Regional anesthesia最新文献_第10页

Monitoring epidural local anesthetic action during the postoperative period. 术后监测硬膜外局麻作用。

Regional anesthesia Pub Date : 1996-11-01

M J Lema

引用次数: 0

New agents to clinical practice: introduction to clinical trials. 新药临床应用:临床试验导论。

Regional anesthesia Pub Date : 1996-11-01

J C Eisenach

引用次数: 0

Can regional anesthesia worsen outcome? Medicolegal risk. 区域麻醉会使预后恶化吗?法医学的风险。

Regional anesthesia Pub Date : 1996-11-01

D J Wedel

引用次数: 0

Future epidural or subarachnoid analgesics: local anesthetics. 未来的硬膜外或蛛网膜下镇痛药:局部麻醉剂。

Regional anesthesia Pub Date : 1996-11-01

R L Carpenter

引用次数: 0

Cost-effectiveness and cost/benefit ratio of acute pain management. 急性疼痛治疗的成本效益和成本效益比。

Regional anesthesia Pub Date : 1996-11-01

R L Rauck

引用次数: 0

Saturable in vitro metabolism of articaine by serum esterases. Does it contribute to the persistence of the local anesthetic effect? 阿替卡因在体外通过血清酯酶的饱和代谢。它是否有助于局部麻醉效果的持续?

Regional anesthesia Pub Date : 1996-11-01

R Oertel, A Berndt, W Kirch

{"title":"Saturable in vitro metabolism of articaine by serum esterases. Does it contribute to the persistence of the local anesthetic effect?","authors":"R Oertel, A Berndt, W Kirch","doi":"","DOIUrl":"","url":null,"abstract":"Background and objectives: The amide-type local anesthetic articaine is unique in that hydrolysis to articainic acid by serum esterases is its main metabolic pathway. The purpose of the present investigation was to study the concentration dependence of this pathway in vitro.Methods: To unbuffered (pH 8.2) as well as phosphate-buffered (pH 7.4) heated serum samples were added various amounts of articaine in the range 10-300 micrograms/mL. Concentrations of articaine and articainic acid were measured by high-performance liquid chromatography after incubating the samples at 37 degrees C for intervals ranging from 5 minutes to 6 hours after addition of articaine.Results: The in vitro metabolism of articaine was shown to undergo pH-dependent Michaelis-Menten kinetics, indicating saturation at higher substrate concentrations. The Michaelis constant K(m) was determined as 175 micrograms/mL and 22.1 micrograms/mL and the maximum reaction rate Vmax as 2.1 micrograms/mL/min and 0.17 microgram/mL/min at pH 8.2 and pH 7.2, respectively. These results support previous in vivo observations that suggest saturable articaine metabolism, indicated by higher articaine/articainic acid metabolic ratio with higher articaine concentrations in alveolar blood after dental extraction.Conclusion: Local saturation of the serum esterases may contribute to the advantageous relationship between persistence of the local anesthetic effect and low systemic toxicity caused by the last systemic elimination of articaine (ie, its wide toxic therapeutic ratio).","PeriodicalId":77347,"journal":{"name":"Regional anesthesia","volume":"21 6","pages":"576-81"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19920863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subarachnoid neostigmine does not affect blood pressure or heart rate during bupivacaine spinal anesthesia. 在布比卡因脊髓麻醉期间，蛛网膜下腔新斯的明不影响血压或心率。

Regional anesthesia Pub Date : 1996-11-01

G R Lauretti, M P Reis

{"title":"Subarachnoid neostigmine does not affect blood pressure or heart rate during bupivacaine spinal anesthesia.","authors":"G R Lauretti, M P Reis","doi":"","DOIUrl":"","url":null,"abstract":"Background and objectives: Intraspinal administration of neostigmine has been shown to prevent induction of hypotension in rats by bupivacaine spinal block, and thus to provide greater hemodynamic stability. This study was undertaken to determine whether subarachnoid neostigmine would prevent bupivacaine spinal anesthesia from causing hypotension or bradycardia in patients undergoing abdominal hysterectomy.Methods: Of 40 patients scheduled for abdominal hysterectomy under spinal anesthesia, 20 were randomly assigned to each of two groups. The control group (CG) received 1.5 mL subarachnoid saline followed by 15 mg (3 mL) of hyperbaric bupivacaine 0.5%. The neostigmine group (NG) received 75 micrograms (1.5 mL) of subarachnoid neostigmine followed by 15 mg (3 mL) of hyperbaric bupivacaine 0.5%. No preload was given. Hypotension was treated with 4-mg intravenous boluses of ephedrine to keep blood pressure above 75% of the baseline value. The skin body temperature was measured with probes at the suprascapular region and at the foot.Results: Spinal neostigmine (75 micrograms) failed to prevent bupivacaine-induced hypotension. There was no statistical difference in the incidence of brady-cardia between the groups (NG, 2/20; CG 1/20), although the bradycardia appeared to be qualitatively different, being somewhat delayed in the NG. Spinal neostigmine did not alter the onset or duration of sensory block and did not affect skin body temperature in either anesthetized or unanesthetized sites. The incidence of intraoperative nausea was 20% in the NG and 5% in the CG.Conclusion: A 75-micrograms subarachnoid neostigmine dose does not affect blood pressure or heart rate during bupivacaine spinal anesthesia.","PeriodicalId":77347,"journal":{"name":"Regional anesthesia","volume":"21 6","pages":"586-91"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19920866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric axillary block with conscious sedation. 小儿腋窝阻滞加有意识镇静。

Regional anesthesia Pub Date : 1996-11-01

J O Margolis, A K Ross, S M Steele

引用次数: 0

Clinical outcome after epidural anesthesia and analgesia in high-risk surgical patients. 高危外科患者硬膜外麻醉镇痛后的临床效果。

Regional anesthesia Pub Date : 1996-11-01 DOI: 10.1136/RAPM-00115550-199621061-00033

D. Oa

引用次数: 11

Alternative neuraxial pain management techniques. 可选择的神经轴疼痛管理技术。

Regional anesthesia Pub Date : 1996-11-01

S E Abram

引用次数: 0