Advances in myocardiology最新文献_第2页

Reduction of myocardial infarct size in rats under the effect of bepridil. 贝必地尔对大鼠心肌梗死面积的影响。

Advances in myocardiology Pub Date : 1985-01-01 DOI: 10.1016/0022-2828(83)90876-3

V. Richard, J. de Leiris

引用次数: 7

Quantitation of cardiac messenger RNA in heart-muscle biopsies. 心肌活组织检查中心脏信使RNA的定量。

Advances in myocardiology Pub Date : 1985-01-01

J Zähringer, N Pritzl, G Stäb, E Kreuzer

引用次数: 0

The calmodulin-dependent phosphorylation of cardiac myosin. 心肌肌球蛋白的钙调素依赖性磷酸化。

Advances in myocardiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4757-1287-2_6

F Hofmann, M Zimmer

引用次数: 0

In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia. 心脏缺血时局部代谢反应的体内磷-31核磁共振研究。

Advances in myocardiology Pub Date : 1985-01-01

C R Malloy, P M Matthews, M B Smith, G K Radda

引用次数: 0

Accelerated recovery of ischemic canine myocardium induced by AMP. Preliminary report. AMP对犬缺血心肌加速恢复的初步报道。

Advances in myocardiology Pub Date : 1985-01-01

H M Sami, J R Koke, N Bittar

引用次数: 0

The adrenochrome pathway. A potential catabolic route for adrenaline metabolism in inflammatory disease. 肾上腺素色素途径。炎症性疾病中肾上腺素代谢的潜在分解代谢途径。

Advances in myocardiology Pub Date : 1985-01-01

S B Matthews, M B Hallett, A H Henderson, A K Campbell

{"title":"The adrenochrome pathway. A potential catabolic route for adrenaline metabolism in inflammatory disease.","authors":"S B Matthews, M B Hallett, A H Henderson, A K Campbell","doi":"","DOIUrl":"","url":null,"abstract":"Polymorphonuclear leukocytes activated by latex (polystyrene) beads or the chemotactic peptide N-formyl Met Leu Phe stimulated the oxidation of adrenaline (0.3 microM-10 mM) to adrenochrome, detected spectrophotometrically at 480 nm or by a high-performance liquid chromatographic (HPLC) method. This oxidation was detectable within 5 min and continued for at least 4 hr. Over the concentration range 0.3-10 microM, more than 80% of the adrenaline oxidation occurred via the adrenochrome pathway rather than the amine oxidase-catechol methyltransferase pathway. Medium isolated after stimulation of the polymorphonuclear leukocytes retained the ability to oxidize adrenaline to adrenochrome. Serum from patients after myocardial infarction induced more oxidation of adrenaline to adrenochrome than control serum. Superoxide dismutase, catalase, and azide inhibited by 70-95% the oxidation of adrenaline to adrenochrome, either by cells or medium. Commercially available adrenochrome was biologically active, but some of the actions were due to contaminants of the preparation. HPLC of an extract of synovial fluid from a patient with rheumatoid arthritis, a fluid that contains polymorphonuclear leukocytes, showed a peak identical to that of the adrenochrome standard. The results provide a cellular mechanism for adrenochrome formation and preliminary evidence that adrenochrome can be produced in inflammatory conditions in which polymorphonuclear leukocyte infiltration occurs.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"367-81"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15106645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-time-resolution 31P NMR studies of the perfused ferret heart. 灌注雪貂心脏的高时间分辨率31P核磁共振研究。

Advances in myocardiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4757-1287-2_3

P G Morris, D G Allen, C H Orchard

{"title":"High-time-resolution 31P NMR studies of the perfused ferret heart.","authors":"P G Morris, D G Allen, C H Orchard","doi":"10.1007/978-1-4757-1287-2_3","DOIUrl":"https://doi.org/10.1007/978-1-4757-1287-2_3","url":null,"abstract":"A cell is described that has enabled isolated Langendorff-perfused ferret hearts to be studied in a Bruker WM200 widebore superconducting nuclear magnetic resonance (NMR) spectrometer. Left ventricular pressure was monitored with a latex balloon catheter, and the hearts were paced with a stimulator triggered from the spectrometer's central computer, enabling gated studies to be performed. Suitable radiofrequency filtering for the pacing leads is described. Phosphorus (31P) NMR was used to determine internal pH and the concentration of phosphorylated metabolites under resting conditions. The perfusion rate is shown to affect the phosphocreatine/ATP ratio at low flow rates, but the removal of phosphate from the perfusate is shown not to affect metabolite levels or the internal pH. The time resolution of the method is assessed and its potential for monitoring transient effects illustrated by studies of the effects of acetylcholine and cyanide-induced anoxia. The cardiac gated 31P NMR experiment is discussed and four spectra, corresponding to mid- and end systole and mid- and end diastolic are presented. No effects of cycling of high-energy phosphates are evident in these results.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"5 ","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15082603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Role of the cholinergic system in the modulation of ventricular arrhythmias induced by subepicardial epinephrine in the dog. 胆碱能系统在狗心包下肾上腺素诱发室性心律失常的调节中的作用。

Advances in myocardiology Pub Date : 1985-01-01

P K Das, T K Bhattacharya, S S Gambhir

{"title":"Role of the cholinergic system in the modulation of ventricular arrhythmias induced by subepicardial epinephrine in the dog.","authors":"P K Das, T K Bhattacharya, S S Gambhir","doi":"","DOIUrl":"","url":null,"abstract":"The modulating role of the cholinergic system in epinephrine (EP)-induced ventricular arrhythmias (VAs) was studied in anesthetized (alpha-chloralose and pentobarbitone sodium) dogs. Unifocal VAs were produced by subepicardial infusion of EP (4 X 10(-3)M) in 2.5 X 10(-3) M CaCl2-0.9% NaCl at a rate of 10 microliter/min for a maximum period of 10 min at a time. One of the interacting drugs acetylcholine Cl (ACh), carbachol Cl (CCh), physostigmine salicylate (PHY), DL-propranolol HC1 (PROP), quindine HC1 (QD), lidocaine HC1 (LD), and atropine sulfate (AT) was given in an equimolar concentration (4 X 10(-3)M) along with EP. The effects of bilateral vagotomy (VT) were also studied. The time of onset, frequency, and duration of VAs were recorded. Reproducible cognizable VAs (less than 10%) were produced by EP in 38 of 43 experimental dogs. Focal infusion of the cholinomimetic agent ACh or CCh marketedly inhibited the arrhythmogenic activity of EP at the focal site. The effect of the anticholinesterase agent PHY was similar. These experiments showed that exogenous administration of a cholinomimetic agent or focal facilitation of endogenous cholinergic influence had an antiarrhythmic activity against EP. On the other hand, bilateral VT or focal infusion of AT markedly potentiated the arrhythmogenic potentiality of EP. Thus, it appeared that removal of endogenous influence facilitated EP-induced arrhythmias. The antiarrhythmic activities of the beta-adrenoceptor-blocking agent PROP and the membrane-stabilizing agents LD and QD against EP were confirmed using the subepicardial infusion technique. These studies show that the presence of cardiovagal tone or its facilitation inhibits, and its blockade increases, the propensity to VAs in situations in which the adrenergic system may be involved primarily or otherwise. The receptors involved appear to be muscarinic in nature.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"349-65"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13723998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differing potencies and dose-response characteristics in the ability of slow-calcium-channel blockers to reduce enzyme leakage in the calcium paradox. 在钙悖论中，慢钙通道阻滞剂减少酶泄漏能力的不同效价和剂量反应特征。

Advances in myocardiology Pub Date : 1985-01-01

J E Baker, D J Hearse

{"title":"Differing potencies and dose-response characteristics in the ability of slow-calcium-channel blockers to reduce enzyme leakage in the calcium paradox.","authors":"J E Baker, D J Hearse","doi":"","DOIUrl":"","url":null,"abstract":"In studies of the calcium paradox, we have used an isolated rat heart preparation to investigate the relationship between myocardial creatine kinase leakage and the concentration of slow-calcium-channel blockers (nifedipine or verapamil) in the perfusion fluid during a cycle of calcium reduction and repletion. The results indicated that enzyme leakage could be further reduced to a degree greater than that seen under conditions of a full calcium paradox (complete calcium depletion). Detailed dose-response studies with verapamil and nifedipine at a calcium concentration of 1.0 mM during a 20-min period of calcium repletion following a 10-min period of calcium reduction (12 microM calcium) revealed complex dose-response characteristics for each drug. In the dose range studied (0-20 microM), nifedipine was able to reduce enzyme leakage maximally by 57 +/- 8% and verapamil by 37 +/- 4%. Optimal concentrations for verapamil and nifedipine were 4.0 and 2.0 microM, respectively. Both drugs exhibited bell-shaped dose-response curves without a loss of efficacy at higher concentrations. There was no resumption in contractile activity in the drug-treated groups. Simultaneous use of verapamil and nifedipine at their optimal concentrations failed to improve the reduction in enzyme leakage to a reduction greater than that observed with one drug alone.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"637-46"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13724542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary hyperemia and cardiac hypertrophy following inhibition of fatty acid oxidation. Evidence of a regulatory role for cytosolic phosphorylation potential. 抑制脂肪酸氧化后的冠状动脉充血和心脏肥厚。细胞质磷酸化电位调控作用的证据。

Advances in myocardiology Pub Date : 1985-01-01

A J Higgins, J M Faccini, P Greaves

{"title":"Coronary hyperemia and cardiac hypertrophy following inhibition of fatty acid oxidation. Evidence of a regulatory role for cytosolic phosphorylation potential.","authors":"A J Higgins, J M Faccini, P Greaves","doi":"","DOIUrl":"","url":null,"abstract":"Oxfenicine (S-4-hydroxyphenylglycine) is a cardioselective inhibitor of long-chain fatty acid oxidation. In anesthetized dogs, oxfenicine (3.3 mg/kg, i.v.) increased myocardial blood flow by 33% under normal conditions and by 71% during isoprenaline infusion, but produced no other hemodynamic changes. Similar results were obtained with two other inhibitors of fatty acid oxidation, 2-bromopalmitate and 2-tetradecylglycidate. Chronic administration of oxfenicine to dogs for 1 year produced dose-related, nonpathological increases in relative heart weight (up to 85% at 750 mg/kg per day). Smaller effects (up to 30% at 900 mg/kg per day) were observed in a similar study in rats. Cardiac hypertrophy has previously been reported in rodents treated with 2-tetradecylglycidate. Moreover, cardiomegaly is frequently observed in cases of carnitine deficiency. We therefore suggest that coronary hyperemia and cardiac hypertrophy following either inhibition of fatty acid oxidation or an increase in cardiac work load may be adaptive changes triggered by a common mechanism-namely, a fall in cytosolic phosphorylation potential. In support of this, oxfenicine decreased the phosphocreatine/creatine ratio in rat hearts perfused in the presence of oleate. These findings suggest the possibility that metabolic abnormalities may provide the key to many idiopathic cardiomyopathies of uncertain origin.","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":"6 ","pages":"329-38"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14289250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0