Survey and synthesis of pathology research最新文献

{"title":"The role of calcium in cell injury and repair: a hypothesis.","authors":"B F Trump, I K Berezesky","doi":"10.1159/000156978","DOIUrl":"https://doi.org/10.1159/000156978","url":null,"abstract":"","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 3","pages":"248-56"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14140912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical induction of tumor cell differentiation.","authors":"R M Niles","doi":"10.1159/000156981","DOIUrl":"https://doi.org/10.1159/000156981","url":null,"abstract":"","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 4","pages":"282-95"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14148325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparameter analysis of human lymphocyte subpopulations using flow cytometry.","authors":"D E Lewis,&nbsp;K S Barron,&nbsp;G P Miller,&nbsp;R R Rich","doi":"10.1159/000156977","DOIUrl":"https://doi.org/10.1159/000156977","url":null,"abstract":"<p><p>This review has emphasized several recent advances in our understanding of human lymphocyte biology made possible by mAbs that recognize specific functional subpopulations of lymphocytes, coupled with multiparameter flow-cytometric analysis. In the last 3 years, both the T4+ and T8+ subsets of T cells have been further divided according to function and appearance of specific cell surface antigens. In addition, subpopulations of NK cells with different maturation states and B cells with distinct functional abilities have been discovered. Multiparameter flow-cytometric analysis of lymphocyte subpopulations can provide clues to the pathogenetic mechanisms of immune disorders, as has been demonstrated in AIDS patients and children with JRA. The use of multiparameter flow-cytometric analysis to study human immune responses in vitro has enabled a clearer understanding of the complex lymphoid interactions and, as we believe, may play an important role in the analysis of immune-associated disease processes.</p>","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 3","pages":"237-47"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14072884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous bone marrow transplantation in acute leukemia.","authors":"K A Dicke,&nbsp;L Vellekoop,&nbsp;A Zander,&nbsp;S Jagannath,&nbsp;C Poynton,&nbsp;B Lichtiger,&nbsp;D S Verma,&nbsp;G Spitzer","doi":"10.1159/000156967","DOIUrl":"https://doi.org/10.1159/000156967","url":null,"abstract":"","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 1","pages":"84-96"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunology of viral diabetes.","authors":"P G Babu,&nbsp;S A Huber,&nbsp;J E Craighead","doi":"10.1159/000156960","DOIUrl":"https://doi.org/10.1159/000156960","url":null,"abstract":"","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14125767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of cell-mediated cytolysis by natural killer cells.","authors":"G Dennert","doi":"10.1159/000156966","DOIUrl":"https://doi.org/10.1159/000156966","url":null,"abstract":"","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 1","pages":"69-83"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.","authors":"G Klöppel,&nbsp;M Löhr,&nbsp;K Habich,&nbsp;M Oberholzer,&nbsp;P U Heitz","doi":"10.1159/000156969","DOIUrl":"https://doi.org/10.1159/000156969","url":null,"abstract":"<p><p>The present review draws attention to the diversity of islet lesions seen in human type 1 and type 2 diabetes. This heterogeneity of islet changes is best demonstrated by immunocytochemistry. In type 1 diabetes the endocrine pancreas is characterized by selective loss of B cells, which most likely results from a slowly acting autoimmune process depending on the presence of both genetic and environmental factors. The process starts years before overt diabetes develops and manifests when the B-cell volume is reduced by about 80%. In type 2 diabetes B cells are always present, regardless of the duration and severity of the disease, but lack any signs of functional activity. This reflects a secretory defect of the B cells which obviously becomes evident under the conditions of obesity, hyperinsulinism and insulin resistance. Obese but non-diabetic subjects show, in parallel to their hyperinsulinism, an increased B cell volume, suggesting that under prediabetic conditions the B cells have still the capacity to respond to increased functional demands by enhanced proliferation. In manifest diabetes the B cells have lost their proliferative potential. Whether this is due to an inherent defect or the consequence of a functional disturbance, is not clear. The development of islet amyloidosis most likely represents an associated functional abnormality of the B cell.</p>","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 2","pages":"110-25"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15015386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective mechanisms of experimental vaccine-induced immunity to Pseudomonas aeruginosa.","authors":"M M Lieberman","doi":"10.1159/000156983","DOIUrl":"https://doi.org/10.1159/000156983","url":null,"abstract":"","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 4","pages":"312-22"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15054786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercury-induced autoimmune glomerulonephritis in inbred rats. II. Immunohistopathology, histopathology and effects of prostaglandin administration.","authors":"P Hirszel,&nbsp;J H Michaelson,&nbsp;K Dodge,&nbsp;H Yamase,&nbsp;P E Bigazzi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The repeated administration of mercuric chloride to BN rats induces the production of anti-GBM. In the present paper, we describe the immunohistopathology and histopathology of the kidneys from mercuricchloride-treated rats. Direct immunofluorescence demonstrated bright linear deposits of immunoglobulins at the level of the GBM of the kidney. Light microscopy failed to reveal substantial glomerular changes, but electron microscopy demonstrated a spectrum of ultrastructural alterations of the glomeruli (including the detachment of endothelial cells from the GBM and the presence of electron-opaque deposits). In the aggregate, these findings are suggestive of membranous glomerulonephritis. We also investigated whether treatment with low doses of PG had any effect on the course of this experimental model of autoimmune renal disease. Two groups of mercuric-chloride-treated BN rats received different doses of DMPGE2. This resulted in significantly lower levels of circulating autoantibodies to the GBM, as well as a decrease in the amounts of rat immunoglobulins bound to the kidneys and an increase in proteinuria. On the other hand, there were no major differences in renal histopathology between rats treated with DMPGE2 and controls.</p>","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 5-6","pages":"412-22"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15028472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute phase response in infectious disease.","authors":"J Gauldie,&nbsp;L Lamontagne,&nbsp;A Stadnyk","doi":"10.1159/000156970","DOIUrl":"https://doi.org/10.1159/000156970","url":null,"abstract":"<p><p>In considering the pathology associated with infectious diseases, the most common host response to such infection is inflammation. The mechanism(s) whereby inflammation is initiated and the cell types involved will dictate the kinds of acute phase plasma changes that can be seen associated with the infection. Bacteria seem to initiate the classical type of inflammatory response and plasma protein changes similar to those seen in experimental inflammation induced by chemical means. Viruses, on the other hand, in the absence of cytopathology do not appear to induce the same kind of inflammatory changes and avoid the induction of the acute phase protein response since they may not initiate activation of monocytes and/or macrophages. Those viruses that do cause macrophage activation would be expected to have acute phase protein changes associated with that activation. Parasites, however, appear to initiate the acute phase plasma response only when their migration leads to tissue destruction and local inflammation such as caused by parasitemia with Trypanosoma cruzi in the mouse or with migration of Nippostrongylus brasiliensis in the rodent. Human parasitic diseases require much more investigation in order to clarify the role played by acute phase proteins in the subsequent establishment of the host-parasite relationship. We postulate that the macrophage or monocyte on interaction with the infectious pathogen becomes activated and secretes a number of factors, including interleukin 1 and hepatocyte-stimulating factor, which have a marked effect on the total acute phase reaction. In addition to an effect on phagocytic and immune systems, the mediators cause hepatocytes to markedly increase the secretion of plasma acute phase proteins. Some of these proteins return to the site of inflammation and interact with the infectious pathogen and/or cells and proteins of the host, thereby affecting the final outcome of inflammation. We also propose that the initial interaction of an organism such as a parasite and the mammalian host involves early recognition by the macrophage, thereby initiating both the humoral and cellular acute phase reactions and subsequently affects the immune response against the parasite. Variations in the acute phase reaction may help to explain differences in susceptibility to infectious organisms and the presence or lack of host killing mechanisms for the parasite.</p>","PeriodicalId":77803,"journal":{"name":"Survey and synthesis of pathology research","volume":"4 2","pages":"126-51"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000156970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13560610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}