Drug intelligence & clinical pharmacy最新文献_第10页

Oxacillin-associated hypokalemia. Oxacillin-associated低钾血。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200909

F Schlaeffer

引用次数: 7

Methyldopa-induced syndrome of inappropriate antidiuretic hormone secretion and bone marrow granulomatosis. 甲多巴诱导的抗利尿激素分泌不当综合征与骨髓肉芽肿病。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200911

Y Varkel, A Braester, D Nusem, T Shkolnik

引用次数: 5

Calcium metabolism, calcium-channel blocking agents, and hypertension management. 钙代谢、钙通道阻滞剂和高血压管理。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200902

Y W Lam

引用次数: 3

Evaluation of passively absorbed saliva for determination of oral slow-release theophylline bioavailability in children. 被动吸收唾液测定儿童口服缓释茶碱生物利用度的评价。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200906

L M Vaughan, G Milavetz, M M Weinberger, G D Smith, J G Merrick

引用次数: 6

Ritodrine-induced erythema multiforme. Ritodrine诱导的多形性红斑。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200922

O Beitner, M Hod, S Friedman, J Ovadia, M Mimouni

{"title":"Ritodrine-induced erythema multiforme.","authors":"O Beitner, M Hod, S Friedman, J Ovadia, M Mimouni","doi":"10.1177/106002808802200922","DOIUrl":"https://doi.org/10.1177/106002808802200922","url":null,"abstract":"TO THE EDITOR: Ritodrine hydrochloride is a beta--sympathomimetic agent that significantly inhibits uterine contraction.' Some side effects of ritodrine (e.g., palpitations, tremor, nausea, vomiting) are relatively frequent;' neutropenia, metabolic disturbances, and pulmonary edema are less frequent.' We report the cases of two women who developed serious erythema multiforme during treatment. A 27-year-oldwoman, gravida I, para 0, in the 28th weekof twin pregnancy, was hospitalized because of premature contractions; the cervix was effaced 70 percent and closed. The presenting part (breech) of the first child was at station + I. The patient was given papaverine 80 mg im and dexamethasone 12mg im. Uterine contractions subsided considerably but did not disappear. At this point, ritodrine 100ltg/min iv was instituted. Five weeks after starting ritodrine therapy (33rd weekof gestation) the patient started complaining of pruritus on her abdomen, which spread to her chest and limbs. A fine maculopapular rash resemblingerythema multiforme was found on her whole body extending to the soles of her feet and palms (Figure I). There was no rash on the mucosal membranes. An extensive serological work-up was performed which proved negative for Epstein-Barr virus (EBV), cytomegalovirus (CMV), rubella, and coxsackie; Weil-Felix test, urinalysis, and cultures from skin and blood were negative. The white blood cell count (WBC) was normal, thrombocytes 170 OOO/mm', hemoglobin 10.5 g/dL, and hematocrit 31.3 g/IOOmt. Electrolytes, liver function tests, and clotting tests were normal. Ritodrine was stopped with gradual improvement of the pruritus and rash. The patient delivered twins four days later by cesarean section and the erythema disappeared after three days. Migration inhibiting factor assay (MIF) and mast cell degranulation test (MCDT) studied with ritodrine as an antigen were both negative. A 32-year-oldwoman, gravida I, para 0, was hospitalized because of premature contractions in the 27th weekof gestation. Ritodrine of 100ltg/min iv was instituted and the contractions subsided. After five weeks(32nd week of gestation) a maculopapular rash appeared on her body including her palms and the soles of her feet, accompanied by pruritus. The dermatological diagnosis was consistent with erythema multiforme (Figure 2). Urinalysis and cultures from skin and blood for bacteria and viruses were negative. Serological work-Up ruled out EBV,CMV, rubella, and coxsackie infection. The Weil-Felix test was negative. WBC, thrombocyte count, hemoglobin, hematocrit, electrolyte levels, liver function tests, and clotting tests were within normal range. MCDT","PeriodicalId":77709,"journal":{"name":"Drug intelligence & clinical pharmacy","volume":"22 9","pages":"724"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/106002808802200922","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14342978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Increased cyclosporine blood concentrations due to verapamil administration. 维拉帕米引起的环孢素血药浓度升高。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200914

T G Maggio, D W Bartels

引用次数: 20

Cefuroxime axetil. Axile头孢呋辛。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200901

M A Marx, W K Fant

引用次数: 0

NSAID dosing schedule and compliance. 非甾体抗炎药给药计划和依从性。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200927

J Jacobs, A G Goldstein, M E Kelly, B S Bloom

{"title":"NSAID dosing schedule and compliance.","authors":"J Jacobs, A G Goldstein, M E Kelly, B S Bloom","doi":"10.1177/106002808802200927","DOIUrl":"https://doi.org/10.1177/106002808802200927","url":null,"abstract":"prescriber antagonism has been encountered. Cost savings for one year have been approximately $55 000. Based on acceptance by prescribers and success of the above intervention, usage reviews have been conducted to identify other drugprescribing problems that may be amenable to intervention. In 1986-87, over $117000 was spent on parenteral metronidazole at this institution. Metronidazole also possesses characteristics that permit extended (12-hour) intervals of administration.' A review of 216 written inpatient orders revealed that 94 percent of treatment courses during a 14-weekperiod involved dosage intervals of eight hours or less. Only 4 percent of treatment courses involved 12-hour dosage intervals. In June 1987, an identical two-stage intervention was used to convert metronidazole from q8h to ql2h regimens. Again, both stages had a significant impact on prescribing ~abit~. Aft.er the persuasive stage was initiated, 27 percent of all written mpatient orders were for 12-hour dosage intervals; this increased to an average of 94 percent for 18weeks following implementation of the second sta~e of the intervention. An average of 59 percent of total orders were written by the prescriber for extended intervals. The bal~nce were s~cc~ss fully converted by therapeutic interchange. Contmuous momto~m.g shows no deviation from the above trends. To our knowledge, this IS the first report of such an intervention to increase metronidazole dosage intervals to 12 hours. Cost savings are estimated to be $24 000 in the first year of the program. The two-stage intervention was implemented in October 1986 to convert tobramycin written inpatient orders to gentamicin (except in critical care areas where pseudomonal infections warrant tobramycin usage). Annual cost savings achieved as a result of this inter~ention have been $34 000. Clindamycin will be added to the program m early 1988. This is another antibiotic for which extended (eight-hour) dosage intervals are possible and can result in a savings of $30 000 per year at this hospital. The design of this program does not permit us to evaluate whether physicians modified their prescribing behavior as a consequence of the rationale supporting extended interval dosing or in anticipation of the therapeutic interchange stage. However, the fact that prescribers had the option of requesting no substitution and did so infrequently suggests that the rationale was generally accepted and extended-interval prescribing was adopted. Perhaps prescribers would have resisted the change if therapeutic interchange had been initiated without a preceding persuasive stage. Such other factors as peer-group endorsement and the presence of preprinted orders in the patient's health record when an interchange was required may have increased compliance. Our assessments were not designed to determine the impact of each factor, but to measure the overall effectiveness of the two stages of intervention. In our institution, the combined effect","PeriodicalId":77709,"journal":{"name":"Drug intelligence & clinical pharmacy","volume":"22 9","pages":"727-8"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/106002808802200927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14342984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Flow rate variability from selected syringe and mobile infusion pumps. 从选定的注射器和移动输液泵的流量变异性。

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200907

E A Farrington, J C Stull, R D Leff

{"title":"Flow rate variability from selected syringe and mobile infusion pumps.","authors":"E A Farrington, J C Stull, R D Leff","doi":"10.1177/106002808802200907","DOIUrl":"https://doi.org/10.1177/106002808802200907","url":null,"abstract":"<p><p>Alterations in response to pharmacological agents have been attributed to flow rate variation produced by intravenous infusion devices during drug delivery. A wide range of variation has been shown to occur with large-volume infusion devices. The intent of this investigation was to examine flow variation resulting from the use of selected small-volume syringe and mobile infusion devices and determine whether these devices have greater flow continuity than large-volume infusion pumps. Each syringe and mobile infusion device delivered iv fluid at three flow rates (1, 5, and 10 ml/h). The effusate was collected in a tared beaker and serial weights were measured every ten seconds using a computerized, gravimetric technique. Accuracy, continuity, and pattern of flow were determined for each of the syringe and mobile infusion devices. All of the devices produced accurate flow, within +/- 10 percent of the desired 5 and 10 ml/h rates. However, the actual iv flow rate ranged from 53 to 93 percent for the 1 ml/h rate. Continuity and pattern of flow resulting from each device were diverse. When compared with large-volume, microrate infusion devices, no significant differences could be observed. Therefore, no clear advantage to delivering drug solutions on a continuous basis can be expected from the use of small-volume devices. Specific infusion devices may be preferable for certain clinical applications; flow continuity data may be valuable when selecting an infusion device.</p>","PeriodicalId":77709,"journal":{"name":"Drug intelligence & clinical pharmacy","volume":"22 9","pages":"687-90"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/106002808802200907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14344965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Lithium intoxication with acute renal failure and death. 锂中毒并发急性肾功能衰竭和死亡

Drug intelligence & clinical pharmacy Pub Date : 1988-09-01 DOI: 10.1177/106002808802200908

S R Rose, W Klein-Schwartz, G M Oderda, R L Gorman, W W Young

引用次数: 12