Perspectives on developmental neurobiology最新文献_第9页

The development of cholinergic sympathetic neurons: a role for neuropoietic cytokines? 胆碱能交感神经元的发育:神经生成细胞因子的作用?

Perspectives on developmental neurobiology Pub Date : 1996-01-01 DOI: 10.1080/0907676x.1996.9961274

S C Landis

引用次数: 28

Death in the balance. 生死未卜

Perspectives on developmental neurobiology Pub Date : 1996-01-01

A J Dibenedetto, R N Pittman

引用次数: 0

Morphogenesis of retinal ganglion cells: a model of dendritic, mosaic, and foveal development. 视网膜神经节细胞的形态发生:树突状、镶嵌状和中央凹发育的模型。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

M A Kirby, T C Steineke

引用次数: 0

Microglia in human retina: a heterogeneous population with distinct ontogenies. 人视网膜中的小胶质细胞:具有不同个体发生的异质群体。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

J M Provis, C M Diaz, P L Penfold

{"title":"Microglia in human retina: a heterogeneous population with distinct ontogenies.","authors":"J M Provis, C M Diaz, P L Penfold","doi":"","DOIUrl":"","url":null,"abstract":"Microglia of the adult human retina are a heterogeneous population of cells, some having characteristics of dendritic antigen presenting cells (DC) and others resembling macrophages, or MPS cells. Studies of the development of microglial distributions in human retina suggest that cells bearing macrophage markers are ontogenetically distinct from microglia that do not. Quantitative studies indicate that macrophage antigen immunoreactive microglia are a subpopulation CD45- and MHC-immunoreactive microglia. While CD45 and MHC-I and -II immunoreactive microglia are seen in the retina prior to the arrival of the vasculature, significant numbers of macrophage-positive microglia only arrive along with the vascular precursors, at about 14 to 15 weeks of gestation. Microglia appear to enter the retina from the ciliary margin prior to vascularization but from both the optic disc and ciliary margin, postvascularization. Macrophage antigen positive microglia enter the retina mainly via the optic nerve head. It is argued that macrophage-antigen positive microglia become established in the retina as vessel associated (perivascular and paravascular) microglia and that the MHC-positive, but macrophage-antigen negative microglia (representing DC), become established as the parenchymal, ramified microglia of adult retina.","PeriodicalId":77321,"journal":{"name":"Perspectives on developmental neurobiology","volume":"3 3","pages":"213-22"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19895125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The glypican family of heparan sulfate proteoglycans: major cell-surface proteoglycans of the developing nervous system. 硫酸肝素蛋白聚糖葡聚糖家族:发育中的神经系统的主要细胞表面蛋白聚糖。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

A D Lander, C S Stipp, J K Ivins

{"title":"The glypican family of heparan sulfate proteoglycans: major cell-surface proteoglycans of the developing nervous system.","authors":"A D Lander, C S Stipp, J K Ivins","doi":"","DOIUrl":"","url":null,"abstract":"The glypican family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans comprises four vertebrate members, glypican, cerebroglycan, OCI-5, and K-glypican, and the Drosophila protein, daily. These molecules share highly conserved protein structural features that sharply distinguish them from the syndecans, the other major class of cell surface heparan sulfate proteoglycans. All members of the glypican family are expressed in the developing nervous system, with one member (cerebroglycan) being restricted to that tissue. In the developing rodent brain, glypican and cerebroglycan--which appear to be the most abundant family members in that tissue--are expressed mainly by neurons, and both are strongly localized to axons. In the case of cerebroglycan, expression is limited to axons at or about the time they are extending toward their targets. Although the functions of the vertebrate members of this family are not known, in Drosophila, the effects of mutations in the daily gene suggest a role for members of the glypican family in regulating cell cycle progression during the transition of neural cells from proliferation to neuronal differentiation. It is likely that proteoglycans of the glypican family also play other important roles in neural development.","PeriodicalId":77321,"journal":{"name":"Perspectives on developmental neurobiology","volume":"3 4","pages":"347-58"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20065349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small GTPases in axon outgrowth. 轴突生长中的小gtp酶。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

L Luo, L Jan, Y N Jan

引用次数: 0

Intracellular mechanisms of axon growth induction by CAMs and integrins: some unresolved issues. cam和整合素诱导轴突生长的胞内机制:一些尚未解决的问题。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

J L Bixby, R J Bookman

引用次数: 0

Prevention of neuronal apoptotic death by neurotrophic agents and ganglioside GM1: insights and speculations regarding a common mechanism. 神经营养剂和神经节苷脂GM1预防神经元凋亡:关于共同机制的见解和推测。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

G Ferrari, L A Greene

{"title":"Prevention of neuronal apoptotic death by neurotrophic agents and ganglioside GM1: insights and speculations regarding a common mechanism.","authors":"G Ferrari, L A Greene","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this article is to present the concept that the capacity of ganglioside GM1 to promote neuronal survival, and probably other differentiative and neuroprotective actions, is dependent on activation of neurotrophic factor receptor tyrosine kinases. Exogenously supplied ganglioside GM1 mimics or potentiates many activities of neurotrophic factors, including maintenance of survival, stimulation of neurite outgrowth, and protection from excitotoxic and neurotoxic insults. The mechanism of such actions has been largely unknown. We have found that GM1 will rescue cultured sympathetic neurons and PC12 (pheochromocytoma) cells from apoptotic death induced by withdrawal of nerve growth factor (NGF) or serum and have exploited these model systems to study the ganglioside mechanism of action. We have found evidence that part of the survival-promoting activity of GM1 is dependent on the presence, dimerization, and activation of the Trk NGF receptor tyrosine kinase and that GM1 causes a detectable increase in Trk receptor autophosphorylation. We postulate that exogenously supplied GM1 causes increased ligand-independent dimerization of Trk molecules within membranes, thereby leading to its activation and promotion of survival. We further speculate that GM1 may have similar effects on other receptor tyrosine kinases and that such actions could account for its mimicry and potentiation of neurotrophic factors in vitro as well as in vivo.","PeriodicalId":77321,"journal":{"name":"Perspectives on developmental neurobiology","volume":"3 2","pages":"93-100"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19794554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic development in macaque monkey retina and its implications for other developmental sequences. 猕猴视网膜突触发育及其对其他发育序列的启示。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

A E Hendrickson

{"title":"Synaptic development in macaque monkey retina and its implications for other developmental sequences.","authors":"A E Hendrickson","doi":"","DOIUrl":"","url":null,"abstract":"New and existing data are presented regarding synaptic development in primate retina with the aims to identify the sequence in which individual cell types form synapses in the inner plexiform (IPL) and outer plexiform (OPL) layers; to compare synaptic development sequences in cone-dominated fovea and rod-dominated peripheral retina; to compare synaptic formation with other aspects of cell differentiation; and to explore the possible roles for synapses in development. The first synapses are formed in the foveal IPL by bipolar axons at fetal day 55, followed at fetal day 60 by cone ribbon synapses. Amacrine synapses in the foveal IPL only appear in significant numbers at fetal day 88. In peripheral retina amacrine synapses are formed at fetal day 78, bipolar at 99, and photoreceptors at 105. Thus, the fovea forms the first synapses and the IPL matures before the OPL across the retina, but the fovea has a different bipolar/amacrine sequence than peripheral retina. Foveal synapses are present before many photoreceptor-specific proteins such as opsins can be detected, suggesting that some phenotypic information from the inner retina could influence the direction of photoreceptor development. The early synaptic development in the fovea may serve an important mechanical role during subsequent cell migrations that form the mature foveal pit and tightly packed cone foveola.","PeriodicalId":77321,"journal":{"name":"Perspectives on developmental neurobiology","volume":"3 3","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19895123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versican. Versican。

Perspectives on developmental neurobiology Pub Date : 1996-01-01

R G Lebaron

引用次数: 0