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[Gastrin tissue levels in patients with peptic ulcer: a different methodological approach]. [消化性溃疡患者胃泌素组织水平:一种不同的方法学方法]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
B Germanà, P Dal Santo, F Vianello, D Faggian, M Plebani, L Gottardello, G Leandro, F Di Mario, R Naccarato
{"title":"[Gastrin tissue levels in patients with peptic ulcer: a different methodological approach].","authors":"B Germanà,&nbsp;P Dal Santo,&nbsp;F Vianello,&nbsp;D Faggian,&nbsp;M Plebani,&nbsp;L Gottardello,&nbsp;G Leandro,&nbsp;F Di Mario,&nbsp;R Naccarato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The function of G cells has been mainly evaluated by serum gastrin. A different analytical approach considers the direct determination of gastrin levels (ng/g of wet tissue) in perendoscopic biopsies, but, up to now, the results are contradictory. In the present study we evaluated, by means of a RIA method, the concentration of gastrin (ng/g of protein nitrogen) in homogenized gastroduodenal biopsies in 127 patients with peptic ulcer and in 12 dyspeptic patients. The results demonstrated: 1) a significant gradient of gastrin concentrations among the different anatomical sites, according to the distribution of the G cells; 2) a correlation with serum gastrin levels; 3) a good equivalence of gastrin content in adjacent biopsy specimens. This preliminary report indicates that it is possible directly quantitate tissue levels of gastrin by means of an accurate and simple method.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"292-4"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bronchial reactivity and cough due to ACE inhibitors]. [ACE抑制剂引起的支气管反应性和咳嗽]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
P A Canessa, A Torraca
{"title":"[Bronchial reactivity and cough due to ACE inhibitors].","authors":"P A Canessa,&nbsp;A Torraca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The occurrence of a dry, nonproductive cough during ACE inhibitors therapy has been described in several reports. However, the mechanism of this effect is still unknown. In order to clarify whether ACE inhibitor-induced cough is a symptom of an asthmatic disturbance, six patients (age 54-68) with cough related to captopril or enalapril were rechallenged with ACE inhibitors after an adequate washout period. Baseline airway function and bronchial reactivity to metacholine were measured at the end of the washout period and on the fourth day of rechallenge which was accompanied by the reappearance of cough without wheezing. Rechallenge did not cause changes in dynamic lung function; a low and not significant (p less than 0.1) increase in metacholine dose causing a 15% and a 20% reduction in baseline FEV 1 was observed. It is concluded that cough and bronchoconstriction are likely to be mediated through different nervous pathways and that ACE inhibitor-induced cough is not a variant of asthmatic cough.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"296-8"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in upper gastrointestinal motility during scleroderma]. [硬皮病期间上消化道运动的变化]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
G Bassotti, C Betti, M A Pelli, A Morelli
{"title":"[Changes in upper gastrointestinal motility during scleroderma].","authors":"G Bassotti,&nbsp;C Betti,&nbsp;M A Pelli,&nbsp;A Morelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Scleroderma (progressive systemic sclerosis) is a systemic collagen disease in which the upper gut is frequently involved. In particular, most patient show altered esophageal motility, which frequently result in severe esophagitis, often resistant to therapeutic measures. The small bowel is also frequently involved by the disease, especially in the late stage of scleroderma. Small bowel alterations are sometimes clinically silent, but can also be the origin of malabsorption syndrome, small intestine perforation, pneumatosis cystoides or chronic intestinal pseudo-obstruction. The occurrence of an altered gastrointestinal motility in scleroderma can be detected by means of manometric techniques; their use in the wide area of collagenopathies may help understanding the pathophysiology of the altered gastrointestinal function frequently existing in these diseases.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"251-5"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13234945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The opinions of general practitioners on alcohol abuse]. [全科医生对酒精滥用的看法]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
V di Ciommo, F Ferrario
{"title":"[The opinions of general practitioners on alcohol abuse].","authors":"V di Ciommo,&nbsp;F Ferrario","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A postal survey has been carried out in order to know the attitudes of general practitioners concerning the harmful effects of alcohol. Only 18% of the 150 physicians of a roman suburban area involved in the survey returned the questionnaire. According to a quarter of them a daily intake of wine larger than 600 ml (65 g of alcohol) in man and 500 ml in women is still unharmful. Anamnesis, behaviour disturbances, liver enlargement and \"liver enzymes\" were considered the most useful diagnostic procedures. Every preventive strategy emphasizing the role of general practitioners has to take into account the need of appropriate guidelines.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"280-1"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13234949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The primary empty sella syndrome: a clinical and neuroradiological study of 10 cases]. 原发性空蝶鞍综合征:10例临床和神经影像学研究。
Medicina (Florence, Italy) Pub Date : 1990-07-01
V Sacco Vinci, A Maioli, G Citro, S De Marca, M L Vinci
{"title":"[The primary empty sella syndrome: a clinical and neuroradiological study of 10 cases].","authors":"V Sacco Vinci,&nbsp;A Maioli,&nbsp;G Citro,&nbsp;S De Marca,&nbsp;M L Vinci","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary empty sella is an anatomical entity in which an enlarged pituitary fossa is partially filled with cerebrospinal fluid owing to the arachnoid herniation and the pituitary gland is compressed against the fossa. This condition can be due to an inherent weakness of the diaphragma of the sella as well as to an increase in intracranial pressure. Empty sella can be associated with neuroradiological and endocrine symptoms and the present study reports the clinical, endocrine and radiological features in 10 patients with primary empty sella syndrome. We conclude that the endocrine alterations are frequent in the empty sella syndrome and that the most specific and sensible neuroradiological investigation is N.M.R.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"273-7"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13234947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnostic echography in tumefactions of the parotid space]. [腮腺间隙肿大的超声诊断]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
R L Bevilacqua, F Lancia, A Buccilli
{"title":"[Diagnostic echography in tumefactions of the parotid space].","authors":"R L Bevilacqua,&nbsp;F Lancia,&nbsp;A Buccilli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The reliability of the echographic approach to the diagnosis of expansive lesions of the parotid area has been evaluated by comparing in 45 patients the echographic data with the results of the clinical and/or histopathological investigations. There was a satisfactory agreement between conclusions based on the two approaches. In particular, echography was able to differentiate between: (a) intra- and extraglandular nodules; (b) diffuse and focal involvement of the gland and, (c) malignant and nonmalignant proliferative processes.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"278-80"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13234948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ulcerative colitis, thromboses of the cavernous sinuses and prostatic plexus and acute necrotizing hemorrhagic leukoneuraxitis: a case report of a syndromal association]. 溃疡性结肠炎、海绵窦和前列腺丛血栓形成和急性坏死性出血性白神经轴炎:一例综合征相关性报告。
Medicina (Florence, Italy) Pub Date : 1990-07-01
A Teggi, C Della Rocca, F Traditi, C M Lanzalone, F De Rosa
{"title":"[Ulcerative colitis, thromboses of the cavernous sinuses and prostatic plexus and acute necrotizing hemorrhagic leukoneuraxitis: a case report of a syndromal association].","authors":"A Teggi,&nbsp;C Della Rocca,&nbsp;F Traditi,&nbsp;C M Lanzalone,&nbsp;F De Rosa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors describe a case of ulcerative colitis initially complicated by priapism due to cavernous sinus thrombosis and by prostatic plexus thrombosis and, subsequently, by a fatal acute necrotizing hemorrhagic leukoencephalitis. This complex and, apparently, until now unreported association supports the view that ulcerative colitis is the expression of a systemic disease. It also raises important pathogenetic problems which are discussed in connection with the vascular complications of ulcerative colitis reported in the literature.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"286-91"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13234952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Otology in diseases of internal medicine interest]. [内科疾病中的耳科]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
D Megighian
{"title":"[Otology in diseases of internal medicine interest].","authors":"D Megighian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Many clinical manifestations present signs of cochleovestibular impairment. In some cases, otological symptoms are a complication of a disease, while in other cases they are the only early signs and can last for a long period preceding the full development of the primary disease. The otological pathology in the former case is useful for investigating the internal pathology and sometimes for delivering correct diagnosis. On the contrary, in the latter case, it does not offer elements for any etiopathogenic hypothesis because it happens in almost all cases with an acute onset in an otherwise healthy subject and it is always underestimated because of the minor functional impairment. However, clinical studies in the last years led to a significant evolution of otological findings as an early important symptom in the etiopathogenic study and in the diagnosis of some internal diseases. This is true for connectivitis, in which the disease is often preceded by a sudden cochleovestibular symptom, in some dismetabolic or vascular diseases that sometimes begin with fluctuating hearing loss, or in some cochlear manifestations due to ototoxic origin.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"337-42"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The H2-antagonist therapy withdrawal syndrome: the possible role of hyperprolactinemia]. [h2拮抗剂治疗戒断综合征:高泌乳素血症的可能作用]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
L Rampello, G Nicoletti
{"title":"[The H2-antagonist therapy withdrawal syndrome: the possible role of hyperprolactinemia].","authors":"L Rampello,&nbsp;G Nicoletti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patients previously treated with H2-receptor blocking agents (cimetidine or ranitidine) exhibited a complex neurobehavioral and gastroenteric syndrome, including anxiety, insomnia, anorexia, growing thin, irritability, tachycardia, diarrhoea, nausea, vomiting, abdominal pain, headache, vertigo. These symptoms were dramatically reduced by administration of cimetidine or ranitidine, and reappeared with a new suspension of the therapy. The withdrawal syndrome from H2-receptor antagonists was reversed by treatment with domperidone (10 mg three times per day), a potent hyperprolactinaemic drug which does not cross the blood brain barrier. These results suggest that the drop in prolactin levels that occurs when cimetidine or ranitidine are suspended may contribute to the development of the withdrawal syndrome.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"294-6"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13140672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New vaccinations: compulsory or not?]. [新的疫苗接种:强制与否?]。
Medicina (Florence, Italy) Pub Date : 1990-07-01
L Ortona, E Pizzigallo
{"title":"[New vaccinations: compulsory or not?].","authors":"L Ortona,&nbsp;E Pizzigallo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to contribute to the discussion of compulsory vaccinations a brief review of those vaccines that have been extensively used so far is presented. Such review reflects the urgency to update the vaccine schedule presently in use in our country, following WHO recommendations. In Italy, hepatitis B vaccination will soon be made compulsory by law for all newborns and children at the age of 12. As far as measles, mumps and rubella are concerned there is no universal agreement on whether to vaccinate the newborns or not because there is a theoretical risk of delaying the occurrence of these infections to a later age. Such risk could be easily reduced by allowing for booster doses of vaccine at the beginning of primary school. Only pilot studies would provide evidence on the effectiveness of the new vaccines for whooping cough and varicella-zoster and on the opportunity of vaccinating newborns for these infections. For all the others available and experimental vaccines it is too early to consider their inclusion among the compulsory vaccines although the rapid pace of the research in this field makes it quite likely that vaccination schedule will be soon extended.</p>","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 3","pages":"303-8"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13122564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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