":"Ahmed S Awad, Adam S Mangold, Ana Ainechi, Ludmil V Mitrev","doi":"10.1213/ANE.0000000000008086","DOIUrl":"10.1213/ANE.0000000000008086","url":null,"abstract":"<p><p>Vasoplegia is a form of distributive shock that commonly occurs after cardiac surgery involving cardiopulmonary bypass. Although a formal definition does not exist, it is generally characterized by low systemic vascular resistance with a maintained or elevated cardiac index that tends to be resistant to treatment with fluid or vasopressor. Postoperative vasoplegia in cardiac surgery patients is associated with increased morbidity and mortality. This article reviews the current understanding of the pathophysiology of vasoplegia in cardiac surgery, including risk factors for its development, and evolving strategies for prediction, diagnosis, and treatment. Prominent preoperative risk factors include patient demographics (older age, male sex, elevated body mass index), comorbid conditions (heart failure with reduced ejection fraction, chronic kidney disease, anemia, infective endocarditis, hemodynamic instability, thyroid dysfunction, diabetes mellitus, tobacco use), medications (renin-angiotensin-aldosterone axis blockers, calcium channel blockers, beta-blockers, inotropes, antiplatelets and anticoagulants, amiodarone, diuretics, anesthetic agents), and the type of surgical procedure performed. Prominent intraoperative risk factors include the use of cardiopulmonary bypass, blood product transfusion, and poor temperature control. Multiple biomarkers and dynamic monitoring systems are being studied as predictors for the development of vasoplegia. An overview of available treatments is presented along with up-to-date evidence supporting their use in multimodal vasopressor regimens.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"1049-1061"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148215941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Expanded Departmental Nomenclature Enhance or Obscure Anesthesiology's Identity?","authors":"Rafael Ortega, Kevin Fung Cai, Hanzhang Zhao","doi":"10.1213/ANE.0000000000008267","DOIUrl":"10.1213/ANE.0000000000008267","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"e74-e75"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Depression after Perioperative Methadone Administration: A Systematic Review and Meta-analysis.","authors":"Eduardo Nunez-Rodriguez, Guido Mazzinari, Sarah Lumsden, Nicolas A Cortes-Mejia, Kate J Krause, Evan D Kharasch, Juan P Cata","doi":"10.1213/ANE.0000000000008077","DOIUrl":"10.1213/ANE.0000000000008077","url":null,"abstract":"<p><strong>Background: </strong>Despite evidence supporting methadone analgesic efficacy, perioperative methadone use remains limited due to concerns regarding respiratory depression. The aim of this systematic review and meta-analysis is to objectively evaluate the current evidence on the association between perioperative intravenous methadone administration and postoperative respiratory depression, compared with other opioids. 1.</p><p><strong>Methods: </strong>Ovid MEDLINE, Ovid Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus were searched from January 1, 1970 to April 5, 2025. Eligible studies were randomized clinical trials (RCT) and retrospective studies comparing perioperative intravenous methadone administration with other opioids in adult or pediatric surgical patients and reporting postoperative respiratory depression events. Summary estimates were calculated as relative risks with a 95% confidence interval for the main analysis. The primary outcome was postoperative respiratory depression, defined as naloxone use, respiratory rate <8 breaths per minute, or SpO 2 <90%.</p><p><strong>Results: </strong>Twenty-five studies comprising 116,815 surgical patients were included. Twelve RCTs (n = 845) contributed data to the primary analysis. Respiratory depression occurred in 7.7% of methadone-treated patients and 6.6% of controls. Methadone was not associated with a significant greater risk of respiratory depression (relative risk [RR] 1.22, 95% confidence interval [CI], 0.76-1.95). Bayesian meta-analysis, subgroup analyses stratified by methadone dose, timing of events, and surgical population, and analyses of retrospective studies did not reveal greater risk of respiratory depression. Certainty of evidence was rated very low due to risk of bias and lack of continuous monitoring strategies in most of the included studies.</p><p><strong>Conclusion: </strong>Perioperative intravenous methadone was not associated with a higher risk of respiratory depression, compared to other opioids. The available evidence is predominantly derived from retrospective datasets, emphasizing the need for prospective studies with rigorous respiratory monitoring to further validate the safety of perioperative intravenous (i.v.) methadone administration.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"1034-1048"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Ethical Considerations in Quality Improvement Research versus Human Subject Research.","authors":"Antonia L Vilella, Jacqueline C Stocking, Maged A Tanios, Rima Bouajram, Jean G Charchaflieh","doi":"10.1213/ANE.0000000000008289","DOIUrl":"https://doi.org/10.1213/ANE.0000000000008289","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"143 5","pages":"e82"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Response.","authors":"Jordan Holloway, Nasir Hussain","doi":"10.1213/ANE.0000000000008276","DOIUrl":"https://doi.org/10.1213/ANE.0000000000008276","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"143 5","pages":"e76-e77"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap: From Statistical Thresholds to Perfusion-Based Targets in Pediatric Anesthesia.","authors":"Shingo Kawashima, Atsushi Kobayashi, Wakana Kawashima, Hiroyuki Kinoshita","doi":"10.1213/ANE.0000000000008279","DOIUrl":"10.1213/ANE.0000000000008279","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"e80-e81"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Misconduct: Inconsistent Consequences.","authors":"","doi":"10.1213/ANE.0000000000008359","DOIUrl":"https://doi.org/10.1213/ANE.0000000000008359","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"143 5","pages":"987"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}