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Autolymphocyte therapy: previous experience and future prospects. 自体淋巴细胞治疗:以往经验与未来展望。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157077
M E Osband, R J Krane
{"title":"Autolymphocyte therapy: previous experience and future prospects.","authors":"M E Osband,&nbsp;R J Krane","doi":"10.1159/000157077","DOIUrl":"https://doi.org/10.1159/000157077","url":null,"abstract":"<p><p>Autolymphocyte therapy is outpatient medical treatment for selected patients, in which a relatively small amount of white blood cells is removed temporarily from the patients, modified in the laboratory through sophisticated biotechnology, and returned to the patient for the purpose of enhancing the immune system and contributing to improved health. We suggest that autolymphocyte therapy might be a useful approach in the prevention or treatment of several diseases. Previous work with autolymphocyte therapy in the treatment of metastatic renal cell carcinoma has demonstrated that this approach is minimally toxic and biologically active. Further clinical trials are justified and currently taking place.</p>","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 6","pages":"483-93"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14393386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Contents, Vol. 7, 1988 目录，第7卷，1988年
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157071
S. Nasr, H. Sabio, E. Ades, M. Osband, R. Krane, R. Kradin, R. Yamin, J. Kurnick, Jeffrey W. Clark, D. Longo, J. Mier, F. Aronson, R. Numerof, G. Vachino, M. Atkins, R. Kradin
{"title":"Contents, Vol. 7, 1988","authors":"S. Nasr, H. Sabio, E. Ades, M. Osband, R. Krane, R. Kradin, R. Yamin, J. Kurnick, Jeffrey W. Clark, D. Longo, J. Mier, F. Aronson, R. Numerof, G. Vachino, M. Atkins, R. Kradin","doi":"10.1159/000157071","DOIUrl":"https://doi.org/10.1159/000157071","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64938829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subject Index, Vol. 7, 1988 主题索引，1988年第7卷
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157079
S. Nasr, H. Sabio, E. Ades, M. Osband, R. Krane, R. Kradin, R. Yamin, J. Kurnick, Jeffrey W. Clark, D. Longo, J. Mier, F. Aronson, R. Numerof, G. Vachino, M. Atkins, R. Kradin
{"title":"Subject Index, Vol. 7, 1988","authors":"S. Nasr, H. Sabio, E. Ades, M. Osband, R. Krane, R. Kradin, R. Yamin, J. Kurnick, Jeffrey W. Clark, D. Longo, J. Mier, F. Aronson, R. Numerof, G. Vachino, M. Atkins, R. Kradin","doi":"10.1159/000157079","DOIUrl":"https://doi.org/10.1159/000157079","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"5 1","pages":"496-502"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64938842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteogenesis imperfecta and other inherited disorders of the structure and synthesis of type I collagen: models for the analysis of mutations that result in inherited chondrodysplasias. 成骨不全和其他I型胶原结构和合成的遗传性疾病:分析导致遗传性软骨发育不良的突变的模型。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157108
D H Cohn, P H Byers
{"title":"Osteogenesis imperfecta and other inherited disorders of the structure and synthesis of type I collagen: models for the analysis of mutations that result in inherited chondrodysplasias.","authors":"D H Cohn,&nbsp;P H Byers","doi":"10.1159/000157108","DOIUrl":"https://doi.org/10.1159/000157108","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1-2","pages":"132-8"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14198262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Autologous bone marrow purging by lymphokine-activated killer cells: rationale and prospects. 淋巴因子激活的杀伤细胞清除自体骨髓:原理和前景。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157076
S Nasr, H Sabio, E W Ades
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引用次数: 0
Toxicity of immunotherapy with interleukin-2 and lymphokine-activated killer cells. 白细胞介素-2和淋巴因子活化杀伤细胞免疫治疗的毒性。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157075
J W Mier, F R Aronson, R P Numerof, G Vachino, M B Atkins
{"title":"Toxicity of immunotherapy with interleukin-2 and lymphokine-activated killer cells.","authors":"J W Mier,&nbsp;F R Aronson,&nbsp;R P Numerof,&nbsp;G Vachino,&nbsp;M B Atkins","doi":"10.1159/000157075","DOIUrl":"https://doi.org/10.1159/000157075","url":null,"abstract":"<p><p>Immunotherapy with IL-2 represents a major breakthrough in the management of renal cell carcinoma and malignant melanoma. At present, the toxicity of most IL-2 regimens is severe and prohibitive for clinicians not intimately familiar with the myriad of side effects associated with its use. The elucidation of the mechanism by which the lymphokine induces tumor regression, the vascular leak syndrome and other side effects will permit IL-2 to be used more safely and effectively.</p>","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 6","pages":"459-76"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14111068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy. 华法林胚胎病中骨和软骨发育不良的机制。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157104
R M Pauli
{"title":"Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy.","authors":"R M Pauli","doi":"10.1159/000157104","DOIUrl":"https://doi.org/10.1159/000157104","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1-2","pages":"107-12"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14351443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
The comparative biology of chondrodysplasias in mice. 小鼠软骨发育不良的比较生物学研究。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157094
K S Brown
{"title":"The comparative biology of chondrodysplasias in mice.","authors":"K S Brown","doi":"10.1159/000157094","DOIUrl":"https://doi.org/10.1159/000157094","url":null,"abstract":"<p><p>Several monogenic mutants in mice result in chondrodysplastic dwarfism. Although they have been studied by different protocols so that the data are not strictly comparable, they represent a spectrum of genetic defects of chondrogenesis that produce chondrodysplasias in mice and, by homology, in man. Because tissues and cells of mice are available for experimental study and the genetics of mice is under experimental control, these mutants can be employed to investigate the biochemical and physiological processes that are disrupted by specific mutations. The systematic study of these disturbed developmental and biochemical pathways will increase our understanding of chondrogenesis and chondrodysplasia as similar studies have done for intermediary metabolism.</p>","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1-2","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14351450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Immunopathogenic mechanisms in experimental picornavirus-induced autoimmunity. 实验性小核糖核酸病毒诱导自身免疫的免疫致病机制。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157123
S A Huber, A Weller, M Herzum, P A Lodge, M Estrin, K Simpson, M Guthrie
{"title":"Immunopathogenic mechanisms in experimental picornavirus-induced autoimmunity.","authors":"S A Huber,&nbsp;A Weller,&nbsp;M Herzum,&nbsp;P A Lodge,&nbsp;M Estrin,&nbsp;K Simpson,&nbsp;M Guthrie","doi":"10.1159/000157123","DOIUrl":"https://doi.org/10.1159/000157123","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 4","pages":"279-91"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13990965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Natural history of human chondrodysplasias. 人类软骨发育不良的自然历史。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157099
J G Hall
{"title":"Natural history of human chondrodysplasias.","authors":"J G Hall","doi":"10.1159/000157099","DOIUrl":"https://doi.org/10.1159/000157099","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1-2","pages":"81-4"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14349613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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