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Seminars in dermatology最新文献

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Review of investigative diagnostic techniques for cutaneous lymphoma. 皮肤淋巴瘤的调查诊断技术综述。
Seminars in dermatology Pub Date : 1994-09-01
D N Slater
{"title":"Review of investigative diagnostic techniques for cutaneous lymphoma.","authors":"D N Slater","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article reviews the contribution of modern investigative techniques to the diagnosis of cutaneous lymphoproliferative diseases. Special attention is given to the significance of immunoglobulin and T-cell receptor rearrangements; as detected by Southern blotting and/or the polymerase chain reaction. Additional topics discussed include immunohistochemistry, cytogenetics, onco- and tumour suppressor genes and in-situ hybridization. It is recommended that the results of these techniques are interpreted in the form of a multifaceted diagnostic profile.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"166-71"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18985591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical, histopathologic, and immunohistochemical correlations in leukemia cutis. 皮肤白血病的临床、组织病理学和免疫组织化学相关性。
Seminars in dermatology Pub Date : 1994-09-01
W P Su
{"title":"Clinical, histopathologic, and immunohistochemical correlations in leukemia cutis.","authors":"W P Su","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Specific (leukemia cutis) and nonspecific (reactive or secondary) skin lesions are associated with systemic leukemia. The following categories of leukemia cutis are discussed in this article: myelogenous (granulocytic) leukemia, monocytic leukemia, myelomonocytic leukemia, lymphocytic and lymphoblastic leukemia, hairy cell leukemia, and adult T-cell leukemia/lymphoma. The temporal relationship between the diagnoses of systemic leukemia and leukemia cutis, the course, and the prognosis are also discussed. Other sites of extramedullary involvement are correlated with leukemia cutis. The appearance of specific skin lesions in leukemia is usually associated with a very poor prognosis.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"223-30"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphomatoid papulosis: a follow-up study of 41 patients. 淋巴样丘疹病:41例患者的随访研究。
Seminars in dermatology Pub Date : 1994-09-01
H K Christensen, K Thomsen, G L Vejlsgaard
{"title":"Lymphomatoid papulosis: a follow-up study of 41 patients.","authors":"H K Christensen,&nbsp;K Thomsen,&nbsp;G L Vejlsgaard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Forty-one patients with lymphomatoid papulosis have been followed from 1 to 22 years (mean 11.4 years, median 10 years). Six patients developed malignant lymphoma, 3 cutaneous T-cell lymphoma, 2 Ki-1 large cell lymphoma, and 1 Hodgkin's disease. A clinical malignant presentation combined with the finding of aneuploidy in skin lesions seem to be indications of a malignant potential. Treatment with methotrexate in low dosage is an efficient treatment of lymphomatoid papulosis and probably diminishes the risk of malignancy.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of human T-cell lymphotropic viruses (HTLV-I and II) in cutaneous T-cell lymphomas. 人t细胞嗜淋巴病毒(HTLV-I和htlv - II)在皮肤t细胞淋巴瘤中的作用。
Seminars in dermatology Pub Date : 1994-09-01
D Zucker-Franklin, B A Pancake
{"title":"The role of human T-cell lymphotropic viruses (HTLV-I and II) in cutaneous T-cell lymphomas.","authors":"D Zucker-Franklin,&nbsp;B A Pancake","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although an association between the human T cell lymphotropic viruses (HTLV-I and II) and cutaneous T cell lymphoma (CTCL) has long been suspected, only a minor fraction of patients with this disease have antibodies to the viral structural proteins. However, the consistent finding of HTLV-like particles in cultures of peripheral blood mononuclear cells (PBMC) from such patients has prompted a continued effort to find evidence linking the virus to this disease. Capitalizing on the increased sensitivity afforded by combining PCR amplification with detection by Southern blot hybridization, it became possible to demonstrate HTLV tax and/or pol proviral sequences in freshly isolated PBMC of most patients with mycosis fungoides. These observations suggest a possible role of the virus in the pathogenesis of CTCL, and may impact on diagnostic and therapeutic measures in the future.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"160-5"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18985590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD30+ anaplastic large cell lymphomas. CD30+间变性大细胞淋巴瘤。
Seminars in dermatology Pub Date : 1994-09-01
P Kaudewitz, P Kind, C A Sander
{"title":"CD30+ anaplastic large cell lymphomas.","authors":"P Kaudewitz,&nbsp;P Kind,&nbsp;C A Sander","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Within the spectrum of CD30+ lymphoproliferative diseases of the skin primary cutaneous CD30+ large cell lymphomas are now recognized as a distinct clinicopathologic entity. Once terminologic confusions are clarified the pertinent clinical, histomorphological, and immunophenotypical features essential for the diagnosis can be delineated. Clinical studies indicate a better prognosis of primary cutaneous CD30+ large cell lymphomas as compared with their nodal counterparts and with other cutaneous large cell lymphomas. Therapeutic strategies should be planned accordingly.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"180-6"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of cutaneous T-cell lymphoma. 皮肤t细胞淋巴瘤的治疗。
Seminars in dermatology Pub Date : 1994-09-01
H S Zackheim
{"title":"Treatment of cutaneous T-cell lymphoma.","authors":"H S Zackheim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A review of current therapy for cutaneous T-cell lymphoma (CTCL) (mycosis fungoides and erythrodermic CTCL) is presented. Treatments for mycosis fungoides limited to the skin include topical steroids, mechlorethamine (nitrogen mustard) and carmustine (BCNU), electron beam radiation, low-dose methotrexate, and interferon-alpha (IFN). Treatments for erythrodermic CTCL include low-dose methotrexate, IFN, extracorporeal photopheresis, and single agent or combination chemotherapy. Treatment for systemic CTCL includes IFN, single or combination chemotherapy, and combined modalities. Newer therapies are reviewed. Whereas prognosis for patients with disease limited to the skin is generally good, that for those with nodal or visceral lymphoma is mostly unfavorable. Controversial issues relating to total skin versus local treatment, prolonged maintenance versus intermittent therapy, and aggressive versus conservative treatment of early stage disease are discussed. The UCSF approach to treatment of CTCL and lymphomatoid papulosis is presented.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"207-15"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous pseudolymphomas: classification and differential diagnosis. 皮肤假性淋巴瘤:分类与鉴别诊断。
Seminars in dermatology Pub Date : 1994-09-01
J U Rijlaarsdam, R Willemze
{"title":"Cutaneous pseudolymphomas: classification and differential diagnosis.","authors":"J U Rijlaarsdam,&nbsp;R Willemze","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cutaneous pseudolymphomas are benign hyperplastic lymphoproliferative reactions that simulate cutaneous malignant lymphomas clinically and/or histologically. The differentiation between cutaneous pseudolymphomas and primary cutaneous lymphomas is often very difficult, but is important because it has therapeutic consequences. The term pseudolymphoma does not refer to a specific disease, but to a heterogeneous group of pseudo-B-cell lymphomas and pseudo-T-cell lymphomas. In this article clinical and histological features of this group of disorders will be discussed and the differential diagnostic criteria, that have been used in the past decades to differentiate between cutaneous lymphomas and pseudolymphomas will be critically evaluated.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"187-96"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study of cutaneous T-cell lymphoma and adult T-cell leukemia/lymphoma. 皮肤t细胞淋巴瘤与成人t细胞白血病/淋巴瘤的比较研究。
Seminars in dermatology Pub Date : 1994-09-01
T Nagatani, M Miyazawa, T Matsuzaki, G Iemoto, S T Kim, N Baba, H Miyamoto, H Nakajima
{"title":"Comparative study of cutaneous T-cell lymphoma and adult T-cell leukemia/lymphoma.","authors":"T Nagatani,&nbsp;M Miyazawa,&nbsp;T Matsuzaki,&nbsp;G Iemoto,&nbsp;S T Kim,&nbsp;N Baba,&nbsp;H Miyamoto,&nbsp;H Nakajima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An important disease entity distinct from cutaneous T-cell lymphoma (CTCL) in Japan is adult T-cell leukemia/lymphoma (ATL), which shows almost the same phenotype as CTCL, ie, a helper/inducer T-cell phenotype (CD4-positive, CD8-negative), and usually involves the skin. This article describes differences between CTCL and ATL in terms of clinical and immunopathologic cell surface features. In patients with ATL, the predominant physical findings were lymph node, bone marrow and skin involvement, hepatosplenomegaly, leukemic manifestations, and an aggressive course. In patients with CTCL, in contrast, only skin lesions predominated at the onset of the disease and a relatively good prognosis was shown. The predominant phenotype of the neoplastic cells in the skin of patients with CTCL was CD3+, CD4+, CD29+, CD45RO+, HLA-DR+, HLA-DQ+, CD7-, L-selectin-, and CD45RA-. Some phenotypic discrepancy was found between the neoplastic cells in the peripheral blood, lymph nodes and skin of patients with ATL with respect to CD45RA and CD45RO, and CD7, CD29, CD25, and HLA-DR. That is, the predominant neoplastic cell phenotype was helper T-cell, which was CD3+, CD4+, L-selectin+, CD25+, CD45RA+, HLA-DR+, CD29-, and CD45RO- in peripheral blood, and CD3+, CD4+, L-selectin+, CD29+, CD45RO+, HLA-DR+, and CD45RA- in the skin and lymph nodes. Phenotypic heterogeneity of ATL cells and heterogeneity of CD45R isoform expression on ATL cells were evident in different organs. These findings confirm that the difference in antigen expression on the cell surface might reflect the clinical features of ATL and CTCL. CTCL cells do not share the same phenotype as ATL cells.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"216-22"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical carmustine (BCNU) for patch/plaque mycosis fungoides. 局部卡莫司汀(BCNU)治疗斑块/菌斑真菌病。
Seminars in dermatology Pub Date : 1994-09-01
H S Zackheim
{"title":"Topical carmustine (BCNU) for patch/plaque mycosis fungoides.","authors":"H S Zackheim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article summarizes experience with topical carmustine (BCNU) solution in 172 patients with patch/plaque stage mycosis fungoides. At 36 months 92% of stage-T1 (less than 10% skin involvement) and 64% of stage-T2 (10% or more skin involvement) patients were either in complete or partial remission. The most frequent side effect was an erythematous reaction which was followed by a benign-type telangiectasia in some patients. No secondary skin cancers were seen. Bone marrow depression was uncommon. Topical BCNU is an effective treatment for patch/plaque stage mycosis fungoides.</p>","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"202-6"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18981563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous lymphomas other than mycosis fungoides. 非蕈样真菌病的皮肤淋巴瘤。
Seminars in dermatology Pub Date : 1994-09-01
P Joly, E Thomine, P Lauret
{"title":"Cutaneous lymphomas other than mycosis fungoides.","authors":"P Joly,&nbsp;E Thomine,&nbsp;P Lauret","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77387,"journal":{"name":"Seminars in dermatology","volume":"13 3","pages":"172-9"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18985592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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