Reviews in clinical & basic pharmacology最新文献

Digitalis glycosides: a discussion of the similarities and differences in actions and existing controversies. 洋地黄苷类:作用的异同及存在争议的讨论。

Reviews in clinical & basic pharmacology Pub Date : 1988-01-01 DOI: 10.1515/jbcpp.1988.7.1-4.1

C M Lathers, L J Lipka, H Klions

{"title":"Digitalis glycosides: a discussion of the similarities and differences in actions and existing controversies.","authors":"C M Lathers, L J Lipka, H Klions","doi":"10.1515/jbcpp.1988.7.1-4.1","DOIUrl":"https://doi.org/10.1515/jbcpp.1988.7.1-4.1","url":null,"abstract":"The writing of this review was initiated to answer the question of whether differences in the actions of the various digitalis glycosides exist and to discuss current controversies in the research area of the digitalis glycosides. Data obtained in our laboratory indicated that the effect of digoxin on postganglionic cardiac sympathetic neural discharge in the minute prior to the occurrence of arrhythmia differed from that of ouabain. This raised the question of whether data published in other laboratories would support the contention that differences in glycosides do exist. To answer this question, a review of the literature was begun. Our survey of these studies are cited in the tables of this review. These tables summarize the actions of glycosides in vivo and in vitro in different animal models. The reader should bear in mind that the data included within the tables do not represent an inclusive summary of all studies in the literature. For detailed review articles, the reader is referred to the following references: Gillis et al; Gillis and Quest; Roberts et al; Lathers and Roberts; Farah and Alousi; Benthe; Levitt et al; Smith and Haber; Somberg; Lee and Klaus; Mason; Schwartz. Furthermore the summary of the results for each particular study cited in the table may not, in all cases, include each finding of the published data. Nevertheless, the tables do provide a summary of data obtained in various species with different glycosides in several different areas of research, and as such, represent an abridged compendium for the research working in the field of digitalis glycosides. This review has been organized firstly to consider glycoside-induced alterations in the autonomic nervous system and, secondly, to examine their direct actions on the heart.","PeriodicalId":77781,"journal":{"name":"Reviews in clinical & basic pharmacology","volume":"7 1-4","pages":"1-108"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jbcpp.1988.7.1-4.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14205015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Role of cyclic GMP in the modulation by endothelium of the adrenolytic action of prazosin in the rat isolated aorta. 环GMP在内皮细胞调节大鼠离体主动脉哌唑嗪的溶肾上腺作用中的作用。

Reviews in clinical & basic pharmacology Pub Date : 1988-01-01

F V DeFeudis

{"title":"Role of cyclic GMP in the modulation by endothelium of the adrenolytic action of prazosin in the rat isolated aorta.","authors":"F V DeFeudis","doi":"","DOIUrl":"","url":null,"abstract":"Taking their lead from studies which have shown that endothelium-derived relaxing factor(s) (EDRF) mediates vasorelaxation by activating smooth muscle guanyl cyclase, the authors of the current article have examined the role of the endothelium in relation to the effects of the alpha-adrenoceptor antagonist prazosin. Prazosin acted as a non-competitive antagonist of norepinephrine- (NE-) induced contraction in rat aortic preparations with intact endothelium, but as a competitive antagonist in endothelium-denuded preparations. The affinity of NE for its smooth muscle receptor was the same in the presence or absence of endothelium, but its efficacy was 7 times lower in the presence than in the absence of endothelium. Other experiments showed that inhibition of guanyl cyclase by methylene blue in the presence of endothelium (like endothelium removal) led to competitive antagonism of NE responses by prazosin, and that increasing the tissue content of cyclic GMP by pre-incubating de-endothelialized preparations with 8-Br-cyclic GMP (as in intact preparations) led to non-competitive antagonism of NE responses by prazosin. The authors concluded that EDRF, by increasing the cyclic GMP content of vascular smooth muscle of rat aorta, can modify the efficacy of NE, and thereby alter the mode of antagonism of prazosin.","PeriodicalId":77781,"journal":{"name":"Reviews in clinical & basic pharmacology","volume":"7 1-4","pages":"209-10"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13992628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pharmacology of peripheral alpha 1- and alpha 2-adrenoceptors. 外周α 1-和α 2-肾上腺素受体的药理学。

Reviews in clinical & basic pharmacology Pub Date : 1988-01-01

A J Nichols, J P Hieble, R R Ruffolo

引用次数: 0

Opioid antagonist-induced upregulation and functional supersensitivity. 阿片拮抗剂诱导的上调和功能超敏感。

Reviews in clinical & basic pharmacology Pub Date : 1988-01-01 DOI: 10.1515/jbcpp.1988.7.1-4.109

B C Yoburn

引用次数: 5

Inhibition of monoamine oxidase by 3,4-dihydroxyphenyl 1-alanine and its analogs. 3,4-二羟基苯基丙氨酸及其类似物对单胺氧化酶的抑制作用。

Reviews in clinical & basic pharmacology Pub Date : 1988-01-01

F V DeFeudis

引用次数: 0

Membrane effects of ethanol in excitable cells. 乙醇在可兴奋细胞中的膜效应。

Reviews in clinical & basic pharmacology Pub Date : 1987-07-01 DOI: 10.1515/jbcpp.1987.6.3.213

A C Swann

{"title":"Membrane effects of ethanol in excitable cells.","authors":"A C Swann","doi":"10.1515/jbcpp.1987.6.3.213","DOIUrl":"https://doi.org/10.1515/jbcpp.1987.6.3.213","url":null,"abstract":"Ethanol has a wide range of biochemical and behavioral effects. Many of these can be explained by the ability of ethanol to reduce the amount of order, or increase the fluidity, in biological membranes. During chronic ethanol administration, membrane fluidity in the absence of ethanol and the sensitivity of membrane fluidity to added ethanol are decreased. Changes in membrane lipid composition that are consistent with decreased fluidity or with resistance to ethanol including increases in membrane cholesterol, reductions in the double bond index of phospholipid acyl chains, and increases in anionic phospholipids, have been reported during ethanol treatment. These changes are not found uniformly, however, and membrane tolerance and resistance have been reported in their absence. A variety of changes in lipid metabolism have been reported; their possible relevance to these adaptive changes is discussed. Ethanol treatment affects several transport systems in membranes; Na+, K+-ATPase, Ca++-ATPase, and other Ca++ transport systems all appear to undergo adaptive changes during ethanol treatment. Alterations in these systems may account for some of the effects of ethanol on activity-dependent energy metabolism and neurotransmitter release. Paradoxes in the membrane actions of ethanol remain to be resolved, including the weakness of membrane fluidization by ethanol in vitro compared to the evidence that it occurs in vivo, and the consistency with which adaptive changes in membrane fluidity and in Na+, K+-ATPase are observed compared to the inconsistency in changes in membrane composition.","PeriodicalId":77781,"journal":{"name":"Reviews in clinical & basic pharmacology","volume":"6 3","pages":"213-48"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jbcpp.1987.6.3.213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14436748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Abstracts. 1987 annual meeting of the Israeli Physiological and Pharmacological Society. 摘要:1987年以色列生理与药理学会年会。

Reviews in clinical & basic pharmacology Pub Date : 1987-07-01

引用次数: 0

Synaptic pharmacology of the hippocampus. 海马突触药理学。

Reviews in clinical & basic pharmacology Pub Date : 1987-07-01 DOI: 10.1515/jbcpp.1987.6.3.189

R Pohorecki, E F Domino

引用次数: 3

Adenylate cyclase in senescence: catecholamine and parathyroid hormone pathways. 衰老中的腺苷酸环化酶:儿茶酚胺和甲状旁腺激素途径。

Reviews in clinical & basic pharmacology Pub Date : 1987-04-01 DOI: 10.1515/jbcpp.1987.6.2.105

P J Scarpace, H J Armbrecht

引用次数: 10