Advances in myocardiology最新文献_第5页

Regulation of pyruvate dehydrogenase complex activity during myocardial ischemia. 心肌缺血时丙酮酸脱氢酶复合物活性的调节。

Advances in myocardiology Pub Date : 1985-01-01

T C Vary, P J Randle

引用次数: 0

A theoretical analysis of the rate of resting metabolism of isolated papillary muscle. 离体乳头肌静息代谢率的理论分析。

Advances in myocardiology Pub Date : 1985-01-01

D Loiselle

引用次数: 0

Absence of a relationship between extracellular potassium accumulation and contractile failure in the ischemic or hypoxic rabbit heart. 缺血或缺氧兔心脏细胞外钾积累与收缩衰竭之间关系的缺失。

Advances in myocardiology Pub Date : 1985-01-01

S C Webb, G G Fleetwood, R A Montgomery, P A Poole-Wilson

{"title":"Absence of a relationship between extracellular potassium accumulation and contractile failure in the ischemic or hypoxic rabbit heart.","authors":"S C Webb, G G Fleetwood, R A Montgomery, P A Poole-Wilson","doi":"","DOIUrl":"","url":null,"abstract":"Ischemia and hypoxia both cause a rapid loss of potassium from myocardial cells. We have investigated the relationship between the accumulation of potassium in the extracellular fluid and the early loss of contractility. Experiments were performed on the isolated rabbit heart perfused with physiological saline at 36 degrees C, paced at 3 Hz. Tension was recorded from the apex. Extracellular potassium concentration [( K+]o) was recorded with small ion-selective electrodes. After the onset of global ischemia, [K+]o rose within 15 sec and reached 9.5 +/- 1.1 mmoles/liter after 5 min. Developed tension (T) fell to 9 +/- 2% of control over the same period. During substrate-free hypoxia, T declined at a similar rate, and [K+]o rose slowly to 5.5 +/- 0.1 mmoles/liter after 5 min. The relationship between [K]o and T during normal perfusion and oxygenation was investigated by incrementally increasing the perfusate [K+]. T dropped to 78.6 +/- 4.5% of control at a [K+]o of 9 mmoles/liter. Comparison of the relationship between [K+]o and T during high-potassium perfusion, ischemia, and hypoxia shows that extracellular potassium accumulation per se makes almost no contribution to the decline of contractile function in ischemia or hypoxia. (Values are means +/- S.E., N = 5.)","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"405-15"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15106647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on experimental coronary insufficiency. Effect of L-carnitine on myocardial ischemia produced by sympathetic-nerve stimulation with high plasma fatty acids. 实验性冠状动脉不全的研究。左旋肉碱对高血浆脂肪酸交感神经刺激引起的心肌缺血的影响。

Advances in myocardiology Pub Date : 1985-01-01

O Iimura, T Shoji, S Yoshida, R Sato, K Nohara, Y Kudoh, N Ishiyama, M Motoe

{"title":"Studies on experimental coronary insufficiency. Effect of L-carnitine on myocardial ischemia produced by sympathetic-nerve stimulation with high plasma fatty acids.","authors":"O Iimura, T Shoji, S Yoshida, R Sato, K Nohara, Y Kudoh, N Ishiyama, M Motoe","doi":"","DOIUrl":"","url":null,"abstract":"Our previous studies revealed that sympathetic-nerve stimulation (SNSt) plays an important role in the precipitation and the augmentation of myocardial ischemia in dogs with coronary constriction. To clarify the underlying mechanism of the detrimental effect of free fatty acids (FFA) at a high plasma concentration and the beneficial effect of L-carnitine on myocardial ischemia, ischemic changes following SNSt were compared among three groups of dogs with mild or moderate coronary constriction: a saline control group, an intralipid [(IL) 0.1 ml/kg per min + heparin 5 mg/kg] group, and an IL + L-carnitine (200 mg/kg) group. High plasma concentration of FFA aggravated the ischemic changes induced by SNSt in dogs with coronary constriction, in which no signs of increase in myocardial oxygen consumption were seen. L-Carnitine clearly alleviated the mechanical dysfunction, acceleration of anaerobic metabolism, depletion of myocardial contents of high-energy phosphates, myocardial accumulation of lactate, and ECG ischemic changes that were augmented by high plasma FFA in the coronary-constricted dogs with SNSt. From these findings, it was suggested that an increased plasma FFA might aggravate myocardial ischemia, at least, produced by SNSt in dogs with mild or moderate coronary constriction and that L-carnitine might improve the ischemia augmented by FFA, presumably by reducing myocardial accumulation of FFA intermediates.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"437-49"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15106649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The measurement of cardiac membrane channels following their incorporation into phospholipid bilayers. 心膜通道掺入磷脂双层后的测量。

Advances in myocardiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4757-1287-2_5

A J Williams

引用次数: 2

Mechanical response of rabbit myocardium and coronary arteries to leukotriene D4. Failure to demonstrate a role in the pathophysiology of hypoxia. 兔心肌和冠状动脉对白三烯D4的机械反应。未能证明其在缺氧病理生理中的作用。

Advances in myocardiology Pub Date : 1985-01-01

M A Tones, L G Letts, G G Fleetwood, P A Poole-Wilson

引用次数: 0

Disturbances of the heart structure and function in chronic hemolytic anemia, their compensation with increased coronary flow, and their prevention with ionol, an inhibitor of lipid peroxidation. 慢性溶血性贫血的心脏结构和功能紊乱，冠状动脉血流增加对它们的补偿，以及脂质过氧化抑制剂离子醇的预防。

Advances in myocardiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4757-1287-2_16

F Z Meerson, M E Evsevieva

{"title":"Disturbances of the heart structure and function in chronic hemolytic anemia, their compensation with increased coronary flow, and their prevention with ionol, an inhibitor of lipid peroxidation.","authors":"F Z Meerson, M E Evsevieva","doi":"10.1007/978-1-4757-1287-2_16","DOIUrl":"https://doi.org/10.1007/978-1-4757-1287-2_16","url":null,"abstract":"The structure and function of heart muscle were studied in rats with chronic hemolytic anemia induced by phenylhydrazine. Contractural lesions, myocytolysis, fatty dystrophy, and small-focal necrosis were found in the myocardium along with hypertrophy. The disturbances were accompanied by a compensatory increase in the coronary flow by 2.5-fold during myocardial contractions. When the coronary flow of isolated hearts was experimentally decreased to the control level, a great depression of the contractile function developed. Administration of the antioxidant ionol, an inhibitor of lipid peroxidation, simultaneously with phenylhydrazine did not prevent the development of the hemolytic anemia, but decreased by 2 times the degree of hypertrophy and the amount of the lesion foci in the heart muscle. It also significantly inhibited the compensatory increase of coronary flow and completely eliminated depression of the heart contractile function during the normalization of coronary flow. The data allow a suggestion that hemolytic anemia is accompanied by activated lipid peroxidation, this process playing a role in the myocardial damage of anemia. Antioxidants can prevent such damage.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"5 ","pages":"201-11"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15082599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Differences in electrical and mechanical recovery from ischemic heart arrest and cardioplegia. 缺血性心脏骤停和心脏停跳后电和机械恢复的差异。

Advances in myocardiology Pub Date : 1985-01-01

J S Juggi, P Braveny, G Telahoun, H J Shuhaiber, A M Yousof

{"title":"Differences in electrical and mechanical recovery from ischemic heart arrest and cardioplegia.","authors":"J S Juggi, P Braveny, G Telahoun, H J Shuhaiber, A M Yousof","doi":"","DOIUrl":"","url":null,"abstract":"The course of recovery of heart activity [assessed by heart rate, atrioventricular (AV) conduction time, monophasic action potentials, contractile force, and perfusion rate] from hypothermic ischemic arrest was studied on isolated perfused rat hearts. The effect of control ischemic arrest was compared with various cardioplegic protective formulations based on high K+ content. During control hypothermic ischemia (20 degrees C), the heart activity extinguished only gradually, action potentials were biphasic, AV conduction was extremely prolonged, and contractions were slow and relatively strong. On reperfusion (37 degrees C), the recovery of electrical activity was almost instantaneous and normalized within 2 min, whereas the contractile force remained substantially depressed. In contrast, K+-containing cardioplegic solutions stopped the heart within several cycles. Postarrest recovery was delayed and transitorily associated with severe arrhythmias (AV block, repetitive afterdepolarizations and oscillations during elevated plateau, and ventricular fibrillation). Nevertheless, the action potentials as well as the contractile force virtually normalized in 10-15 min. Procaine-containing cardioplegic solutions were ineffective in preventing the onset of postarrest reperfusion arrhythmias, whereas addition of nifedipine to the K+-containing cardioplegic solutions largely prevented these arrhythmias, and contractile force was further improved by high concentrations of glucose. The data indicate that postarrest electrical and mechanical recovery do not recover in parallel. Furthermore, high concentrations of calcium antagonist and glucose preserve the electrical and mechanical properties of the cardiac muscle during periods of cardiac arrest.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"491-502"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15103991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impairment of myocardial function induced by particulate contamination of cardioplegic solutions. 心脏麻痹液微粒污染致心肌功能损害。

Advances in myocardiology Pub Date : 1985-01-01

L A Robinson, M V Braimbridge, D J Hearse

{"title":"Impairment of myocardial function induced by particulate contamination of cardioplegic solutions.","authors":"L A Robinson, M V Braimbridge, D J Hearse","doi":"","DOIUrl":"","url":null,"abstract":"The U.S. Pharmacopoeia defines acceptable limits of particle contamination for intravenous solutions. Used conventionally, these solutions are filtered by the lungs, and there are few reports of particle-induced tissue injury to the systemic circulation. We have used an isolated rat heart model to assess whether unfiltered direct intraarterial administration of cardioplegic solutions, as in open-heart surgery, can be damaging to the myocardium. An intravenous solution of U.S. commercial manufacture was selected for evaluation. Particle-counting revealed this solution to be well within the U.S.P. limits. Direct intracoronary infusion of this solution at 20 degrees C and at constant pressure led to an approximate 75% reduction in coronary flow over 20 min. Filtration through a membrane of 0.8-micron porosity largely prevented this reduction of coronary flow. In studies with multidose cardioplegia (3-min infusions every 30 min), hearts given filtered solution recovered almost 90% of their preischemic functional capacity after 3 hr of hypothermic (20 degrees C) ischemic arrest. Hearts given an identical unfiltered solution essentially failed to recover despite the particle counts having conformed to the U.S.P. limit. This functional result was supported by measurement of creatine kinase leakage, which was significantly higher in the unfiltered group. These studies provide an argument for revision of U.S.P. particle limits when applied to intraarterially administered solutions; in particular, we believe that equipment for cardioplegic infusion into coronary arteries should incorporate a 0.8-micron in-line filter.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"503-12"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15103992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for prostaglandins in reperfusion-induced myocardial injury? 前列腺素在再灌注心肌损伤中的作用?

Advances in myocardiology Pub Date : 1985-01-01

M Karmazyn

引用次数: 0