Biomedical science最新文献_第2页

Molecular-biological and immunological properties of ribosomal vaccines. 核糖体疫苗的分子生物学和免疫学特性。

Biomedical science Pub Date : 1991-01-01

L V Nikolaeva, E P Savel'ev

引用次数: 0

ADP-ribosyltransferase activity of Legionella pneumophila is stimulated by the presence of macrophage lysates. 嗜肺军团菌adp核糖基转移酶活性被巨噬细胞裂解物刺激。

Biomedical science Pub Date : 1991-01-01

Belyi YuF, I S Tartakovskii, Vertiev YuV, S V Prosorovskii

引用次数: 0

On the ionic cyclotron resonance in biomolecules. 生物分子中的离子回旋共振。

Biomedical science Pub Date : 1991-01-01

D S Chernavskii, M V Vol'kenshtein

引用次数: 0

Factors within the body determining the glycogen reserves in the tissues of rats with transplantable tumours. 体内决定可移植肿瘤大鼠组织中糖原储备的因素。

Biomedical science Pub Date : 1991-01-01

V P Shelepov, V A Chekulaev, G R Pasha-Zade

{"title":"Factors within the body determining the glycogen reserves in the tissues of rats with transplantable tumours.","authors":"V P Shelepov, V A Chekulaev, G R Pasha-Zade","doi":"","DOIUrl":"","url":null,"abstract":"Attempts have been made to determine the reason for the depletion of glycogen reserves in tumour-bearing rats. The possible roles of anorexia, competition for glucose by the tumour, and lack of hormonal control of glycogen biosynthesis have been investigated. The glycogen content of the liver, skeletal muscle, and brain, and the levels of glucose and the hormones corticosterone, insulin, and glucagon were determined in healthy rats which had been starved for various periods and in tumour-bearing rats carrying the fast-growing Zajdela ascites hepatoma or the slow-growing solid hepatoma 27. It was found that towards the terminal stages of tumour development there was an increase in the content of corticosterone and glucagon in the blood serum and also an increase in the glycogen reserves in skeletal muscle and brain despite the presence of hypoglycaemia and hypo-insulinaemia. There was at this time a sharp fall in the level of liver glycogen. It is shown that neither anorexia nor excessive competition for glucose by the tumour were the main reasons for liver glycogen depletion and hypoglycaemia. A strong correlation was observed, however, between the occurrence of anaemia and the loss of liver glycogen, which suggests that the former may be an important factor in the changes in host tissue observed in response to tumour growth.","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 2","pages":"111-20"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12935359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptation to short-term stress prevents post-infarction hyperactivation of the endothelium and decrease in blood pressure in rats. 对短期应激的适应可防止大鼠梗死后内皮细胞的过度活化和血压的降低。

Biomedical science Pub Date : 1991-01-01

F Z Meerson, E B Manukhina, A V Lapshin

引用次数: 0

Secretory function of cells in the rat metrial gland. 大鼠子宫腺细胞的分泌功能。

Biomedical science Pub Date : 1991-01-01

V M Mikhailov

{"title":"Secretory function of cells in the rat metrial gland.","authors":"V M Mikhailov","doi":"","DOIUrl":"","url":null,"abstract":"The immunochemical determination of antigens, products of the secretory activity of metrial gland cells, in the serum of pregnant rats is described. In order to prepare a specific immune antiserum, rabbits were immunised with homogenates of the rat metrial gland removed at day 15 of pseudopregnancy. The resultant immune antisera were adsorbed by glutaraldehyde-polymerised sera from nonpregnant rats until the Ouchterlony test ceased to give a positive reaction with sera of nonpregnant rats. These adsorbed specific sera continued to react with sera of pregnant and pseudopregnant animals, indicating that the latter both contain one or more antigens identical to those produced by the cells of the metrial gland, and against which the specific antisera had been raised. When 10% and 15% fresh serum from nonpregnant females was added to molten agar or was initially dropped into wells in the agar, the positive reaction between the specific antisera and the sera of pregnant and pseudopregnant rats was not eliminated. An antigen identical to the serum antigen was also found in amniotic fluid, in sera, and in extracts of metrial glands from pregnant and pseudopregnant laboratory animals. The data obtained indicate that cells in the metrial gland have a secretory function. It is proposed that the serum antigen of pregnant and pseudopregnant rats is secreted by the granular cells in the metrial gland.","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 5","pages":"477-80"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13003025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibodies reveal structural similarity between cytoskeletal filaments and a model nucleopeptide. 单克隆抗体揭示了细胞骨架细丝和模型核肽之间的结构相似性。

Biomedical science Pub Date : 1991-01-01

T E Semenov, S F Barbashov, A N Surovaya, I I Fridlyanskaya

{"title":"Monoclonal antibodies reveal structural similarity between cytoskeletal filaments and a model nucleopeptide.","authors":"T E Semenov, S F Barbashov, A N Surovaya, I I Fridlyanskaya","doi":"","DOIUrl":"","url":null,"abstract":"The cytoskeleton is considered to be a very important cellular component, playing a role in the interactions between different organelles. However, in many cases the true biochemical functions and some of the structural aspects of cytoskeletal filaments are still unknown. Several hybridoma cell lines producing monoclonal antibodies (Mab) against a complex of linear DNA with the tridecapeptide Dns-NH2-VVTGVKTGVKTVT-CO2H have been established. (Dns is 5-methylaminonaphthalene-1-sulphonic acid.) The organization of this complex, in which the DNA is in a compact form, has been well-characterized previously by physicochemical methods and electron microscopy. A monoclonal antibody, Mab 66/9, was selected for further study on the basis of its reactivity with the immunizing DNA-peptide complex and minimal reaction with DNA alone. In immunofluorescence studies with cultured cells, this Mab did not recognize any nuclear structures, but reacted with cytoskeletal intermediate filaments and with nuclear lamins. Thus, Mab 66/9 appears to define an epitope present in the immunizing DNA-peptide complex and in cytoskeletal elements. The epitope is probably determined by the conformation of the oligopeptide since it was not detected in denatured cell lysates. Our observations provide some indirect evidence in support of the DNA-binding properties of cytoskeletal components which have been hypothesized in some recent publications.","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 5","pages":"498-502"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13003028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct recording of postcapillary resistance in cat skeletal muscle: measurement in the presence of humoral stimuli. 直接记录猫骨骼肌毛细血管后阻力:体液刺激下的测量。

Biomedical science Pub Date : 1991-01-01

B I Tkachenko, Kudryashov YuA

引用次数: 0

The participation of cAMP and protein kinase C in the regulation of aldosterone biosynthesis by potassium. cAMP和蛋白激酶C参与钾对醛固酮生物合成的调节。

Biomedical science Pub Date : 1991-01-01

V M Pushkarev, A S Mikosha

引用次数: 0

Construction and properties of fusion proteins between human interferon-gamma and human tumour necrosis factors alpha and beta. 人干扰素- γ与人肿瘤坏死因子α和β融合蛋白的构建和性质。

Biomedical science Pub Date : 1991-01-01

V G Korobko, I V Davydov, L N Shingarova, S A Filippov, D S Esipov, V N Dobrynin

引用次数: 0