{"title":"[Future of vaccination: vaccines of the future].","authors":"P H Lagrange","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136D 3","pages":"313-34"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13566829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The expanded WHO vaccination program].","authors":"G Le Gonidec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Expanded Programme on Immunization (EPI) was established by the World Health Assembly in 1974. The EPI goal is to reduce morbidity and mortality by making immunization services available for all children of the world by 1990. General considerations on EPI vaccines, their security and efficacy, the age of administration and the number and spacing of doses are discussed. Vaccine administration, including strategies and tactics, cost effectiveness, immunization coverage and disease surveillance are reviewed.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136D 2","pages":"167-74"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15026568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leukotrienes and immediate hypersensitivity.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136D 2","pages":"221-8"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15195182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of fibronectin on the haemolytic activity of complement.","authors":"H J Kratz, T Borsos, H Isliker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sheep erythrocytes were coupled with trinitophenyl sulphonate, sensitized with anti-TNP (or-DNP) IgM monoclonal antibodies, and exposed to components of the classical pathway of complement activation. When human fibronectin (FN) was added after C1q, but before addition of C1r and C1s (subunits of the first complement component), inhibition of haemolytic activity was observed which was strictly dependent upon the dose of FN. When FN was added after addition of C1 (reconstituted from C1q, C1r and C1s), the haemolytic activity of complement was not affected by the presence of FN. These data suggest that FN binds on C1q by interfering with C1r and C1s fixation. In addition, FN was unable to displace the activated subcomponents (C1r and C1s) from their binding site on C1q. When using other systems (sheep erythrocytes sensitized with anti-Forssman IgM monoclonal antibodies), the quantity of FN required to inhibit complement haemolytic activity was greater than in the TNP system. In normal plasma, there is a 50-fold excess of FN compared to free C1q.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136D 2","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14996154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Antitumoral activity of various doses of corynebacterium parvum as a function of the age of mice].","authors":"C Stiffel, H Chalvet, C Mazurek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The anti-tumor activity of Corynebacterium parvum against two different tumours, a mammary carcinoma grafted in C3H mice and a lymphosarcoma grafted in XVII mice, was lower in young and old mice, than in adult ones. In young mice (25 days) of both lines, low doses of C. parvum were more efficient than higher doses. In 12-month old XVII mice a higher survival rate was obtained by increasing the dose of C. parvum administered, whereas in old C3H mice, this phenomenon was not observed. Sublethal doses of X-irradiation abrogated the C. parvum-induced protection. Restoration of the protective effect occurred faster in 3-month old mice than in 8-month old mice. This restoration appeared earlier in XVII mice than in C3H mice.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136D 1","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14958276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Immunological localization of alpha-fetoprotein in the proximal endoderm and its significance in extra-embryonic differentiation of teratocarcinomas in the mouse].","authors":"J A Gaillard, R Maunoury, D Buffe, C Rimbaut","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ABC technique using a specific anti-mouse alpha-foetoprotein (AFP) serum permits identification of groups of extraembryonic proximal endoderm cells in certain teratocarcinomas. These AFP+ cells are always associated with trophoblastic and parietal endodermal patterns and structures. These observations strongly support the hypothesis of a common precursor to the extraembryonic tissues which appears during the first phases of egg development.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136C 3","pages":"353-74"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13558948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enzyme-linked immunosorbent assay for measurement of penicilloyl groups.","authors":"C Lapresle, P Lafaye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An enzyme-linked immunosorbent assay for measuring penicillin groups is described. Alkaline phosphatase conjugated to penicilloyl residue was reacted with purified anti-penicilloyl antibodies coated upon polystyrene plates. The inhibition of this reaction allowed a specific determination of penicilloyl residues at the picomole level. This assay was applied to the study of the penicilloyl groups linked to human albumin and to the measurement of some of these groups after enzymatic degradation or physical modifications of the albumin molecule.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136C 3","pages":"375-82"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15149587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Roffi, P Portales, G Delgado, G Parent, S Chevassus-Agnès
{"title":"[Antigenic specificity of antiplasmodium antibodies in an endemic area: an attempt at correlation with the induction of protective immunity].","authors":"J Roffi, P Portales, G Delgado, G Parent, S Chevassus-Agnès","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Asexual blood-stage antigens from Plasmodium falciparum related to the development of protective immunity in an endemic area were identified by statistical comparison of antigens recognized by adult immune sera with those recognized by non-immune subjects (children). After metabolic labelling of parasites in culture and immunoprecipitation, target antigens of seric antibodies were separated by polyacrylamide gel electrophoresis/SDS and detected by fluorography. Two groups of antigens were thus identified: 1) the major bands, recognized by more than 90% of the sera regardless of the patients' immune status; and 2) the minor bands, less intense on fluorograms. The corresponding antibodies were more frequent in children who had not yet acquired protective immunity than in immune adults. Thus, these minor bands do not appear essential for protection, which might instead be related to the presence of some major antigens, such as 210/196-, 136-, 121- and 80-Kd antigens. These antibodies persist for at least one year, independently of fluctuations in the rate of transmission by Anopheles.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136C 3","pages":"323-41"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13558947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Fibronectins: structure and function].","authors":"M A Ouaissi, A Capron","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fibronectins are a class of high-molecular-weight glycoproteins found in a soluble form in blood and other body fluids and in an insoluble form in tissues. Cellular and plasma fibronectins are very similar in structure and properties, but are not identical. Fibronectins are synthesized by a wide variety of cells in vitro including fibroblasts, Schwann cells, chondrocytes, myoblasts, macrophages, hepatocytes and intestinal epithelial cells. They exhibit an affinity for both native and denatured forms of collagen, fibrinogen or fibrin, glycosaminoglycans, proteoglycans and surfaces of many kinds of eukaryotic cells. Fibronectins also bind to bacteria, viral glycoproteins and some protozoan parasites and interact with complement components. As a result of these multiple interactions, fibronectins might act as a non-specific opsonin. Fibronectins have been implicated in a variety of cell functions including cellular adhesion and morphology, cytoskeletal organization, oncogenic transformation, cell migration, phagocytosis, haemostasis and embryonic differentiation.</p>","PeriodicalId":77664,"journal":{"name":"Annales de l'Institut Pasteur. Immunologie","volume":"136C 2","pages":"169-85"},"PeriodicalIF":0.0,"publicationDate":"1985-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15118000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}