Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology最新文献

Patch Clamp Technique 膜片钳技术

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 2015-01-01 DOI: 10.1007/springerreference_67425

Hank Loris

引用次数: 0

[Proceedings of the 23rd Annual Meeting of the Japanese Society of Neuropsychopharmacology. September 28-29, 1993. Abstracts]. 日本神经精神药理学学会第23届年会论文集。1993年9月28日至29日。摘要]。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-12-01

引用次数: 0

[Recent advances in neuropharmacology of the centrally acting antitussive drugs]. [中枢作用止咳药的神经药理学研究进展]。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-10-01

J Kamei

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Effects of long-term treatment of haloperidol on D2 dopamine receptors in various areas of rat brain. 氟哌啶醇长期治疗对大鼠脑各区域D2多巴胺受体的影响。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-10-01

M Watanabe, S Ohtakeno, H Watanabe, G Mamiya, N Ichinowatari

引用次数: 0

[Cocaine toxicity, enhancing effects in grouped mice and mechanism on behavioral characteristics]. [可卡因毒性，对小鼠行为特征的增强作用及其机制]。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-10-01

D Houri

{"title":"[Cocaine toxicity, enhancing effects in grouped mice and mechanism on behavioral characteristics].","authors":"D Houri","doi":"","DOIUrl":"","url":null,"abstract":"A marked increase in lethality in grouped mice (group toxicity) following the administration of methamphetamine, a central nervous stimulant, has been well known. Pharmacological effects, behavioral characteristics and toxicities of cocaine are fairly similar to those of methamphetamine. Thus, in this study, the possibility of producing group toxicity induced by cocaine and the participation of biogenic amines and neurotransmitters in the production of behavioral sensitization with cocaine was investigated in ddY male mice. 1) In acute experiment, LD50s of cocaine were not different significantly between control (5 mice) and grouped mice (20 mice), and following continuous administration of cocaine (40 and 50 mg/kg, once a day for 10 days) lethal cases were not observed in control, but mortality was calculated to about 20 and 60% in grouped mice, respectively. 2) The number of deaths was related to environmental condition that mice were restricted. And in the stronger restricted condition, the number of deaths increased. 3) The number of deaths was highly dependent on the environmental temperature and the doses. 4) The repeated administration of cocaine produced the behavioral sensitization in the non-restricted mice but not in the restricted mice. 5) The drugs that changed amines or neurotransmitters inhibited the effects of cocaine in the first administration, but following the repeated administration behavioral sensitization was produced gradually. It is concluded that group toxicity was induced by cocaine. It is also considered that the behavioral sensitization with cocaine was intricately related to many amines or transmitters.","PeriodicalId":77466,"journal":{"name":"Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology","volume":"13 5","pages":"285-94"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18900508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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MK-801 and dopaminergic system in electrically-induced convulsions in mice. MK-801和多巴胺能系统在小鼠电致惊厥中的作用。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-10-01

H Yokoyama, K Onodera, K Iinuma

引用次数: 0

[A study on the pharmacological mechanism of the mood stabilizer--the changes of the rat brain concentrations of monoamines and their metabolites after the administration of Li, CBZ and VPA for 14 days]. [情绪稳定剂药理机制研究——给药14天后大鼠脑内单胺类及其代谢物浓度的变化]。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-10-01

R Ikeda

{"title":"[A study on the pharmacological mechanism of the mood stabilizer--the changes of the rat brain concentrations of monoamines and their metabolites after the administration of Li, CBZ and VPA for 14 days].","authors":"R Ikeda","doi":"","DOIUrl":"","url":null,"abstract":"The concentrations of monoamines and their metabolites (refer to Tables 1 and 2 about each material) in the rat whole brain except for the olfactory bulb and the pituitary gland were measured after the administration of lithium (Li), carbamazepine (CBZ) and valproic acid (VPA) for 14 days. The plasma levels of three drugs were each 0.96 +/- 0.21 mEq/L (Li), 14.216 +/- 3.78 micrograms/ml (CBZ) and 53.341 +/- 31.76 micrograms/ml (VPA). The brain concentrations of monoamines and their metabolites are shown on Tables 1 and 2, and their change rates of the administrated groups to the intact group as control on Figs. 1 and 2. Some changes were similar, i.e. tryptophan, 5-HT, 5-HIAA and L-DOPA seemed to increase, and normetanephrine and 3-MT seemed to decrease in common in three groups. On the contrary, tyrosine, 3-o-methyldopa, DOPAC and HVA increased significantly in only VPA group. It is an uncertain supposition that the common increases or decreases on this study may show the common mechanism among three mood stabilizers, but these changes are very interesting because many reports have mentioned the relation between mood disorder and monoamine neurotransmission. Especially, the common increases of tryptophan, 5-HT and 5-HIAA and the common decreases of 3-MT and normetanephrine may suggest some relation to the pharmacological mechanism of the mood stabilizer.","PeriodicalId":77466,"journal":{"name":"Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology","volume":"13 5","pages":"295-307"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19254161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on daytime sleepiness and psychomotor functions: a comparative double-blind study with diazepam. 坦多螺酮(一种5-HT1A受体相关抗焦虑药)对日间嗜睡和精神运动功能的影响:与地西泮的比较双盲研究

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-08-01

M Suzuki, M Uchiumi, M Murasaki

{"title":"Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on daytime sleepiness and psychomotor functions: a comparative double-blind study with diazepam.","authors":"M Suzuki, M Uchiumi, M Murasaki","doi":"","DOIUrl":"","url":null,"abstract":"A double-blind cross-over placebo-controlled study was designed to compare the effects of a single oral dose of tandospirone (30 mg), a new 5-HT1A receptor-related anxiolytic, on daytime sleepiness, psychomotor function and short-term memory with those of diazepam (5 mg), a benzodiazepine, in 12 healthy Japanese volunteers. A dose of 5 mg of diazepam significantly shortened sleep latencies measured by the Multiple Sleep Latency Test during the periods of 3 to 7 h after the medication, with no influence on the self-estimated sleepiness on the Stanford Sleepiness Scale. The elevated daytime sleepiness under the diazepam treatment was correlated with impaired psychomotor performance; performance on the visual vigilance task significantly declined 1.5 to 3.5 h after the administration of 5 mg of diazepam. In contrast, 30 mg of trandospirone did not impair objective measures of daytime wakefulness or performances. The differential effects of the two anxiolytics on daytime sleepiness and psychomotor functions could be ascribable to the differences in their pharmacological mechanisms of actions. The findings also suggested the superiority of tandospirone to the benzodiazepine in terms of behavioral side effects.","PeriodicalId":77466,"journal":{"name":"Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology","volume":"13 4","pages":"213-24"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18899213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A controlled study of the prophylactic effect of mianserin and placebo in recurrent depression]. [米安色林和安慰剂对复发性抑郁症预防作用的对照研究]。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-08-01

A Kishimoto, R Mizukawa, H Hazama, K Tanaka, H Kamase, N Kunimoto

{"title":"[A controlled study of the prophylactic effect of mianserin and placebo in recurrent depression].","authors":"A Kishimoto, R Mizukawa, H Hazama, K Tanaka, H Kamase, N Kunimoto","doi":"","DOIUrl":"","url":null,"abstract":"To examine the prophylactic effect of mianserin on depressive episode, 26 patients with recurrent depression were randomly allocated on a double-blind basis to treatment with either inactive placebo (PL group) or mianserin in daily dose of 20-60 mg (MIA group) for 18 months and the frequencies or durations of depressive episode during the treatment were compared between the two groups. Except for the 4 patients who dropped out, a comparison of the prophylactic effects of the two groups was performed on 9 patients of the MIA group and 13 patients of the PL group. As a result, recurrence of depressive episode occurred in 4 of 9 patients in the MIA group and in all 13 patients in the PL group during the study. The recurrence rate of the depressive episode during the period in the MIA group was always less than that in the PL group, and significant differences were observed between the two groups from the third to the 18th month of the study. Whereas the frequency and duration of the depressive episode in the MIA group during the period of the study were significantly less than those prior to the study, there was no such difference in the PL group. On the other hand, there was no significant difference in the safety between the two groups. From the result of this study, it was suggested that mianserin is effective in the prophylaxis of depressive episode in patients with recurrent depression.","PeriodicalId":77466,"journal":{"name":"Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology","volume":"13 4","pages":"225-32"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19226401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molecular genetics of aromatic L-amino acid decarboxylase]. [芳香l -氨基酸脱羧酶的分子遗传学]。

Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology Pub Date : 1993-08-01

H Ichinose, T Nagatsu

{"title":"[Molecular genetics of aromatic L-amino acid decarboxylase].","authors":"H Ichinose, T Nagatsu","doi":"","DOIUrl":"","url":null,"abstract":"Aromatic L-amino acid decarboxylase (AADC) decarboxylates both L-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and L-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells. Thus AADC produces two major mammalian neurotransmitters and hormones. We isolated and sequenced a full-length, neuronal-type, cDNA encoding human AADC. It consisted of 1932 bases containing an open reading frame encoding 480 amino acids residues with a molecular weight of 53,891. We expressed a recombinant human AADC in COS cells and proved that the expressed enzyme decarboxylated both L-5-hydroxytryptophan to serotonin and L-dopa to dopamine. We have cloned genomic DNA of human AADC and determined the structure. The genomic DNA of human AADC consists of 15 exons spanning about 100 kilobases and exists as a single copy in the hapoloid genome. We have mapped the gene to chromosome band 7p12.1-p12.3 by fluorescence in situ hybridization. We cloned the nonneuronal type cDNA from human liver and identified another first exon different from the neuronal type cDNA. This showed that an alternative usage of the first exon produced two types of mRNAs in AADC and suggested that alternative splicing would regulate the tissue-specific expression of AADC.","PeriodicalId":77466,"journal":{"name":"Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology","volume":"13 4","pages":"251-6"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19226404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0