{"title":"The MSH-like activity of pineal hormone E5 in vivo and in vitro experiment.","authors":"C Neacşu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Further experiments have revealed that the polypeptidic hormone E5 has a MSK-like effect, as experimentally demonstrated on the frog skin. In Rana esculenta, 30-120 min after a subcutaneous injection of 0.2 mg purified E5B or E5P/100 g b.w., the skin blackened and the effect lasted for about two hours. A comparable effect was induced by incubating the fragment of frog abdominal skin with a similar solution of E5. This MSK-like effect appears to be identical upon mammalian melanocytes in C57/B16 mice strain valves in vitro experiment. The results obtained indicate that pineal gland can influence melanocyte activity directly and suggest the possible implication in such pathological conditions as melanomas, vitiligo, etc.</p>","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 3-4","pages":"83-5"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Baltă, M Constantinescu, A Popa-Mare, M Petec, D L Dumitraşcu, C Cernescu
{"title":"[Etiopathogenesis of chronic liver diseases detected and evaluated using immunologic tests].","authors":"N Baltă, M Constantinescu, A Popa-Mare, M Petec, D L Dumitraşcu, C Cernescu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 3-4","pages":"129-36"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Irrigation of the extremities in young people with Raynaud's syndrome].","authors":"S Gusti, I Stoicescu, A Gusti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 3-4","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The development of applied physiology in Cluj.","authors":"P Derevenco","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 1-2","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12643232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contributions of the Cluj physiology school to the study of capillary permeability for macromolecules.","authors":"L Grosu, E Rosenfeld","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 1-2","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12643234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of nervous mechanisms in the immune response.","authors":"I Baciu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review presents the results of experimental researches performed in the last decades by Cluj-Napoca physiologists, concerning the role of hypothalamic nervous centers in the triggering of the nonspecific (phagocytic reaction) and specific (primary and secondary) immune response. The following methods aiming to explore the involvement of the hypothalamic vegetative nervous centers have been applied: section of the spinal cord, somatoencephalic humoral isolation with preservation of spinal cord, stimulation or lesions under stereotaxic control of some hypothalamic areas, conditioned reflexes, electroconvulsant shocks. The results show that nervous centers from the tuberal area and from the posterior hypothalamus are involved in the regulation and integration of the immune response considered as a homeostatic function, in connexion with a preoptic, anterior and lateral hypothalamic area, with a receptive function to antigens and their endogenous products. The activation of phagocytosis (phagocytic response) can be elicited in dogs by electrical stimulation of the tuberal area and inhibited by section of the spinal cord, or by barbiturates. The specific immune response is moderately neuromodulated for antigens, as heterospecific red cells and more intensely for Salmonella and especially for the influenza virus. These results could allow an integration of other analytical data of cellular and molecular biology of immunity wider functional concept.</p>","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 1-2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12642459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of platelets and leukocytes in coagulation and fibrinolysis.","authors":"M Cucuianu, I Trif","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After briefly reviewing the literature concerning the role of leukocytes and platelets in coagulation and fibrinolysis, the authors present their own results on the effect of intact platelets and of platelet releasate on tissue plasminogen activator-induced lysis of plasma clots. At a final concentration of 7 IU/ml of tissue plasminogen activator in the clotted mixture, a suspension of intact platelets (110 x 10(6)/ml in final concentration) produced an acceleration of clot lysis, while the thrombin-induced platelet releasate obtained from the same platelet suspension caused an obvious inhibition of fibrinolysis. The respective mean lysis times obtained in 7 experiments were 91 min +/- 7.76 (mean +/- SEM) for the control clots, 65 min +/- 5.8 for the clots containing platelets and 114 min +/- 11.5 for the clots including platelet releasate. The statistical significance versus controls, calculated by paired difference analysis was p < 0.002 and p < 0.001, respectively. The results suggest that in the context of a potent activation of fibrinolysis the platelet surface would enhance the process by favouring the interaction between plasminogen and its activator, while the platelet releasate rich inhibitors would increase the resistance to lysis of the plasma clot.</p>","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 1-2","pages":"33-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12643235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The control of erythropoiesis (Romanian contributions).","authors":"M Dorofteiu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The main contributions of a Romanian team, headed by I. Baciu, in the field of the control of erythropoiesis are presented. The role of the central nervous system in the regulation of erythrocytes production and the identification of chemoreceptors sensitive to hypoxia in the central nervous system are disclosed. The studies concerning the secretion and the effects of erythropoietin are also emphasized. The paper provided references to the recent data concerning the structure of erythropoietin, the membrane receptors, the metabolism and the practical applications of the hormone.</p>","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 1-2","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12643230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychoneuroimmunology.","authors":"A Baban","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The recent findings on the close relation between the nervous and immune systems have led to the developing of a new interdisciplinary field: psychoneuroimmunology. This review outlines the topic of the research, the limits and the future trends of psychoneuroimmunology, emphasizing the reciprocal relationship between biological and psychological processes.</p>","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"29 1-2","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12642457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A dynamic study of vanilmandelic acid elimination in the urine of divers in a dive at 21 ATA in saturation with a helium-oxygen respiratory mixture.","authors":"T D Mihăianu, O Popescu, G Badiu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this paper is a first assessment of the effect of stress agents specific for hyperbarism in professional divers. We selected the elimination of vanilmandelic acid (VMA) in the urine as an indicator. We studied four professional divers in a dive at 21 ATA. In order to assess the strain-induced by every distinct moment of the saturation profile we took samples of urine and determined VMA at four-hour intervals, before and after the distinct moment of saturation. The values found in the same four divers at the surface were used as \"controls\". VMA dosing in the urine proves to be a sensitive indicator for the assessment of stress and adaptive reactions during saturation.</p>","PeriodicalId":77362,"journal":{"name":"Revue roumaine de physiologie (Bucharest, Romania : 1990)","volume":"28 3-4","pages":"117-22"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}