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[Thrombin-fibrinogen interaction: release of fibrinopeptides and the effects of ATP]. [凝血酶-纤维蛋白原相互作用:纤维蛋白肽的释放和ATP的作用]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
M A Gurrieri
{"title":"[Thrombin-fibrinogen interaction: release of fibrinopeptides and the effects of ATP].","authors":"M A Gurrieri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study presents experimental data on the time dependence of the release of fibrinopeptides A and B following the interaction between thrombin and fibrinogen. It is found that the release of fibrinopeptide A is fast as compared to that of fibrinopeptide B. This process is modulated by ATP in a complex fashion. In fact, the release of fibrinopeptide A is first enhanced at low (less than 1 mM) ATP concentrations and then progressively inhibited at ATP concentrations greater than 1 mM. These results draw attention to a possible model for the in vivo modulation of thrombin activity by ATP.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"51-2"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13530006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiovascular effects of isometric contraction of the masticatory muscles in humans]. [人类咀嚼肌等距收缩对心血管的影响]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
R Bevilacqua, P Minasi
{"title":"[Cardiovascular effects of isometric contraction of the masticatory muscles in humans].","authors":"R Bevilacqua,&nbsp;P Minasi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cardiovascular responses to static exercise do not include, until now, studies about masticatory muscles. In this work the cardiocirculatory effects of the isometric contraction of masticatory muscles were compared with those evoked by the handgrip exercise. Non invasive and, in one case, invasive (aortic catheterism) monitoring of arterial blood pressure was performed. The findings show that mean blood pressure and especially heart rate do not increase during static exercise of masticatory muscles as reported in the literature for other muscular groups: it is suggested that the peculiar architecture of masticatory muscles may explain the absence of significant cardiovascular response to their isometric contraction.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"36-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13529998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A 56-year-old man with hemoptysis and microscopic hematuria. A clinical case]. 56岁男性，咯血伴镜下血尿。一个临床病例]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
C H Coggins, J L Niles, R Fienberg
{"title":"[A 56-year-old man with hemoptysis and microscopic hematuria. A clinical case].","authors":"C H Coggins,&nbsp;J L Niles,&nbsp;R Fienberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"65-74"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13530007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Computers in emergency medicine]. [急诊医学中的计算机]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
F Aguglia, G Bertazzoni, A Scillone
{"title":"[Computers in emergency medicine].","authors":"F Aguglia,&nbsp;G Bertazzoni,&nbsp;A Scillone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Computer's applications in emergency medicine are reviewed. In the Emergency Health Care computer science provides support to the solution of medical problems (with diagnostic and medical decision making softwares) and to the management of emergency departments. Computer interfaced to instrumental equipments allows the monitoring of biomedical signals and their transmission at distance. Finally, the possibilities of computer-aided instruction are presented. Teaching methods such as the tutor-system and the simulation are discussed.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"53-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13352099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The central nervous system and inflammation: the role of opioid peptides]. [中枢神经系统和炎症:阿片肽的作用]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
A Mazzone, G Ricevuti, A Fioravanti, D Pasotti, A R Vitto, L Mirto, C Vignali, F Avato, A Notario
{"title":"[The central nervous system and inflammation: the role of opioid peptides].","authors":"A Mazzone,&nbsp;G Ricevuti,&nbsp;A Fioravanti,&nbsp;D Pasotti,&nbsp;A R Vitto,&nbsp;L Mirto,&nbsp;C Vignali,&nbsp;F Avato,&nbsp;A Notario","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Inhibition of human granulocyte aggregation was observed in the presence of morphine in a naloxone stereoselective way, while the opioid peptides were ineffective. In comparative studies Ca(+)+ (A23187) and dynorphin 1-9, per se, induced stimulation of arachidonic acid metabolites from granulocytes. In this regard dynorphin 1-9 may function as a mediator between the central nervous system and the inflammation.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"23-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13131731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Granulocytes and oxidative metabolism: role of monoclonal antibodies in superoxide anion release from neutrophils]. [粒细胞和氧化代谢:单克隆抗体在中性粒细胞超氧阴离子释放中的作用]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
A Mazzone, D Pasotti, A Fioravanti, E Uccelli, E Freddi, L Nardecchia, M Bertoldi
{"title":"[Granulocytes and oxidative metabolism: role of monoclonal antibodies in superoxide anion release from neutrophils].","authors":"A Mazzone,&nbsp;D Pasotti,&nbsp;A Fioravanti,&nbsp;E Uccelli,&nbsp;E Freddi,&nbsp;L Nardecchia,&nbsp;M Bertoldi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We studied the effects on the granulocyte oxidative metabolism of some monoclonal antibodies reacting with a membrane surface antigen fundamental for the functions of these cells. The aim of this investigation was to evaluate the role of CD11b/CD18 membrane glycoproteins on superoxide release from granulocytes. The preincubation with MoAbs 60.1, OKM1, 60.3 determined a significant decrease of anion release from granulocytes stimulated by fMLP.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"49-51"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13319667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tissue-type plasminogen activator]. 组织型纤溶酶原激活剂。
Medicina (Florence, Italy) Pub Date : 1990-01-01
F M Turazza, M Pogna
{"title":"[Tissue-type plasminogen activator].","authors":"F M Turazza,&nbsp;M Pogna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tissue-type plasminogen activator (t-PA) is a serine protease that converts a zymogen plasminogen into an active serine protease, namely, plasmin. Plasmin is the proteolytic enzyme that degrades fibrin. In the absence of fibrin, e.g., in circulating plasma, t-PA activates plasminogen at a very slow rate. However, when fibrin is present, this activity is enhanced two to three orders of magnitude. As a consequence of these kinetic characteristics, plasmin is predominantly generated on the fibrin surface. This in turn results in a relative sparing of circulating fibrinogen and other plasma proteins to plasmin--mediated degradation. Following the demonstration of the potential of natural t-PA as a thrombolytic agent, an intensive effort was launched to enhance its production by recombinant DNA technology. The pharmacological action and the clinical efficacy of t-PA has been tested by several Authors in the treatment of acute myocardial infarction (AMI), and more recently, of pulmonary embolism, a condition for which this drug seems to be very promising: from this point of view this short article provides evidence that the various thrombolytic agents are of equal ability in mediating the rapid lysis of a coronary thrombus after i.v. administration when given appropriately and at the proper time; clinical experience provides little support for the contention of the superiority of t-PA over other thrombolytic agents, particularly for coronary thrombolysis. We are waiting for the results that will come from the GISSI-2 study, that is comparing streptokinase (SK) vs. t-PA in AMI's patients.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"75-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13271621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in blood iron levels during cisplatin chemotherapy. Preliminary results]. 顺铂化疗期间血铁水平的变化。初步结果)。
Medicina (Florence, Italy) Pub Date : 1990-01-01
S Sartori, I Nielsen, P Malacarne
{"title":"[Changes in blood iron levels during cisplatin chemotherapy. Preliminary results].","authors":"S Sartori,&nbsp;I Nielsen,&nbsp;P Malacarne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Iron levels during cisplatin chemotherapy were evaluated in 23 neoplastic patients who received a total of 59 courses of cisplatin 80-100 mg/m2. In all cases hypersideraemia developed within 24 hours: iron mean value increased from 70.5 micrograms/dl to 237.4 micrograms/dl (p less than 0.001). Return to basal levels was achieved after 8-9 days. Indirect bilirubin, lactic-dehydrogenase, haemoglobin and red cells levels remained unmodified; reticulocyte count decreased only after 4 days, so making unlikely that a drug-induced haemolysis or a reduced iron utilization by inhibitory effect of cisplatin on erithron could be the cause of hypersideraemia, which at this moment remains unexplained.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"48-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13530004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Identification of human herpesvirus HHV-6 sequence in a case of Hodgkin's disease by polymerase chain reaction]. [用聚合酶链反应鉴定一例霍奇金病的人疱疹病毒HHV-6序列]。
Medicina (Florence, Italy) Pub Date : 1990-01-01
R Marasca, M Luppi, M Montorsi, M Fancinelli, R Sabbatini, M T Mariano, L Selleri
{"title":"[Identification of human herpesvirus HHV-6 sequence in a case of Hodgkin's disease by polymerase chain reaction].","authors":"R Marasca,&nbsp;M Luppi,&nbsp;M Montorsi,&nbsp;M Fancinelli,&nbsp;R Sabbatini,&nbsp;M T Mariano,&nbsp;L Selleri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the last decades new approaches to the diagnosis and treatment of Hodgkin's Disease (HD) have contributed to improved rates of survival and cure but the pathogenesis of the disease still remains unknown. Data have been collected suggesting a relationship between viral infections and HD. HD patients with evidence of Epstein-Barr virus genomes in their affected tissues have been recently reported. Human Herpes Virus six (HHV-6) is a newly isolated virus, derived from patients with lymphoproliferative disorders. In order to investigate the possible role of this virus in the pathogenesis of HD we looked for a specific segment of HHV-6 genome by means of the polymerase chain reaction (PCR) in tissue samples obtained from peripheral blood and lymphnodes in HD patients: one clearly positive case has been identified. This result is the first indication of HHV-6 sequences associated with a case of HD and raises the possibility that this virus might be involved in the pathogenesis of this lymphoproliferative disorder. The relationship between HHV-6 and HD therefore warrants further investigation.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 1","pages":"43-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13319663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Proposal of a new staging system using scoring of multiple myeloma]. [使用多发性骨髓瘤评分的新分期系统的建议]。
Medicina (Florence, Italy) Pub Date : 1989-10-01
P Pasqualetti, A Collacciani, R Casale, D Colantonio
{"title":"[Proposal of a new staging system using scoring of multiple myeloma].","authors":"P Pasqualetti,&nbsp;A Collacciani,&nbsp;R Casale,&nbsp;D Colantonio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new simple scoring staging system was developed and evaluated in 121 cases of multiple myeloma, followed from first diagnosis to demise. A score of 1 was assigned to each of the following features: bone marrow plasma cells more than 30%, hemoglobinemia less than 11 g/dl, lytic bone lesions of degrees 2-3, presence of Bence Jones proteinuria and serum beta 2-microglobulin levels higher than 8.0 micrograms/ml. Therefore, the score for each patient ranged from 0 to 5, corresponding to six risk classes: score 0 = class I; score 1 = class II; score 2 = class III; score 3 = class IV; score 4 = class V; score 5 = class VI. Since no differences in mean survivals and in survival curves were found between classes I and II, between classes III and IV and between classes V and VI, three stages could be devised: stage A (good prognosis) corresponding to classes I and II; stage B (intermediate prognosis) corresponding to classes III and IV; stage C (poor prognosis) corresponding to classes V and VI. Significant differences were found among the three stages regarding mean survivals, survival curves, and response to treatment. This scoring staging system is very simple in its formulation; only five routine parameters and no calculations are necessary for obtaining a score and consequently a stage for each patient. Moreover, the system can identify categories of multiple myeloma patients with homogeneous characteristics since it appears to be correlated with response to treatment and survival.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"9 4","pages":"410-3"},"PeriodicalIF":0.0,"publicationDate":"1989-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13777523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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