{"title":"Pulmonary Langerhans' cell granulomatosis (LCG).","authors":"W J Williams, D G James","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pulmonary Langerhans' granulomatosis (LCG) is characterised by infiltration of peripheral airways by dendritic cell precursors and Langerhans' cells (LC) together with eosinophils and mixed chronic inflammatory cells. Consequent airways destruction commonly leads to cystic changes and frequent pneumothorax. LC's are best identified by the electron microscope finding of Birbeck granules. Immunocytochemical markers are also of value. They are frequent in the early stages though absent in end stage disease. LCG is distinguished from sarcoidosis by the absence of epithelioid cell granulomas, association with heavy cigarette smoking in young males and frequency of pneumothorax. Both diseases show lymphocytosis in bronchoalveolar lavage but differ in that LCG shows a predominance of T-suppressor cells and sarcoidosis an excess of T-helper cells.</p>","PeriodicalId":77376,"journal":{"name":"Sarcoidosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19133150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sarcoidosis--the way ahead.","authors":"D G Jones","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cause(s) of sarcoidosis is likely to be a combination of a conducive soil or sarcoid diathesis invaded by an antigen-driven cell-mediated immune response. The antigenic invasion may be mycobacteria and other organisms and/or their chemical constituents. A ten-point plan of management is set out so that early diagnosis allows early treatment and to prevent complicating pulmonary, ocular or renal fibrosis and to prevent failure of these vital organs.</p>","PeriodicalId":77376,"journal":{"name":"Sarcoidosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19131678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Luisetti, M Martinetti, M Cuccia, L Pasturenzi, A Cipriani, G Semenzato, C Grassi
{"title":"HLA Class I, II and III polymorphisms in sarcoidosis.","authors":"M Luisetti, M Martinetti, M Cuccia, L Pasturenzi, A Cipriani, G Semenzato, C Grassi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77376,"journal":{"name":"Sarcoidosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19132316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Cerutti, L Trentin, R Zambello, P Bulian, A Milani, C Enthammer, R Sancetta, A Cipriani, C Agostini, G Sememzato
{"title":"Selection of Valpha 2.3 cells in the lung of patients with sarcoidosis.","authors":"A Cerutti, L Trentin, R Zambello, P Bulian, A Milani, C Enthammer, R Sancetta, A Cipriani, C Agostini, G Sememzato","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77376,"journal":{"name":"Sarcoidosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19132328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of magnetic resonance imaging in neurosarcoidosis.","authors":"J K Kadakia, P M Collette, O P Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central nervous system (CNS) involvement in Sarcoidosis poses a difficult diagnostic problem for the clinician. Neurologic involvement may occur long before the onset of symptoms. Contrast enhanced computerized tomography does not always reveal parenchymal and meningeal involvement. Recently gadolinium enhanced Magnetic Resonance Imaging has shown increased sensitivity in detecting CNS involvement. These findings however are not specific for sarcoidosis and one must consider appropriate clinical circumstances in arriving at the diagnosis.</p>","PeriodicalId":77376,"journal":{"name":"Sarcoidosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19132334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}