Isozymes最新文献_第7页

Different genome amplification mechanisms and duplicate gene expression in Liliaceae. 百合科植物不同基因组扩增机制及重复基因表达。

Isozymes Pub Date : 1983-01-01

J L Oliver, J M Martinez-Zapater, L Pascual, A M Enriquez, C Ruiz-Rejón, M Ruiz-Rejón

引用次数: 0

The utilization of polymorphic enzymes in forensic science. 多态酶在法医学中的应用。

Isozymes Pub Date : 1983-01-01

G F Sensabaugh

引用次数: 0

Subcellular localization of isozymes--an overview. 同工酶的亚细胞定位——综述。

Isozymes Pub Date : 1983-01-01

C Masters

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Chemical modification with pyridoxal 5'-phosphate as a tool in the study of ligand interactions in various lactate dehydrogenase isozymes. 以吡哆醛5′-磷酸为工具进行化学修饰，研究各种乳酸脱氢酶同工酶的配体相互作用。

Isozymes Pub Date : 1983-01-01

P C Engel

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Genetic and hormonal regulation of esterase 6 activity in male Drosophila melanogaster. 雄性黑腹果蝇酯酶6活性的遗传和激素调控。

Isozymes Pub Date : 1983-01-01

R C Richmond, C S Tepper

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Epigenetic formation of isozymes: The effect of aging. 同工酶的表观遗传形成:衰老的影响。

Isozymes Pub Date : 1983-01-01

R W Gracy

引用次数: 0

Isozymes of human phosphofructokinase: biochemical and genetic aspects. 人磷酸果糖激酶同工酶:生化和遗传方面。

Isozymes Pub Date : 1983-01-01

S Vora

{"title":"Isozymes of human phosphofructokinase: biochemical and genetic aspects.","authors":"S Vora","doi":"","DOIUrl":"","url":null,"abstract":"Human PFK is under the control of three structural loci that encode muscle-type (M), liver-type (L), and platelet-type (P) subunits. These loci are differentially expressed in various human tissues, resulting in a tissue-specific isozyme distribution patterns. Random tetramerization of these subunits produces various homotetrameric and heterotetrameric isozymes distinguishable by ion-exchange chromatography and subunit-specific mouse monoclonal antibodies. Inherited PFK deficiency is associated with five clinically and biochemically identifiable groups. The largest and best defined of these consists of the patients with glycogenosis type VII (group I). This syndrome results from a total deficiency of the catalytically active M subunit; the molecular pathology of the other four syndromes remains to be elucidated. Subunit- and species-specific hybridoma antibodies to the PFK subunits have permitted not only precise immunochemical analysis of this complex isozyme system, but also chromosomal localization of the PFK loci. In addition, immunochemical homologies among vertebrate PFKs determined using monoclonal antibodies suggest both an ancient duplication of the ancestral PFK gene and the structural conservatism of vertebrate PFK subunits despite this early divergence. Using somatic cell hybrids and subunit-specific antibodies, the PFKM, PFKP, and PFKL loci have been assigned to chromosomes I (region cen leads to q32), 10p and 21, respectively. The localization of PFKL to chromosome 21 and the chromatographic demonstration of a specific increase in the L subunit in red cells from trisomy 21 individuals has thus resolved the controversy about whether the previously observed elevation in PFK activity in Down syndrome represented a gene dosage effect. PFK exhibits both quantitative increases and isozymic shifts secondary to the altered gene expression in neoplasia. Since these alterations are correlated with the rate of growth and not the cell type of origin, PFK appears to be not only a transformation-linked but also a progression-linked discriminant of malignancy.","PeriodicalId":77729,"journal":{"name":"Isozymes","volume":"11 ","pages":"3-23"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17290511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary affinities of plant phosphoglucose isomerase and fructose-1,6-bisphosphatase isozymes. 植物磷酸葡萄糖同工酶和果糖-1,6-二磷酸酶同工酶的进化亲缘关系。

Isozymes Pub Date : 1983-01-01

N F Weeden

引用次数: 0

Genetic mapping in amphibians. 两栖动物的基因图谱。

Isozymes Pub Date : 1983-01-01

D A Wright, C M Richards, J S Frost, A M Camozzi, B J Kunz

引用次数: 0

The role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism, alcohol sensitivity, and alcoholism. 酒精脱氢酶和醛脱氢酶同工酶在酒精代谢、酒精敏感性和酒精中毒中的作用。

Isozymes Pub Date : 1983-01-01

H W Goedde, D P Agarwal, S Harada

{"title":"The role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism, alcohol sensitivity, and alcoholism.","authors":"H W Goedde, D P Agarwal, S Harada","doi":"","DOIUrl":"","url":null,"abstract":"Isozymes of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied in human organs and tissues using sensitive analytical techniques. Both ADH and ALDH showed an extensive polymorphism among different racial groups. In liver extracts and other tissues of Japanese an isozyme of ALDH (ALDH I) with a low Km for acetaldehyde was found to be deficient. The ALDH isozyme deficiency might account for the marked initial sensitivity to alcohol in Orientals owing to their impaired acetaldehyde oxidizing capacity. Significantly low erythrocyte ALDH activity was noted more frequently in chronic alcoholics than in healthy controls. After subcellular fractionation of livers from alcoholics a preferential damage of mitochondrial ALDH isozyme was observed. The metabolism of acetaldehyde has received considerable attention in the past few years, owing to the toxic effects of this substance. Rapid progress has been made in the understanding of the multiple molecular forms of ADH and ALDH in human tissues. Our recent studies have demonstrated that the isozymes of ALDH may play an important role in the pathogenesis of alcohol-related organ damage and in the biological sensitivity to alcohol in certain ethnic groups. A possible protection of ALDH I deficiency against alcoholism in Japanese has been discussed. More recent reports [Imprain et al, 1982; Jones, 1982] indicate that, in addition to the enzymatically active ALDH II, tissues from Orientals deficient in ALDH I isozyme contain enzymatically inactive, immunologically cross-reactive material homologous with ALDH I. Thus, the absence of ALDH I isozyme is not due to a regulatory mutation, a gene deletion, or a nonsense mutation, but probably results from a structural mutation.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77729,"journal":{"name":"Isozymes","volume":"8 ","pages":"175-93"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17415769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0