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Romanian journal of endocrinology最新文献

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Chemical carcinogenesis as a factor altering the tissue ability to bind hormones. Benzo(a)pyrene--insulin interrelationship. 化学致癌是改变组织结合激素能力的一个因素。苯并(a)芘——胰岛素的相互关系。
Romanian journal of endocrinology Pub Date : 1993-01-01
C T Dragomir, S Botea, D Mihalache, R Chirvasie, M Mocanu
{"title":"Chemical carcinogenesis as a factor altering the tissue ability to bind hormones. Benzo(a)pyrene--insulin interrelationship.","authors":"C T Dragomir,&nbsp;S Botea,&nbsp;D Mihalache,&nbsp;R Chirvasie,&nbsp;M Mocanu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study was carried out on the uptake of 125I-insulin in the tissues or organs (liver, subcutaneous adipose tissue, striated muscle, renal cortex, frontal lobes of the brain) of normal Wistar rats or from animals treated with benzo(a)pyrene, a powerful carcinogen which s metabolically activated in the liver. The carcinogen was administered as follows: (a) in adult life by a single injected dose; (b) in early fetal life by administration to pregnant females and (c) in late fetal life, likewise by administration to the mothers. The results of combined administrations were studied as well. The ability of normal tissues to take up insulin was determined. The administration of a single benzo(a)pyrene dose produced marked alterations in binding of the hormone in some of the tissues, which might be attributed to certain general changes in the properties of the cell membranes. It has to be underlined that after the contact with the carcinogen in fetal life, the tissular ability to take up insulin is irreversibly and non-uniformly altered. This ability is easily influenced by a new carcinogenic dose.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 1-2","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative and antioxidative factors in the serum of thyroid cancer patients treated with 131I. 131I治疗甲状腺癌患者血清氧化及抗氧化因子的变化。
Romanian journal of endocrinology Pub Date : 1993-01-01
R Bartoc, C Dumitrescu, M Belgun, R Olinescu
{"title":"Oxidative and antioxidative factors in the serum of thyroid cancer patients treated with 131I.","authors":"R Bartoc,&nbsp;C Dumitrescu,&nbsp;M Belgun,&nbsp;R Olinescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The variation of some parameters involved in maintaining the balance between pro- and anti-oxidative factors was followed-up in a group of patients thyroidectomized for folliculo-papillary, papillary and follicular cancer, before and after 5 days following the 131I administration. Radiotherapy led to the intensification of lipid peroxidation expressed by a significant increase in the malondialdehyde values. Among the parameters involved in the antioxidative process we noted an increase in both SH nonprotein groups and ceruloplasmin concentration. The total antioxidative capacity lowered significantly following irradiation, whereas uric acid remained unaltered.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 1-2","pages":"85-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the hypothalamic paraventricular nucleus upon the activity of thyroid and adrenal glands and their relation with body defense function. 下丘脑室旁核对甲状腺和肾上腺活动的作用及其与机体防御功能的关系。
Romanian journal of endocrinology Pub Date : 1993-01-01
V P Hefco, A Olariu, A Petraşcu, A Robu
{"title":"The role of the hypothalamic paraventricular nucleus upon the activity of thyroid and adrenal glands and their relation with body defense function.","authors":"V P Hefco,&nbsp;A Olariu,&nbsp;A Petraşcu,&nbsp;A Robu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lesion of the PVH or its isolation--either alone or together with the medial hypothalamus, at fronto-lateral or complete level, induces a significant decrease in plasma thyroxine and a negligible modification of triiodothyronine. Variations recorded with various groups, having the medial hypothalamus deconnected, suggest that the main thyroliberin secreting (TRH) region is located at the level of PVH. Immunization of animals restores the thyroid function in the animals with damaged PVH, under the action of thyrotropin (TSH) of lymphocyte origin. Although the main CRH source occurs at the level of PVH, the results obtained after lesions or isolations of the hypophysotropic region demonstrate the extended distribution of CRH within various nervous areas, and its possible involvement in maintaining the adrenal gland function.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 3-4","pages":"133-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18699523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasotocin effects in depressive patients with eating disorders. 饮食失调抑郁症患者的血管催产素效应。
Romanian journal of endocrinology Pub Date : 1993-01-01
O Joja, R Goldstein, M Popa
{"title":"Vasotocin effects in depressive patients with eating disorders.","authors":"O Joja,&nbsp;R Goldstein,&nbsp;M Popa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since arginine vasotocin (AVT) effects are mediated by serotonin, which was involved in the production of eating disorders, disorders which show many common mechanisms with the depressive disorders, and since AVT was used as treatment of depressive disorders, we investigated the AVT effects in a double-blind study with patients with eating disorders. We compared AVT effects on 15 patients with eating disorders to 18 patients with eating disorders which received tricyclic antidepressants or cognitive-behavioral psychotherapy. The severity of depression was assessed by means of the Hamilton Depression Scale and of Beck's Depression Inventory, before and after three months therapy. Data showed a significant improvement of depressive symptomatology after AVT treatment. Comparison of AVT effects on depression of eating disorders subgroups versus tricyclic antidepressant or psychotherapy treatment are discussed.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 3-4","pages":"171-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18699526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of hyperthyroidism due to Graves' disease: a retrospective analysis of 1,000 inpatient cards. 格雷夫斯病所致甲状腺功能亢进的治疗:1000张住院卡的回顾性分析
Romanian journal of endocrinology Pub Date : 1993-01-01
M Simescu, E Balmes, H I Ursu, G Voiculescu, S Popa
{"title":"Management of hyperthyroidism due to Graves' disease: a retrospective analysis of 1,000 inpatient cards.","authors":"M Simescu,&nbsp;E Balmes,&nbsp;H I Ursu,&nbsp;G Voiculescu,&nbsp;S Popa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There are three different modalities to treat hyperthyroidism due to Grave's disease: anti-thyroid drugs (ATD), radioiodine and surgery, each of them having its own advantages and disadvantages. The option for one of the three therapeutical approaches has both subjective and objective components. In Europe, a screening on the therapeutical options in Graves' disease was performed at the European Thyroid Association (ETA) initiative, being based on a questionnaire. In the Thyroid Department of the Endocrinology Institute in Bucharest, w analysed the managements of hyperthyroidism due to Graves' disease on 1,000 cards of hyperthyroid patients admitted there during the last five years. In order to diagnose Graves' disease, in vivo tests radioiodine uptake (RIU) at 2 and 24 hrs, 93.39% scintigram (92.93%), thyroid ultrasonography (15%) and reflexogram (98.06%), were carried out. Out of the in vitro tests, PBI (protein bound iodine) was performed prioritarily, while T4, T3 (variable), TSH (13.91%) were performed according to the economic factors. For the patient with moderate hyperthyroidism, antithyroid therapy was alternative with the radioiodine one (51.61% and 48.35%, respectively). The age of the patient played a major role in the decision to take. The frequency of cases treated with radioiodine was considerably higher in the patients with recurrence and in the elderly. The initial dose of antithyroid treatment was high (50-60 mg), and was reduced according to the thyroid function. The therapy duration was not pre-determined. The ATD treatment was prolonged for a time-interval ranging between 2 and 5 years, depending of the clinical status (age, sex, goiter size, exophthalmic syndrome) and the social conditions.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 3-4","pages":"97-105"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18699529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternatives in human reproduction. Methods, indications, prognosis, bioethical problems. 人类生殖的替代品。方法，适应症，预后，生物伦理问题。
Romanian journal of endocrinology Pub Date : 1993-01-01
C Dumitrache, R Drăghia
{"title":"Alternatives in human reproduction. Methods, indications, prognosis, bioethical problems.","authors":"C Dumitrache,&nbsp;R Drăghia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The alternative methods in human reproduction do nothing else than try to help an individual or a couple to achieve the primordial goal of life: perpetuation of the species. These methods try to reconstruct the biologic premises necessary for perpetuation by various means such as: a. in vitro fecundation correlated or not with artificial fecundation with donor, ovocyte donation, embryo donation, borrowed mother; b. intratubular transfer of gametes; c. unnatural circumstances, i.e., the possibility that men be a host for the embryo up to term, a hypothesis which for the time being is possible only in science-fiction. The birth of Louisa Brown in 1978 was the border between hope and certainty, between dream and pragmatism. Thus, the alternative methods of reproduction have become routine in the medical life and penetrated into the conscience of an ever greater number of people but at the same time have raised an immense number of questions regarding the status of the embryo and the foetus, but more important, of the child born under these circumstances. These questions await answers both from medicine and the law and have to be within the limits of the common sense. Those who participate in the in vitro fecundation programs should not lose their quality of being human, should pay respect to the nature and the natural, encourage hope and be moral.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 1-2","pages":"5-22"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of catecholamines in the distribution of steroid hormones in the striated and cardiac muscle. 儿茶酚胺在横纹肌和心肌中类固醇激素分布中的作用。
Romanian journal of endocrinology Pub Date : 1993-01-01
C Burtea, A David, F Butnaru
{"title":"The role of catecholamines in the distribution of steroid hormones in the striated and cardiac muscle.","authors":"C Burtea,&nbsp;A David,&nbsp;F Butnaru","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Loss of muscular strength is a well-known component of the clinical picture many endocrine diseases and is often their predominant aspect. It has recently been proved that the cytoplasmatic receptors for steroid hormones (SH) are artefacts of the fixation techniques and that they are attached to the internal surface of the cell membrane. Our experiment was made on male and female. Wistar rats which were tested for the level of radioactively labelled steroid hormones (3H and HD3H hydrocortisone; 3H testosterone, TS3H; 3H estrone, FS3H) in various types of skeletal muscles (from rapid to slow) and cardiac muscle before and after adrenalin administration. Before adrenalin administration one noticed: (a) a significantly higher level of HD3H (p < 0.05) in the female skeletal muscle; (b) in the femoral biceps and psoas, a significantly higher distribution of TS3H in males (p < 0.01), whereas in the diaphragm and the heart, there were no significant differences between sexes; (c) there are significant differences between sexes as regards the ES3H level in any of the studied muscles. After adrenalin administration there was a significant decrease in the level of labelled SH uptake in all experimental schemes. It is possible that adrenalin block the HS diffusion through the plasma membrane or even their binding to specific receptors.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 1-2","pages":"41-8"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19164869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth hormone and prolactin levels in stress-induced food intake dysregulation. 应激诱导的食物摄入失调中的生长激素和催乳素水平。
Romanian journal of endocrinology Pub Date : 1993-01-01
G Gnacinska
{"title":"Growth hormone and prolactin levels in stress-induced food intake dysregulation.","authors":"G Gnacinska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hormonal mechanism involved in stress-induced dysregulation of feeding behaviour is not known. In this study anterior pituitary hormones: GH and prolactin/PRL were analyzed, immediately and 60 min. after 1 hr immobilization stress, in rats with enhanced or with diminished food intake. The results show, in rats with diminished food intake after stress, a fall in GH level from 3.9 mU/l to 2.3 mU/l upon exposure and 1.5 mU/l 60 min. after stress. The PRL level elevated to 26.0 mU/l upon exposure to stress in comparison to 9.6 mU/l in the control group, and reached near normal values after 60 min. In rats with enhanced food intake after stress, the GH and PRL levels did not change immediately after stress. Sixty minutes after stress a fall in GH level to 2.4 mU/l was noted, and an elevation of PRL level to 21.9 mU/l. So the change in levels of pituitary hormones in these rats were slower and less pronounced than in rats with suppressed food intake.</p>","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 3-4","pages":"107-13"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A point of view on the classification of the etiopathogenic forms of thyroid failure. 甲状腺功能衰竭的病因形式分类的观点。
Romanian journal of endocrinology Pub Date : 1993-01-01
C Dumitrache, C Poiană
{"title":"A point of view on the classification of the etiopathogenic forms of thyroid failure.","authors":"C Dumitrache,&nbsp;C Poiană","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 3-4","pages":"179-87"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18699527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification of the etiopathogenic forms of thyreotoxicosis. A point of view. 甲状腺中毒的病因分类。一种观点。
Romanian journal of endocrinology Pub Date : 1993-01-01
C Dumitrache, C Poiană, R Drăghia
{"title":"Classification of the etiopathogenic forms of thyreotoxicosis. A point of view.","authors":"C Dumitrache,&nbsp;C Poiană,&nbsp;R Drăghia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77369,"journal":{"name":"Romanian journal of endocrinology","volume":"31 3-4","pages":"189-98"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18699528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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