{"title":"Specificity and use of antisera produced against anticancer drugs.","authors":"K Fujiwara, T Kitagawa","doi":"10.1007/978-1-4613-9558-4_6","DOIUrl":"https://doi.org/10.1007/978-1-4613-9558-4_6","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"2 ","pages":"251-92"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14448360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abnormality in immunoregulatory cells in human malignancies.","authors":"S Gupta","doi":"10.1007/978-1-4613-9558-4_2","DOIUrl":"https://doi.org/10.1007/978-1-4613-9558-4_2","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"2 ","pages":"131-53"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14096639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Platelet and granulocyte transfusions in cancer patients.","authors":"J P Dutcher","doi":"10.1007/978-1-4613-9558-4_5","DOIUrl":"https://doi.org/10.1007/978-1-4613-9558-4_5","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"2 ","pages":"211-49"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14448359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic and pathogenetic implications of immune complexes in human cancer.","authors":"F A Salinas, K H Wee","doi":"10.1007/978-1-4613-9558-4_4","DOIUrl":"https://doi.org/10.1007/978-1-4613-9558-4_4","url":null,"abstract":"<p><p>The dynamic relationships of circulating immune complexes (CIC) and associated immune reactants to stage of disease and prognosis in cancer patients have been evaluated for malignant melanoma. Patients were divided into group I patients, with no evidence of disease at sample time; group II patients, with minimal tumor burden; and group III patients, with advanced metastatic disease. By means of single- and serial-sample determinations, we have demonstrated correlation of CIC concentration, size, and composition to tumor burden, disease progression, and high risk of disease recurrence. In view of the phenotypic heterogeneity of antigen expression in malignant melanoma, we have extracted, purified, and utilized melanoma-associated antigens (MAA) from CIC, and human oncofetal antigens (HOFA) from fetal liver cells, and reacted them with patients' sera in an in vitro model that simulates tumor burden changes. The observed changes in CIC concentration and lattice size upon reaction with MAA and HOFA demonstrated a significant (p less than or equal to 0.001) relationship to patients' in vivo tumor burden, as well as to the origin of serum and antigen involved. Our results suggest a homeostasis of CIC size and concentration to associated antibodies and antigens operational in malignant melanoma patients' sera. In addition, we have demonstrated how the monitoring of more than one immune reactant, characterization of CIC size and composition, and evaluation of resulting reequilibrium caused by in vitro addition of antigen or antibody, could allow for an improved assessment of humoral immunity and its related pathogenetic effects in cancer patients.</p>","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"2 ","pages":"189-209"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14096640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suppressor cells and malignancy. I. Suppressor macrophages and suppressor T cells in experimental animals.","authors":"D Naor, J S Duke-Cohan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"2 ","pages":"1-129"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14096638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumor growth versus fetal development--similarities and confusions.","authors":"P. Ray, S. Saha","doi":"10.1007/978-1-4613-9558-4_3","DOIUrl":"https://doi.org/10.1007/978-1-4613-9558-4_3","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"8 7","pages":"155-87"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50973826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumor growth versus fetal development--similarities and confusions.","authors":"P K Ray, S Saha","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"2 ","pages":"155-87"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14448358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Active specific immunotherapy as an adjunct to the treatment of metastatic solid tumors: present and future prospects.","authors":"M E Key, H C Hoover, M G Hanna","doi":"10.1007/978-1-4612-5068-5_6","DOIUrl":"https://doi.org/10.1007/978-1-4612-5068-5_6","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"1 ","pages":"195-219"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15029493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunity and its role in conventional cancer therapy.","authors":"P K Ray, M Seshadri, T B Poduval","doi":"10.1007/978-1-4612-5068-5_2","DOIUrl":"https://doi.org/10.1007/978-1-4612-5068-5_2","url":null,"abstract":"","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"1 ","pages":"29-95"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4612-5068-5_2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15029494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complement and cancer: activation of the alternative pathway as a theoretical base for immunotherapy.","authors":"P D Cooper","doi":"10.1007/978-1-4612-5068-5_4","DOIUrl":"https://doi.org/10.1007/978-1-4612-5068-5_4","url":null,"abstract":"<p><p>Activation of the APC is pointed out as the common factor in all sufficiently studied cancer treatments employing nonspecific, active immunotherapy. This chapter outlines the molecular biology of both APC and classical pathway of complement, summarizes the alternative pathway's biologic activities especially in relation to the C3/C5 convertase C3b,Bb, and its implications in the mechanism of host defense against malignancies, particularly relating to the activated macrophage. The many involvements of the APC in the various agents used for nonspecific active immunotherapy are reviewed, and possible clinical implications outlined. It is concluded that activation of the APC can be proposed as the specific theoretical basis so far lacking for this treatment modality and that it is accordingly feasible to attempt to monitor clinical application of this principle by fine-tuning of APC activation in cases of human cancer.</p>","PeriodicalId":77830,"journal":{"name":"Advances in immunity and cancer therapy","volume":"1 ","pages":"125-66"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15029491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}