Advances in inorganic biochemistry最新文献

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Zinc fingers. 锌的手指。
Advances in inorganic biochemistry Pub Date : 1990-01-01
T L South, M F Summers
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引用次数: 0
Metalloregulatory proteins and molecular mechanisms of heavy metal signal transduction. 金属调控蛋白与重金属信号转导的分子机制。
Advances in inorganic biochemistry Pub Date : 1990-01-01
D M Ralston, T V O'Halloran
{"title":"Metalloregulatory proteins and molecular mechanisms of heavy metal signal transduction.","authors":"D M Ralston,&nbsp;T V O'Halloran","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review has considered what is known about the precise chemical mechanisms involved in the signal transduction of heavy metal ions. By reviewing what is known about general modes of signal transduction, we may draw parallels with the detection of and response to metal ions. In all forms of signal transduction, sensors and transducers are required. Yet, it is apparent that each system has unique features which undoubtedly are critical for the specific signal at hand. Within the context of metal-responsive systems, regardless of whether or not the metal ion is being sequestered, directly utilized, removed or otherwise, several examples of specific metalloregulatory proteins have been elucidated and are summarized in Table II. A close inspection of Table II reveals that in most signal transduction pathways for heavy metals, the presence of the metal ion causes a marked change in the nucleic acid binding capacity of the metalloregulatory protein. For example, the presence of iron results in the dissociation of a protein from iron responsive elements, thereby derepressing ferritin translation. In other instances, metal binding allows a metalloregulatory protein to associate with DNA to activate or repress transcription, as with ACE1 and Fur, respectively. In fact, to the authors' knowledge, it appears that all characterized ligand-responsive transcription factors change nucleic acid binding activity upon ligand binding. This change in affinity is a major feature of the mechanism for activation or repression by these receptors. In contrast, the mercuric ion metalloregulatory protein, MerR, operates by an entirely different transduction mechanism. MerR remains bound to its operator sequence in the presence and absence of mercuric ion, with only a slight increase in the dissociation rate constant in the presence of Hg(II). Furthermore, the site of MerR binding to the DNA is in a novel position for a prokaryotic activator, directly between the two sets of recognition sequences for RNA polymerase. Analysis of the protein-DNA interactions and transcriptional activity has demonstrated that MerR forms a complex with RNA polymerase in the absence of Hg(II) that is unstable and transcriptionally repressed. When Hg(II) is present in greater than nanomolar concentrations, a highly active transcription complex is formed at PT and a distortion at the center of the palindromic MerR binding site is detectable. Kinetic analysis has determined that, although no change in the binding of RNAP to PT is apparent, the presence of Hg(II) stimulates the rate of isomerization from the closed to the open transcription complex.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"8 ","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13358335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc fingers. 锌的手指。
Advances in inorganic biochemistry Pub Date : 1990-01-01 DOI: 10.1002/9780470034590.emrstm0607
T. L. South, M. F. Summers
{"title":"Zinc fingers.","authors":"T. L. South, M. F. Summers","doi":"10.1002/9780470034590.emrstm0607","DOIUrl":"https://doi.org/10.1002/9780470034590.emrstm0607","url":null,"abstract":"No wonder you activities are, reading will be always needed. It is not only to fulfil the duties that you need to finish in deadline time. Reading will encourage your mind and thoughts. Of course, reading will greatly develop your experiences about everything. Reading zinc fingers is also a way as one of the collective books that gives many advantages. The advantages are not only for you, but for the other peoples with those meaningful benefits.","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"8 1","pages":"199-248"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470034590.emrstm0607","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51136001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 129
Heme proteins. 血红素蛋白质。
Advances in inorganic biochemistry Pub Date : 1988-01-01
{"title":"Heme proteins.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"7 ","pages":"1-271"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14462466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heme enzyme crystal structures. 血红素酶晶体结构。
Advances in inorganic biochemistry Pub Date : 1988-01-01
T L Poulos
{"title":"Heme enzyme crystal structures.","authors":"T L Poulos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"7 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13959007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure and function of bacterial hemoglobin and related proteins. 细菌血红蛋白及相关蛋白的结构与功能。
Advances in inorganic biochemistry Pub Date : 1988-01-01
D A Webster
{"title":"Structure and function of bacterial hemoglobin and related proteins.","authors":"D A Webster","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"7 ","pages":"245-65"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14402503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemoglobin. 血红蛋白。
Advances in inorganic biochemistry Pub Date : 1988-01-01
J M Rifkind
{"title":"Hemoglobin.","authors":"J M Rifkind","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"7 ","pages":"155-244"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14402502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
c-Type cytochromes: oxidation-reduction properties. c型细胞色素:氧化还原性能。
Advances in inorganic biochemistry Pub Date : 1988-01-01
M A Cusanovich, T E Meyer, G Tollin
{"title":"c-Type cytochromes: oxidation-reduction properties.","authors":"M A Cusanovich,&nbsp;T E Meyer,&nbsp;G Tollin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"7 ","pages":"37-91"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13959008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure and function of cytochrome oxidase: a second look. 细胞色素氧化酶的结构和功能:再看。
Advances in inorganic biochemistry Pub Date : 1988-01-01
M Brunori, G Antonini, F Malatesta, P Sarti, M T Wilson
{"title":"Structure and function of cytochrome oxidase: a second look.","authors":"M Brunori,&nbsp;G Antonini,&nbsp;F Malatesta,&nbsp;P Sarti,&nbsp;M T Wilson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"7 ","pages":"93-153"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13959009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure and mechanism of carboxypeptidase A. 羧肽酶A的结构与作用机理。
Advances in inorganic biochemistry Pub Date : 1984-01-01
M W Makinen, G B Wells, S O Kang
{"title":"Structure and mechanism of carboxypeptidase A.","authors":"M W Makinen,&nbsp;G B Wells,&nbsp;S O Kang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77659,"journal":{"name":"Advances in inorganic biochemistry","volume":"6 ","pages":"1-69"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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