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Pathology and immunopathology research最新文献

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Natural cytotoxicity of human serum. A natural IgM 'antibody' sensitizes transformed murine cells to the lytic action of complement. 人血清的天然细胞毒性。一种天然的IgM“抗体”使转化的小鼠细胞对补体的溶解作用敏感。
Pathology and immunopathology research Pub Date : 1989-01-01 DOI: 10.1159/000157138
R P Bolande, J L Arnold, D C Mayer
{"title":"Natural cytotoxicity of human serum. A natural IgM 'antibody' sensitizes transformed murine cells to the lytic action of complement.","authors":"R P Bolande,&nbsp;J L Arnold,&nbsp;D C Mayer","doi":"10.1159/000157138","DOIUrl":"https://doi.org/10.1159/000157138","url":null,"abstract":"<p><p>The natural cytotoxicity of human serum on murine L cells, EA and Sa 180 cells is expressed as a rapid cytolysis at 37 degrees C. This cytotoxic system is analyzed as to its active constituents and their functional relationships. Ultrastructural studies indicate that cell injury and death are initiated within 10 min by membrane disruption. A trypan blue assay for cell death was used to study serum toxicity in individual normal healthy adults, pregnant females and newborn infants. Pregnancy sera, particularly in the 2nd and 3rd trimesters, were consistently more toxic than male serum or nonpregnant females. Cord serum was typically nontoxic. Pools of normal fresh pregnancy serum were used for immunochemical analysis of the cytotoxic activity. By a variety of immunologic and immunochemical techniques it was shown that the cytotoxicity was, in part, due to the combined action of alternative and classical pathways of complement, the former being more prominent. The lytic action of complement was shown to be greatly amplified by the prior adsorption of IgM on the target cells' surface. This IgM is a critical determinant of the cytotoxic reaction. It probably contains a natural 'antibody' to cell surface antigen(s), whose combination activates both pathways of C.</p>","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 1","pages":"46-60"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13858735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An animal model of autoimmune sialadenitis in aged mice. 老年小鼠自身免疫性涎腺炎的动物模型。
Pathology and immunopathology research Pub Date : 1989-01-01 DOI: 10.1159/000157143
Y Hayashi, C Kurashima, M Utsuyama, K Hirokawa
{"title":"An animal model of autoimmune sialadenitis in aged mice.","authors":"Y Hayashi,&nbsp;C Kurashima,&nbsp;M Utsuyama,&nbsp;K Hirokawa","doi":"10.1159/000157143","DOIUrl":"https://doi.org/10.1159/000157143","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 2","pages":"118-24"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13879374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Immunobiology of human infection by Entamoeba histolytica. 人溶组织内阿米巴感染的免疫生物学研究。
Pathology and immunopathology research Pub Date : 1989-01-01 DOI: 10.1159/000157148
J I Ravdin
{"title":"Immunobiology of human infection by Entamoeba histolytica.","authors":"J I Ravdin","doi":"10.1159/000157148","DOIUrl":"https://doi.org/10.1159/000157148","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 3-4","pages":"179-205"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13693843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Metastatic diversity in human prostatic carcinoma: implications of growth factors and growth factor receptors for the metastatic phenotype. 人前列腺癌的转移多样性:生长因子和生长因子受体对转移表型的影响。
Pathology and immunopathology research Pub Date : 1989-01-01 DOI: 10.1159/000157154
J L Ware, S J Maygarden
{"title":"Metastatic diversity in human prostatic carcinoma: implications of growth factors and growth factor receptors for the metastatic phenotype.","authors":"J L Ware,&nbsp;S J Maygarden","doi":"10.1159/000157154","DOIUrl":"https://doi.org/10.1159/000157154","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 5-6","pages":"231-49"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13705367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Immunohistochemical localization of cytochromes P450 with polyclonal and monoclonal antibodies. 细胞色素P450多克隆和单克隆抗体的免疫组化定位。
Pathology and immunopathology research Pub Date : 1989-01-01 DOI: 10.1159/000157139
L M Anderson, J M Ward, S S Park, J M Rice
{"title":"Immunohistochemical localization of cytochromes P450 with polyclonal and monoclonal antibodies.","authors":"L M Anderson,&nbsp;J M Ward,&nbsp;S S Park,&nbsp;J M Rice","doi":"10.1159/000157139","DOIUrl":"https://doi.org/10.1159/000157139","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 2","pages":"61-94"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13804486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Author Index / Subject Index, Vol. 8, 1989 作者索引/主题索引，1989年第8卷
Pathology and immunopathology research Pub Date : 1989-01-01 DOI: 10.1159/000157162
J. Talmadge, S. Cooper, A. Fraire, P. Buffler, D. Greenberg, Claire Langston, Robert E. Lewis, M. Brackin, J. Cruse, B. Brackin, D. Butkus, S. Raju, M. Crawford, R. Krueger, K. Kirchner, J. Bower, Y. Hayashi, C. Kurashima, T. Takemura, K. Hirokawa, V. Suphiphat, S. Riengropitak, S. Sahaphong, P. Newberne, R. W. Pryor, L. Hinshaw, J. Ware, S. Maygarden
{"title":"Author Index / Subject Index, Vol. 8, 1989","authors":"J. Talmadge, S. Cooper, A. Fraire, P. Buffler, D. Greenberg, Claire Langston, Robert E. Lewis, M. Brackin, J. Cruse, B. Brackin, D. Butkus, S. Raju, M. Crawford, R. Krueger, K. Kirchner, J. Bower, Y. Hayashi, C. Kurashima, T. Takemura, K. Hirokawa, V. Suphiphat, S. Riengropitak, S. Sahaphong, P. Newberne, R. W. Pryor, L. Hinshaw, J. Ware, S. Maygarden","doi":"10.1159/000157162","DOIUrl":"https://doi.org/10.1159/000157162","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 1","pages":"333-333"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64939002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flow cytometric measurement of platelet-associated immunoglobulin. 血小板相关免疫球蛋白的流式细胞术测定。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157132
K A Ault
{"title":"Flow cytometric measurement of platelet-associated immunoglobulin.","authors":"K A Ault","doi":"10.1159/000157132","DOIUrl":"https://doi.org/10.1159/000157132","url":null,"abstract":"<p><p>The measurement of PAIg has been made very difficult by a number of technical and biological problems as outlined above. The flow cytometric approach helped to solve a number of problems. It appears to be at least as good as other techniques and better in many ways. However, it must be recognized that there remain unsolved problems. Flow cytometry has the great advantage of revealing the presence of previously unsuspected subpopulations. There is no question that such subpopulations exist, and that they are responsible, at least in part, for much of the difficulty that PAIg assays has encountered. However, at the moment we understand very little about how these subpopulations arise and what their significance is. When we can explain them it seems likely that our understanding of immune thrombocytopenia will be dramatically improved, and with it, the clinical utility of the PAIg measurement.</p>","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 5","pages":"395-408"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14200460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Antibody binding to PNS myelin proteins in acute Guillain-Barré syndrome. 抗体结合PNS髓磷脂蛋白在急性格林-巴氏综合征。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157113
S Shuman, B Zweiman, R Lisak, S Kahn, A Rostami, A Sumner
{"title":"Antibody binding to PNS myelin proteins in acute Guillain-Barré syndrome.","authors":"S Shuman,&nbsp;B Zweiman,&nbsp;R Lisak,&nbsp;S Kahn,&nbsp;A Rostami,&nbsp;A Sumner","doi":"10.1159/000157113","DOIUrl":"https://doi.org/10.1159/000157113","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 3","pages":"162-8"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14325341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of oncogenes on chondrogenesis. 致癌基因对软骨形成的影响。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157089
D Boettiger, A S Menko
{"title":"Effect of oncogenes on chondrogenesis.","authors":"D Boettiger,&nbsp;A S Menko","doi":"10.1159/000157089","DOIUrl":"https://doi.org/10.1159/000157089","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1-2","pages":"32-7"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14394782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Modulation of chondroblast phenotype by transforming growth factor-beta. 转化生长因子- β对成软骨细胞表型的调节。
Pathology and immunopathology research Pub Date : 1988-01-01 DOI: 10.1159/000157090
S M Seyedin, D M Rosen, P R Segarini
{"title":"Modulation of chondroblast phenotype by transforming growth factor-beta.","authors":"S M Seyedin,&nbsp;D M Rosen,&nbsp;P R Segarini","doi":"10.1159/000157090","DOIUrl":"https://doi.org/10.1159/000157090","url":null,"abstract":"","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"7 1-2","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
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