West of England medical journal最新文献

Current trends in the management of invasive bladder cancer. 浸润性膀胱癌治疗的最新趋势。

West of England medical journal Pub Date : 1992-12-01

G N Sibley, J Kabala

{"title":"Current trends in the management of invasive bladder cancer.","authors":"G N Sibley, J Kabala","doi":"","DOIUrl":"","url":null,"abstract":"In muscle-invasive bladder cancer, attempts at cure have traditionally involved radical local treatment by either radiotherapy or ablative surgery. However, these treatments have been associated with a high morbidity and have failed to address the problem of subsequent metastatic disease, to which many patients eventually succumb (often within the first 3 years after treatment). Modern imaging techniques have led to much improved staging information, allowing careful selection of patients suitable for radical \"curative\" treatment; at the same time, patients identified as already having metastatic disease may be spared major surgery that is unlikely to influence the outcome of their disease. Reconstructive surgical techniques are beginning to transform the quality of life for patients offered radical surgery, by avoiding the need for traditional urinary diversion. In addition, the use of neo-adjuvant chemotherapy combined with radical local treatment addresses the problem of micrometastases at diagnosis and offers the prospect of improved survival, although the results of clinical trials are awaited to evaluate this further. Future advances in treatment may be expected to occur as our understanding of the biology of bladder cancer increases. Of particular value will be predictive information about the invasive potential of initially superficial tumours, so that these cases may be targeted for \"aggressive\" treatment from the outset.","PeriodicalId":77462,"journal":{"name":"West of England medical journal","volume":"107 3","pages":"67-9"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Oncology 临床肿瘤学

West of England medical journal Pub Date : 1992-12-01 DOI: 10.1007/978-3-642-96472-5

Umberto Veronesi

引用次数: 343

Editorial-The Last Post. 社论-最后一篇文章。

West of England medical journal Pub Date : 1992-12-01

Paul Goddard

引用次数: 0

Incontinence in the elderly. 老年人尿失禁。

West of England medical journal Pub Date : 1992-12-01

G W Tobin

引用次数: 0

Extra pyramidal side effects associated with paroxetine. 帕罗西汀对锥体的额外副作用。

West of England medical journal Pub Date : 1992-12-01

S D Nicholson

引用次数: 0

The role of ultrasound in the management of scrotal disorders. 超声在阴囊疾病治疗中的作用。

West of England medical journal Pub Date : 1992-12-01

J McLoughlin

引用次数: 0

Neuroborreliosis in South Wales. 南威尔士的神经螺旋体病。

West of England medical journal Pub Date : 1992-12-01

K K Lim, B McLean, C J Burns-Cox

引用次数: 0

Editorial: Urology Mini Symposium. 社论:泌尿外科小型研讨会。

West of England medical journal Pub Date : 1992-12-01

Julian Kabala

引用次数: 0

Current trends in the management of localised prostate cancer. 局部前列腺癌治疗的当前趋势。

West of England medical journal Pub Date : 1992-12-01

G N Sibley, J Kabala

{"title":"Current trends in the management of localised prostate cancer.","authors":"G N Sibley, J Kabala","doi":"","DOIUrl":"","url":null,"abstract":"The incidence of prostate cancer in the UK is increasing, and the disease is being detected more often in younger patients (e.g. from routine PSA measurement during health-care screening). Left untreated, a significant proportion of patients will undergo progression of their disease locally and/or develop metastases. Modern imaging techniques have greatly aided the assessment of early prostatic cancer, enabling both accurate assessment of the primary tumour and giving valuable information regarding lymph node metastases. PSA measurements are also extremely helpful, and this has replaced acid phosphatase as a marker for prostatic malignancy. Controversy still remains, however, over the best form of management. Radical prostatectomy undoubtedly produces the best results in the literature, but the patients are highly selected (e.g. those with nodal metastases are excluded) and some patients with well differentiated tumours may have been over-treated, as they may have been expected to do well with surveillance alone. Full clinical trials are required in identically staged patients to assess the relative merits of surveillance, radiotherapy and surgery, and this should now be possible with recent advances in imaging techniques.","PeriodicalId":77462,"journal":{"name":"West of England medical journal","volume":"107 3","pages":"70-2"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational therapy--does the doctor know? 职业疗法，医生知道吗?

West of England medical journal Pub Date : 1992-12-01

E Bawn

引用次数: 0