Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration最新文献_第8页

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2018-11-05 DOI: 10.1080/21678421.2018.1510208

引用次数: 0

Session Subject Index 会议主题索引

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-11-30 DOI: 10.1080/21678421.2017.1368595

引用次数: 0

Poster Contents Page 海报内容页

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-11-30 DOI: 10.1080/21678421.2017.1396412

引用次数: 0

Session Author Index 会话作者索引

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-11-30 DOI: 10.1080/21678421.2017.1368594

引用次数: 0

Poster Subject Index 海报主题索引

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-11-30 DOI: 10.1080/21678421.2017.1374635

引用次数: 0

Poster Author Index 海报作者索引

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-11-30 DOI: 10.1080/21678421.2017.1374623

引用次数: 1

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria. 肌萎缩侧索硬化-额颞谱障碍(ALS-FTSD):修订的诊断标准

IF 2.5 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-05-01 Epub Date: 2017-01-05 DOI: 10.1080/21678421.2016.1267768

Michael J Strong, Sharon Abrahams, Laura H Goldstein, Susan Woolley, Paula Mclaughlin, Julie Snowden, Eneida Mioshi, Angie Roberts-South, Michael Benatar, Tibor HortobáGyi, Jeffrey Rosenfeld, Vincenzo Silani, Paul G Ince, Martin R Turner

{"title":"Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria.","authors":"Michael J Strong, Sharon Abrahams, Laura H Goldstein, Susan Woolley, Paula Mclaughlin, Julie Snowden, Eneida Mioshi, Angie Roberts-South, Michael Benatar, Tibor HortobáGyi, Jeffrey Rosenfeld, Vincenzo Silani, Paul G Ince, Martin R Turner","doi":"10.1080/21678421.2016.1267768","DOIUrl":"10.1080/21678421.2016.1267768","url":null,"abstract":"<p><p>This article presents the revised consensus criteria for the diagnosis of frontotemporal dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research workshop on frontotemporal dementia (FTD) and ALS held in London, Canada in June 2015. Since the publication of the Strong criteria, there have been considerable advances in the understanding of the neuropsychological profile of patients with ALS. Not only is the breadth and depth of neuropsychological findings broader than previously recognised - - including deficits in social cognition and language - but mixed deficits may also occur. Evidence now shows that the neuropsychological deficits in ALS are extremely heterogeneous, affecting over 50% of persons with ALS. When present, these deficits significantly and adversely impact patient survival. It is the recognition of this clinical heterogeneity in association with neuroimaging, genetic and neuropathological advances that has led to the current re-conceptualisation that neuropsychological deficits in ALS fall along a spectrum. These revised consensus criteria expand upon those of 2009 and embrace the concept of the frontotemporal spectrum disorder of ALS (ALS-FTSD).</p>","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":"18 1","pages":"153-174"},"PeriodicalIF":2.5,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47755142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slowly progressive motor neuron disease with multi-system involvement related to p.E121G SOD1 mutation 与p.E121G SOD1突变相关的多系统累及的缓慢进行性运动神经元疾病

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-04-03 DOI: 10.1080/21678421.2016.1255756

G. Taieb, A. Polge, R. Juntas-Morales, N. Pageot, S. Lumbroso, K. Mouzat, W. Camu

引用次数: 1

Assessing cognitive functioning in ALS: A focus on frontal lobe processes 评估ALS患者的认知功能:对额叶过程的关注

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-04-03 DOI: 10.1080/21678421.2016.1248977

S. Gillingham, Y. Yunusova, A. Ganda, E. Rogaeva, S. Black, D. Stuss, L. Zinman

{"title":"Assessing cognitive functioning in ALS: A focus on frontal lobe processes","authors":"S. Gillingham, Y. Yunusova, A. Ganda, E. Rogaeva, S. Black, D. Stuss, L. Zinman","doi":"10.1080/21678421.2016.1248977","DOIUrl":"https://doi.org/10.1080/21678421.2016.1248977","url":null,"abstract":"Abstract Objective: It is generally acknowledged that at least 50% of individuals with amyotrophic lateral sclerosis (ALS) will exhibit cognitive deficits outside of the characteristic motor neuron involvement. However, a specific cognitive profile has been difficult to ascertain due to disease-related testing barriers and limitations in the sensitivity and specificity of available assessment methods. This study assessed the level of functioning of extramotor frontal cognitive processes in ALS, and the amount of change in the functioning in these processes over time as disease progresses. Methods: Empirical tests validated for a model of frontal lobe functioning were modified into an assessment battery appropriate for individuals with ALS in a clinical setting (the ALS-CFB, Computerised Frontal Battery). Twenty ALS participants and 36 age- and education-matched neurologically healthy controls were tested, and a sub-sample of each group (11 ALS and 20 controls) re-tested after approximately nine months. Results and conclusions: Compared to standard neuropsychological screening tests that did not show a difference between ALS participants and healthy controls, the ALS-CFB illustrated a profile of extramotor frontal dysfunction involving energisation (preparing the neural system to respond) and executive functions, a profile that may be indicative of the nature of neurodegeneration in ALS.","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":"18 1","pages":"182 - 192"},"PeriodicalIF":2.8,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21678421.2016.1248977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44184416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Geographic distributions of motor neuron disease mortality and well water use in U.S. counties 美国各县运动神经元疾病死亡率和井水使用的地理分布

IF 2.8 4区医学

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2017-04-03 DOI: 10.1080/21678421.2016.1264975

G. Schwartz, B. Rundquist, Isaac J. Simon, S. Swartz

{"title":"Geographic distributions of motor neuron disease mortality and well water use in U.S. counties","authors":"G. Schwartz, B. Rundquist, Isaac J. Simon, S. Swartz","doi":"10.1080/21678421.2016.1264975","DOIUrl":"https://doi.org/10.1080/21678421.2016.1264975","url":null,"abstract":"Abstract Objective: We recently reported that U.S. mortality rates for motor neuron disease (MND) at the level of the state are associated with well water use. However, data at the state level may not accurately reflect data at the individual level. We therefore examined the association between MND mortality and well water use utilizing data from smaller geographic units that may better reflect exposure and disease at the individual level. Methods: We used data on age-adjusted MND mortality rates at the level of the county, obtained from the CDC, and corresponding data on the prevalence of well water use, obtained from the U.S. Geological Survey. Data were analyzed by multivariate linear regression and by Getis-Ord Gi*, a measure of spatial clustering. Results: Age-adjusted mortality rates for MND in 923 U.S. counties were significantly correlated with the prevalence of well water (p < 0.0001). ‘Hot spots’ of MND mortality were significantly associated with ‘hot spots’ of well water use (p < 0.0005). Conclusions: These findings support the hypothesis that an agent present in well water plays an etiologic role in ALS. Further study of water use among individuals with ALS is warranted.","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":"18 1","pages":"279 - 283"},"PeriodicalIF":2.8,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21678421.2016.1264975","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42705344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14