Advances in cyclic nucleotide and protein phosphorylation research最新文献

Early events in insulin actions. 胰岛素作用的早期事件。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1986-01-01

R M Denton

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Cyclic AMP and learning in Drosophila. 果蝇的环AMP与学习。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1986-01-01

Y Dudai

引用次数: 0

Forskolin: its biological and chemical properties. 福斯克林:它的生物和化学性质。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1986-01-01

K B Seamon, J W Daly

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Desensitization of hormonal stimuli coupled to regulation of cyclic AMP levels. 激素刺激的脱敏与循环AMP水平的调节耦合。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1986-01-01

R B Clark

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Mechanisms involved in calcium-mobilizing agonist responses. 参与钙动员激动剂反应的机制。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1986-01-01

J H Exton

{"title":"Mechanisms involved in calcium-mobilizing agonist responses.","authors":"J H Exton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Many hormones and neurotransmitters exert their biological effects by increasing the levels of Ca2+ and 1,2-diacylglycerol in their target cells. Major agonists that act in this way are epinephrine and norepinephrine, acetylcholine, vasopressin, cholecystokinin, and angiotensin II. These and other Ca2+-mobilizing agonists may also produce effects that are not mediated by Ca2+ or diacylglycerol, but involve separate receptors and an increase or decrease in cyclic AMP. The general mechanisms by which Ca2+-mobilizing agonists induce their physiological responses are depicted in Fig. 12. These responses appear to involve an initial mobilization of Ca2+ from endoplasmic reticulum and perhaps other intracellular Ca2+ stores, followed by alterations in the flux of Ca2+ across the plasma membrane. The Ca2+ changes are consistently associated with increased turnover of cellular phosphoinositides. The most rapid response is breakdown of phosphatidylinositol 4,5-P2 in the plasma membrane, and there is much evidence that this involves a guanine-nucleotide-binding regulatory protein similar to those involved in the regulation of adenylate cyclase. Myo-inositol 1,4,5-P3 produced by phosphatidylinositol 4,5-P2 breakdown rapidly releases Ca2+ from endoplasmic reticulum, and it is likely that it is the long-sought second message for the Ca2+-dependent hormones. 1,2-Diacylglycerol, the other product of phosphatidylinositol 4,5-P2 breakdown, also acts as a second message in that it activates protein kinase C, a Ca2+-phospholipid-dependent protein kinase, by lowering its requirement for Ca2+. The cellular substrates for protein kinase C and its role in the different physiological responses to the Ca2+-mediated agonists are currently being defined. The major intracellular target for Ca2+ is the Ca2+-dependent regulatory protein calmodulin. This binds Ca2+ with high affinity, and the resulting complex interacts with a variety of enzymes and other cellular proteins, modifying their activities. A major target is the multifunctional calmodulin-dependent protein kinase that phosphorylates and alters the activities of many proteins, for example, glycogen synthase and tyrosine hydroxylase. Calcium ions may also stimulate calmodulin-dependent protein kinases that are more specific, such as phosphorylase kinase and myosin light-chain kinase. Other important Ca2+-calmodulin targets are the microtubule-associated proteins, but it is likely that many more will be found.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":77829,"journal":{"name":"Advances in cyclic nucleotide and protein phosphorylation research","volume":"20 ","pages":"211-62"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14160999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Choline plasmalogens, glycerophospholipid methylation, and receptor-mediated activation of adenylate cyclase. 胆碱缩醛原，甘油磷脂甲基化和受体介导的腺苷酸环化酶激活。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1986-01-01

L A Horrocks, Y K Yeo, H W Harder, R Mozzi, G Goracci

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Properties of human erythrocyte Ns and Ni, the regulatory components of adenylate cyclase, as purified without regulatory ligands. 在没有调节配体的情况下纯化的人红细胞腺苷酸环化酶的调节组分n和Ni的性质。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1985-01-01

J D Hildebrandt, J Codina, W Rosenthal, T Sunyer, R Iyengar, L Birnbaumer

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Regulation of alpha 2 adrenoceptors by nucleotides, ions, and agonists: comparison in cells of neural and nonneural origin. 核苷酸、离子和激动剂对α 2肾上腺素受体的调节:神经和非神经来源细胞的比较。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1985-01-01

J C Mitrius, D C U'Prichard

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Lipolysis and cyclic-AMP-dependent protein kinase in adipocytes: adenylate cyclase regulators versus insulin. 脂肪细胞中的脂肪分解和环amp依赖性蛋白激酶:腺苷酸环化酶调节剂与胰岛素。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1985-01-01

C Londos, R C Honnor, G S Dhillon, D L Johnson

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Somatostatin inhibition of cyclic AMP accumulation and adrenocorticotropin release from mouse anterior pituitary tumor cells: mode of action and self-regulation. 生长抑素抑制小鼠垂体前叶肿瘤细胞环AMP积累和促肾上腺皮质激素释放:作用模式和自我调节。

Advances in cyclic nucleotide and protein phosphorylation research Pub Date : 1985-01-01

T D Reisine

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