Arteriosclerosis (Dallas, Tex.)最新文献_第7页

Secular trends in atherosclerosis of coronary arteries and basal cerebral arteries in Japan. The Akita pathology study. 日本冠状动脉和脑基底动脉动脉粥样硬化的长期趋势。秋田的病理研究。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-07-01 DOI: 10.1161/01.atv.10.4.535

M Konishi, Y Komachi, H Iso, M Iida, Y Naito, S Sato, M Kiyama, T Shimamoto, A Kitamura, M Doi

{"title":"Secular trends in atherosclerosis of coronary arteries and basal cerebral arteries in Japan. The Akita pathology study.","authors":"M Konishi, Y Komachi, H Iso, M Iida, Y Naito, S Sato, M Kiyama, T Shimamoto, A Kitamura, M Doi","doi":"10.1161/01.atv.10.4.535","DOIUrl":"https://doi.org/10.1161/01.atv.10.4.535","url":null,"abstract":"The atherosclerotic lesions of the coronary arteries and basal cerebral arteries in the circle of Willis were examined in the bodies of decreased men ages 30 and over who had been admitted to a local hospital in northeast Japan during 1966 to 1974 (243 men) and 1975 to 1984 (602 men). The autopsy rates during the two periods were 86% and 89%, respectively. The extent of atherosclerosis was determined blindly by one pathologist using a grading method of cross-sectional stenosis scoring for coronary arteries and Baker's method for basal cerebral arteries. The age-adjusted mean scores for atherosclerosis in the coronary arteries and basal cerebral arteries were 30% and 42% lower, respectively, in the 1975 to 1984 period than in the 1966 to 1974 period (p less than 0.001). There was also a fall in age-adjusted blood pressure levels at admission: 10 mm Hg for systolic and 4 mm Hg for diastolic blood pressure (p less than 0.001). The opposite trend was seen in mean serum cholesterol: a rise from 171 mg/dl to 177 mg/dl (p = 0.018). Linear regression analysis indicated that blood pressure was positively associated with both atherosclerosis scores, controlling for age and serum cholesterol in both time periods (p less than 0.001). The association of serum cholesterol with the atherosclerosis scores was positive in both periods and statistically significant in 1975 to 1984. Similar findings were obtained when the analyses were conducted for cardiovascular disease (myocardial infarction and stroke) and for noncardiovascular disease, separately.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 4","pages":"535-40"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.4.535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13518113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit. 鱼油对渡边遗传性高脂血症家兔动脉粥样硬化的影响。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-07-01 DOI: 10.1161/01.atv.10.4.597

A H Lichtenstein, A V Chobanian

{"title":"Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit.","authors":"A H Lichtenstein, A V Chobanian","doi":"10.1161/01.atv.10.4.597","DOIUrl":"https://doi.org/10.1161/01.atv.10.4.597","url":null,"abstract":"The effect of dietary supplementation with fish oil was investigated in the Watanabe heritable hyperlipidemic (WHHL) rabbit. Rabbits were fed Maxepa (1 g/kg body weight) from weaning for a 6-month period and were compared to controls. Fish oil supplements resulted in significant decreases in plasma triglyceride and cholesterol at 4 weeks after the start of the study, and these differences persisted over the 6-month period. No differences in the distribution of cholesterol or triglyceride among lipoprotein particles were found, nor were there differences in low density lipoprotein particle size. The decreases in plasma cholesterol and triglyceride were accompanied by significant increases in the percent of eicosapentaenoic and docosahexaenoic acids in both plasma and platelets. Fish oil supplementation resulted in a decrease in platelet count and response to the aggregating agents adenosine diphosphate, arachidonic acid, and collagen. Systolic blood pressure was significantly lower in the rabbits fed fish oil. At the end of the study period, aortic free and esterified cholesterol and intimal surface area covered with plaque were determined in the arch and in the descending and abdominal aorta. Significantly less cholesterol was found in the descending and abdominal aorta. These differences were mirrored by decreased activities of acid lipase and N-acetyl-beta-glucosaminidase. In contrast, no differences in the intimal surface area covered with plaque were found. In conclusion, dietary fish oil resulted in a decrease in aortic lipid deposition in the WHHL rabbit, which may have been due to decreases in plasma triglyceride and cholesterol, platelet count and aggregability, and systolic blood pressure.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 4","pages":"597-606"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.4.597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13518119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. 体脂、血浆脂蛋白与心血管疾病的区域分布。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-07-01 DOI: 10.1161/01.atv.10.4.497

J P Després, S Moorjani, P J Lupien, A Tremblay, A Nadeau, C Bouchard

{"title":"Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.","authors":"J P Després, S Moorjani, P J Lupien, A Tremblay, A Nadeau, C Bouchard","doi":"10.1161/01.atv.10.4.497","DOIUrl":"https://doi.org/10.1161/01.atv.10.4.497","url":null,"abstract":"Several epidemiological studies have reported that the regional distribution of body fat is a significant and independent risk factor for cardiovascular disease (CVD) and related mortality. Although these associations are well established, the causal mechanisms are not fully understood. Numerous studies have, however, shown that specific topographic features of adipose tissue are associated with metabolic complications that are considered as risk factors for CVD such as insulin resistance, hyperinsulinemia, glucose intolerance and type II diabetes mellitus, hypertension, and changes in the concentration of plasma lipids and lipoproteins. The present article summarizes the evidence on the metabolic correlates of body fat distribution. Potential mechanisms for the association between body fat distribution, metabolic complications, and CVD are reviewed, with an emphasis on plasma lipoprotein levels and plasma lipid transport. From the evidence available, it seems likely that subjects with visceral obesity represent the subgroup of obese individuals with the highest risk for CVD. Although body fat distribution is now considered as a more significant risk factor for CVD and related death rate than obesity per se, further research is clearly needed to identify the determinants of body fat distribution and the causal mechanisms involved in the metabolic alterations. It appears certain, however, that an altered plasma lipid transport is a significant component of the relation between body fat distribution and CVD.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 4","pages":"497-511"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.4.497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13350084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1351

"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. “门静脉”脂肪组织是心血管疾病和糖尿病危险因素的产生者。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-07-01 DOI: 10.1161/01.ATV.10.4.493

P. Björntorp

引用次数: 1184

Heterogeneity of N-linked sugar chains of apolipoprotein B-100 in Watanabe heritable hyperlipidemic and fasting rabbits. 渡边遗传性高脂血症和空腹家兔载脂蛋白B-100 n链糖链的异质性。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-05-01 DOI: 10.1161/01.atv.10.3.386

M Tsunemitsu, Y Ishikawa, T Taniguchi, H Fukuzaki

{"title":"Heterogeneity of N-linked sugar chains of apolipoprotein B-100 in Watanabe heritable hyperlipidemic and fasting rabbits.","authors":"M Tsunemitsu, Y Ishikawa, T Taniguchi, H Fukuzaki","doi":"10.1161/01.atv.10.3.386","DOIUrl":"https://doi.org/10.1161/01.atv.10.3.386","url":null,"abstract":"We have elucidated the structures of N-linked sugar chains of human apolipoprotein (apo) B-100 (Arch Biochem Biophys 1989; 273:197-205). To investigate the role of the carbohydrate moieties of apolipoprotein B-100, we determined the structures of the N-linked sugar chains of apo B-100 purified from low density lipoprotein (LDL) of a Watanabe heritable hyperlipidemic (WHHL) rabbit and compared them with those of fasting Japanese White rabbits. The N-linked oligosaccharides of apo B-100 were liberated by hydrozinolysis, followed by NaB3H4 reduction, and were fractionated by paper electrophoresis and Bio-Gel P-4 column chromatography. These consisted of one neutral fraction (N) and two acidic fractions (A1 and A2) in both WHHL and fasting rabbits. N contained high mannose type oligosaccharides consisting of Man5GlcNAc2 to Man9GlcNAc2. A1 and A2 contained monosialylated and disialylated biantennary complex type oligosaccharides, respectively. The molar ratios of N, A1, and A2 were 5:2:2 in the WHHL rabbit and 4:2:5 in fasting rabbits. The content of sialic acid residues in the WHHL rabbit was calculated to be 0.64 by taking the value of that in fasting rabbits as 1.0. These results show the heterogeneity of N-linked sugar chains of apo B-100 in WHHL and fasting rabbits and suggest the possibility that the characteristics of LDL in WHHL rabbits may be altered by making the surface charge more positive than in fasting rabbits.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 3","pages":"386-93"},"PeriodicalIF":0.0,"publicationDate":"1990-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.3.386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Phenotypic effects of apolipoprotein structural variation on lipid profiles. III. Contribution of apolipoprotein E phenotype to prediction of total cholesterol, apolipoprotein B, and low density lipoprotein cholesterol in the healthy women study. 载脂蛋白结构变异对脂质谱的表型影响。3健康女性研究中载脂蛋白E表型对总胆固醇、载脂蛋白B和低密度脂蛋白胆固醇预测的贡献

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-05-01 DOI: 10.1161/01.atv.10.3.379

J E Eichner, L H Kuller, R E Ferrell, E N Meilahn, M I Kamboh

{"title":"Phenotypic effects of apolipoprotein structural variation on lipid profiles. III. Contribution of apolipoprotein E phenotype to prediction of total cholesterol, apolipoprotein B, and low density lipoprotein cholesterol in the healthy women study.","authors":"J E Eichner, L H Kuller, R E Ferrell, E N Meilahn, M I Kamboh","doi":"10.1161/01.atv.10.3.379","DOIUrl":"https://doi.org/10.1161/01.atv.10.3.379","url":null,"abstract":"The apolipoprotein (apo) E structural locus has been shown to influence concentrations of total cholesterol, apo B, and low density lipoprotein (LDL) cholesterol in population studies. Apo E has six phenotypes resulting from three common alleles at this locus. In the present study, we have typed 473 healthy white women for apo E. At baseline in 1984, all women were premenopausal. To date, 109 of these women have become postmenopausal and are not on hormone therapy. Statistical analyses were done on both pre- and postmenopausal groups to assess the influence of menopausal status in combination with the apo E locus on lipid profile. Nine lipoprotein lipids and apolipoproteins were categorized by three apo E phenotypes: apo E3-2, apo E3-3, and apo E4-3. These were compared in analysis of variance. At baseline, the apo E3-2 phenotype showed the lowest average concentrations of total cholesterol (170 mg/dl), apo B (80 mg/dl), and LDL cholesterol (91 mg/dl), while the apo E4-3 phenotype demonstrated the highest average concentrations of total cholesterol (192 mg/dl), apo B (104 mg/dl), and LDL cholesterol (116 mg/dl) (p less than or equal to 0.0004). Apo E3-3 homozygotes were intermediate on all three quantitative variables. The postmenopausal subset showed the same trends by phenotype, with overall increases in total cholesterol, apo B, LDL cholesterol, and triglycerides, regardless of phenotype. Women who remained premenopausal generally showed smaller increases in these same measures. Our results suggest that, on average, the lower lipoprotein values for the apo E3-2 phenotype are maintained through early menopause despite a worsening of lipid profiles for all women as they age.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 3","pages":"379-85"},"PeriodicalIF":0.0,"publicationDate":"1990-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.3.379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

Polymorphism in 5' flanking region of human insulin gene. Relationships with atherosclerosis, lipid levels, and age in three samples from Denmark. 人胰岛素基因5'侧区多态性。丹麦三个样本与动脉粥样硬化、血脂水平和年龄的关系。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-05-01 DOI: 10.1161/01.atv.10.3.372

A Tybjaerg-Hansen, L U Gerdes, K Overgaard, J Ingerslev, O Faergeman, J Nerup

{"title":"Polymorphism in 5' flanking region of human insulin gene. Relationships with atherosclerosis, lipid levels, and age in three samples from Denmark.","authors":"A Tybjaerg-Hansen, L U Gerdes, K Overgaard, J Ingerslev, O Faergeman, J Nerup","doi":"10.1161/01.atv.10.3.372","DOIUrl":"https://doi.org/10.1161/01.atv.10.3.372","url":null,"abstract":"Variations in the DNA sequence flanking the 5' region of the human insulin gene (U- and L-alleles) were studied in relation to atherosclerosis, lipid levels, and age in three groups of atherosclerotic individuals and in nonatherosclerotic controls. The atherosclerotic groups comprised a postmyocardial infarction group with a mean age of 48 years, a group of individuals operated on for carotid stenosis with a mean age of 62 years, and a group of 85-year-olds with clinical coronary disease, peripheral arterial disease, or both. All 331 individuals were unrelated Caucasians of Danish ancestry. There were no significant differences (p greater than 0.05) in genotype distribution or allele frequencies between atherosclerotic and nonatherosclerotic individuals, but in the 85-year-olds, there was evidence (p less than 0.10) for a lower U-allele frequency in nonatherosclerotic women compared to atherosclerotic women. In nonatherosclerotic women, there was a significant decrease in U-allele frequency with age (60 to 85 years). This decrease does not prove conclusively, but is compatible with, the hypothesis that the U-allele predisposes to, or the L-allele protects against, atherosclerosis. The possible effect of the U-allele on the development of atherosclerosis does not seem to be mediated through conventional risk factors.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 3","pages":"372-8"},"PeriodicalIF":0.0,"publicationDate":"1990-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.3.372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13341135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Relationship between sensitivity to dietary fat and dietary cholesterol. 膳食脂肪敏感性与膳食胆固醇的关系。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-05-01 DOI: 10.1161/01.atv.10.3.394

P M Clifton, M Kestin, M Abbey, M Drysdale, P J Nestel

{"title":"Relationship between sensitivity to dietary fat and dietary cholesterol.","authors":"P M Clifton, M Kestin, M Abbey, M Drysdale, P J Nestel","doi":"10.1161/01.atv.10.3.394","DOIUrl":"https://doi.org/10.1161/01.atv.10.3.394","url":null,"abstract":"A group of 56 hypercholesterolemic and normocholesterolemic men and women were given approximately 700 mg a day of egg yolk cholesterol in a double-blind, crossover study while they were on a background diet containing approximately 30% of energy as fat. Overall there was a 0.23 mmol/l rise in plasma cholesterol (3.7%, p less than 0.001) after 4 weeks, a 0.19 mmol/l rise in low density lipoprotein (LDL) cholesterol (4.9%, p = 0.002), and a 0.07 mmol/l rise in high density lipoprotein (HDL) cholesterol (5.4%, p less than 0.001). Plasma triglycerides fell by 0.07 mmol/l (5.1%). Normocholesterolemic individuals (plasma cholesterol less than 5.2 mmol/l) experienced small, nonsignificant rises of 0.06, 0.02, and 0.05 mmol/l in total, LDL, and HDL cholesterol, respectively. Hypercholesterolemic subjects were classified on the basis of their response to a low fat diet. Diet-sensitive subjects were defined by a greater than 10% fall in plasma cholesterol on a 25% fat, low cholesterol (less than 200 mg/day) diet. These individuals were found to be more responsive to the effect of dietary cholesterol than were diet-insensitive subjects; the respective changes in the two groups were rises of 0.36 mmol/l versus 0.19 mmol/l in plasma cholesterol (p = 0.06) and rises of 0.30 versus 0.15 mmol/l in LDL cholesterol (p = 0.06). In addition to elevating HDL cholesterol by 0.09 mmol/l and 0.07 mmol/l, respectively, dietary cholesterol also produced an increase in the proportion of HDL2, from 40% to 44% of HDL protein (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 3","pages":"394-401"},"PeriodicalIF":0.0,"publicationDate":"1990-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.3.394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 71

Species, diet, and gender differences in plasma postheparin lipolytic activities in nonhuman primates. Relationships with plasma lipids and high density lipoproteins. 非人类灵长类动物血浆肝素后溶脂活性的物种、饮食和性别差异。与血脂和高密度脂蛋白的关系。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-05-01 DOI: 10.1161/01.atv.10.3.350

L L Rudel, R J Star

{"title":"Species, diet, and gender differences in plasma postheparin lipolytic activities in nonhuman primates. Relationships with plasma lipids and high density lipoproteins.","authors":"L L Rudel, R J Star","doi":"10.1161/01.atv.10.3.350","DOIUrl":"https://doi.org/10.1161/01.atv.10.3.350","url":null,"abstract":"Studies were done in selected groups of nonhuman primates in which the diet (low fat and high fat as either polyunsaturated or saturated fat), gender, and species (African green monkeys and cynomolgus monkeys) were varied. Large differences in plasma lipid and lipoprotein concentrations were found among these groups, providing the opportunity to examine their relationships to postheparin lipolytic activities (PHLA) including lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL). PHLA was measured in plasma drawn 20 minutes after injection of heparin (100 units/kg). The assay was done with a radioactive triglyceride emulsion, and LPL and HTGL activities were estimated after 1 M NaCl inhibition of the former. LPL activity was high in both species of monkeys, and HTGL activity was low; the ratio of HTGL/LPL was consistently less than 0.5. The mean values for LPL activity did not vary significantly among experimental groups, but significant negative correlations between LPL activity and plasma triglyceride concentration were found. Statistically significant diet, species, and gender differences in HTGL activities were found. In high-fat-fed compared to low-fat-fed animals, HTGL activities were higher, and high density lipoprotein (HDL) cholesterol concentrations and the percentages of HDL2b were also higher. African green monkeys had consistently higher HTGL activities than cynomolgus monkeys and had higher concentrations of HDL cholesterol and a greater proportion of HDL as the larger HDL2b subfraction. Significantly lower HTGL activities were found in females compared to males fed the low-fat diets, and females had a significantly greater proportion of total HDL in the HDL2b subfraction.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 3","pages":"350-7"},"PeriodicalIF":0.0,"publicationDate":"1990-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.3.350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. 氧化特异性脂蛋白加合物和载脂蛋白B在不同严重程度的WHHL兔动脉粥样硬化病变中的分布。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-05-01 DOI: 10.1161/01.atv.10.3.336

M E Rosenfeld, W Palinski, S Ylä-Herttuala, S Butler, J L Witztum

{"title":"Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.","authors":"M E Rosenfeld, W Palinski, S Ylä-Herttuala, S Butler, J L Witztum","doi":"10.1161/01.atv.10.3.336","DOIUrl":"https://doi.org/10.1161/01.atv.10.3.336","url":null,"abstract":"Antisera and monoclonal antibodies generated against autologous malondialdehyde-conjugated low density lipoprotein (MDA-LDL), 4-hydroxynonenal conjugated LDL (4-HNE-LDL), and the protein fragments of apoprotein B resulting from the copper oxidation of LDL, as well as antibodies against apoprotein B, were used to immunostain atherosclerotic lesions of varying severity from Watanabe heritable hyperlipemic rabbits. In macrophage-rich fatty streaks and transitional lesions, all of the antibodies recognizing oxidation specific epitopes exhibited predominantly cell-associated staining in particulate and annular patterns. This is in contrast to the limited, extracellular, diffuse staining obtained with the antibodies recognizing apoprotein B. In more advanced lesions containing areas with reduced numbers of cells, there was increased extracellular, diffuse staining with the antibodies against oxidation specific epitopes and co-localization with apoprotein B. In addition, there were annular staining patterns associated with the necrotic core and increased staining of intimal and medial smooth muscle cells. We interpret these data as suggesting that in areas of lesions rich in macrophages, LDL is oxidized and taken up by the cells. In more advanced lesions that are relatively devoid of macrophages, both native and oxidized LDL, as well as oxidation products released from dead and decaying cells, are trapped in the matrix, out of reach of those cells capable of accumulating oxidized LDL.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 3","pages":"336-49"},"PeriodicalIF":0.0,"publicationDate":"1990-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.3.336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12857644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 478