Kroc Foundation series最新文献

{"title":"Pharmacotherapy of diarrheal diseases: an approach based on physiologic principles.","authors":"M Donowitz, J Wicks, S Cusolito, G W Sharp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"17 ","pages":"329-59"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17217374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term bone marrow culture. Proceedings of a symposium held at the Kroc Foundation, Santa Ynez Valley, California, September 12-16, 1983.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"1-441"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17653141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical and biochemical aspects of leukocyte interactions with model vessel walls.","authors":"L V McIntire,&nbsp;S G Eskin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Leukocytes in flowing blood are continually undergoing collisions with the blood vessel walls. Whether these collisions result in adherence depends on a delicate balance between the fluid mechanical drag force, which tends to dislodge the PMNL, and the adhesive force generated at the area of contact with the endothelium. Local blood flow rate controls the first of these forces, with the important parameter being the velocity gradient at the wall (wall shear rate). The detailed morphology of the endothelial cell and the PMNL upon collision and the biochemical state of these cells determine the adhesive force, because this force is a product of the strength of interaction times the area of contact. If a leukocyte flattens out or spreads on the vessel wall surface, it will reduce the hydrodynamic drag and increase the area of contact, leading to a more stable adhesion. In the normal circulation, a significant fraction of the PMNL appear to be attached to the endothelium, particularly in the low flow venules. This leukocyte fraction is what hematology texts refer to as the marginal pool. The adherent PMNL are a dynamic population in the sense that some return to the circulation, some move through the endothelial cell mono-layer into the extravascular space, and others remain \"attached\" to the endothelial cells but roll along the surface in the flow direction. An equilibrium number is maintained under normal conditions by recruitment from the circulating pool. Increased blood flow rate will increase the hydrodynamic force, tending to dislodge the PMNL, but will also (at least in large vessels) increase the number of collisions of circulating PMNL with the vessel wall by increasing the effective \"diffusion\" coefficient of the leukocyte. Thus if one studied the kinetics of PMNL adhesion on an initially clean endothelial monolayer surface under flow, increasing the whole blood flow rate would probably increase in initial rate of attachment but may decrease the equilibrium number of adherent leukocytes (Fig. 5). The degree of cooperation in vivo between PMNL and endothelial cells required to enable the leukocytes to perform their bactericidal functions is fascinating. This type of interdependency also appears to be necessary in the inflammatory response [Wedmore and Williams, 1981]. Fluid mechanical forces in addition to biochemical events are crucial in regulating these interaction processes in vivo. In vitro models for examining PMNL adhesion should include control of the local fluid mechanics.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"209-19"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17642209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic acid-base disorders and intestinal electrolyte transport.","authors":"A N Charney,&nbsp;G M Feldman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"17 ","pages":"101-17"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17499093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental evidence for the potential usefulness of permanent IL-3-dependent multipotential hematopoietic progenitor cell lines in transfusion granulocyte support therapy: need for expansion of early passage cells.","authors":"J S Greenberger,&nbsp;M A Sakakeeny,&nbsp;A Krensky,&nbsp;S Burakoff,&nbsp;D Reid,&nbsp;T Novak,&nbsp;S S Boggs","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"255-69"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17217881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of stromal cells to hemopoietic cells in marrow.","authors":"M A Lichtman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"3-29"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17457011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural correlates of intestinal tight-junction permeability.","authors":"J L Madara,&nbsp;M A Marcial","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A variety of evidence suggests that specific parameters of tight-junction structure correlate with tight-junction function. Thus, one potential indirect means of probing the functional characteristics of paracellular pathways within epithelia at the cellular level is detailed analysis of tight-junction structure and distribution. In the small intestine such structural studies are confounded by the complex geometry and cellular heterogeneity of the epithelium, but, to date, these studies suggest this epithelium may actually consist of a moderately \"tight\" (villus) and a \"leaky\" (crypt) epithelium arranged in parallel. Moreover, it is becoming clear that both the structure and function of tight junctions, including those of the small intestine, are not static. Evidence from several epithelia indicate that a variety of factors (transepithelial osmotic gradients, cyclic nucleotides, intra- and extracellular Ca+2 concentrations) are capable of modulating tight-junction structure and function. Additionally, a variety of indirect evidence suggests that the cytoskeleton of epithelial cells may interact with the tight junction and that perhaps the alterations in junctional structure and function elicited by some of the above factors may be mediated via effects of these agents on the cytoskeleton. It may now be viewed as probable that epithelial cells have the capacity to fine-tune parameters of paracellular transport just as they do transcellular transport. We speculate that, in many instances, they may accomplish this feat by directly manipulating structural units of the tight junction via components of the cytoskeleton.</p>","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"17 ","pages":"77-100"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17451958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of hematopoiesis in long-term bone marrow culture: comparison of species differences.","authors":"C E Eastment,&nbsp;F W Ruscetti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"97-118"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17457014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deformation and activation of leukocytes--two contradictory phenomena?","authors":"P Gaehtgens","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"16 ","pages":"159-65"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17642208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent modifications of technique in human long-term bone marrow cultures.","authors":"J S Greenberger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77744,"journal":{"name":"Kroc Foundation series","volume":"18 ","pages":"119-31"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17653142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}