Journal of trace elements and electrolytes in health and disease最新文献_第4页

Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats. 大鼠肝癌、胃癌、十二指肠癌和乳腺癌中铝的积累。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

K Ogoshi, S Yanagi, T Moriyama, H Arachi

{"title":"Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats.","authors":"K Ogoshi, S Yanagi, T Moriyama, H Arachi","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the present investigation was to evaluate abnormal changes in trace element concentrations during carcinogenesis. First, Al, Zn and Cu in the liver tissues of rats were measured by atomic absorption analysis over a half year of hepatocarcinogenesis. Male Wistar rats were given carcinogenic food containing 600 mg/kg of 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) in a basal diet for several months. After 4 to 6 months of feeding, hepatocarcinomas developed in the rats. Zn and Cu concentrations in the hepatocarcinomas of the 3'-MeDAB group significantly decreased as compared with normal liver tissues of the control groups. On the other hand, the aluminum concentration in the hepatocarcinomas was more than three times that in the normal liver tissues. The Al and Se contents of developed gastric and mammary cancers were measured in Experiment II. Male and female rats were given 1-methyl-3-nitrothoguanidine(MNNG) and 2,7-dimehtylbenz(a)anthracene(DMBA), respectively. After several months, carcinomas developed in over half of the rats. The Al and Se concentrations in cancers, livers and the blood were determined by atomic absorption analysis. It was shown that both gastric and mammary carcinomas contained a high level of aluminum and very little selenium in comparison with normal liver tissues. The present study demonstrated that aluminum accumulated in experimentally induced carcinomas in rats, i.e., cancers of the liver, stomach, duodenum and mammary glands.","PeriodicalId":77233,"journal":{"name":"Journal of trace elements and electrolytes in health and disease","volume":"8 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18806858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultramicroanalysis of dental plaque films by total reflection X-ray fluorescence. 全反射x射线荧光法对牙菌斑膜的超微分析。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

A von Bohlen, P Rechmann, J L Tourmann, R Klockenkämper

引用次数: 0

Incidence of subclinical lead (Pb) exposure in cattle of an industrial area in Greece. 希腊某工业区牛亚临床铅暴露的发生率。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

Z Polizopoulou, N Roubies, H Karatzias, A P Papasteriades

引用次数: 0

Protein technics for selenium speciation in human body fluids. 体液中硒形成的蛋白质技术。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

P D Whanger, Y Xia, C D Thomson

引用次数: 0

Experimental model of lead nephropathy. IV. Correlation between renal functional changes and hematological indices of lead toxicity. 铅肾病的实验模型。四、肾功能变化与铅中毒血液学指标的相关性。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

F Khalil-Manesh, J Tartaglia-Erler, H C Gonick

{"title":"Experimental model of lead nephropathy. IV. Correlation between renal functional changes and hematological indices of lead toxicity.","authors":"F Khalil-Manesh, J Tartaglia-Erler, H C Gonick","doi":"","DOIUrl":"","url":null,"abstract":"Adverse effects on hematopoiesis and renal function have been reported in both animals and humans exposed to high doses of lead for a protracted period of time, but little is known about the interrelationship between these two target organ systems. The present study examines rats exposed via drinking water to high dose (5000 mg/L) or low dose (100 mg/L) lead, either continuously or discontinuously, for periods ranging from 1 to 12 months. In addition to blood lead, indices of hematological abnormalities included hematocrit, zinc protoporphyrin (ZPP) and red blood cell (RBC) membrane sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase). Renal function abnormalities were assessed by measurements of glomerular filtration rate (GFR) by the single injection 125-I-iothalamate technique and urinary excretion of the proximal renal tubular enzyme, ligandin. Blood lead and GFR correlated positively during the first 6 months of lead administration, reflecting a stimulatory effect of lead on renal hypertrophy and GFR during this time period. When this distorting effect was factored out, there were few residual correlations between renal and hematological abnormalities. The only significant relationship between GFR and hematological parameters of lead toxicity was a negative correlation between GFR and RBC membrane Na-K-ATPase in animals treated with high dose lead for 6 months and observed at the end of 12 months (discontinuous group).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77233,"journal":{"name":"Journal of trace elements and electrolytes in health and disease","volume":"8 1","pages":"13-9"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18806856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium concentration in plasma and erythrocytes in a healthy Slovak population. 斯洛伐克健康人群血浆和红细胞中的硒浓度。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

A Madaric, J Kadrabová, E Ginter

引用次数: 0

Trace element concentrations in hair of subjects from two South Pacific Islands, Atafu (Tokelau) and Kitava (Papua New Guinea). 来自两个南太平洋岛屿Atafu(托克劳)和Kitava(巴布亚新几内亚)的受试者头发中的微量元素浓度。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

T S Srikumar, A Källgård, S Lindeberg, P A Ockerman, B Akesson

{"title":"Trace element concentrations in hair of subjects from two South Pacific Islands, Atafu (Tokelau) and Kitava (Papua New Guinea).","authors":"T S Srikumar, A Källgård, S Lindeberg, P A Ockerman, B Akesson","doi":"","DOIUrl":"","url":null,"abstract":"The concentrations of trace elements in hair were measured in 108 healthy subjects (60 males and 48 females, mean age 46-years) resident on Atafu (Tokelau) and in 83 subjects (63 males and 20 females, mean age 26-years) living on Kitava island (Papua New Guinea). On Kitava, a traditional subsistence lifestyle uninfluenced by Western dietary habits is still maintained, but on Atafu the dietary habits have been modified by the inclusion of such imported foods as rice, flour, sugar and canned meat and fish. The concentrations of zinc and magnesium in hair were significantly higher in the Kitava than in the Atafu subjects, whereas those of copper were similar in both groups, and those of selenium, mercury, lead and cadmium were higher in Atafu subjects. The levels of serum copper, magnesium and selenium concentrations in Kitava subjects were not so low as to indicate any trace element deficiency. The higher hair content of mercury, lead and cadmium found among Atafu subjects might be due to consumption of marine foods contaminated with metals, consumption of canned foods, or frequent cigarette smoking, though it is difficult to single out any specific factor.","PeriodicalId":77233,"journal":{"name":"Journal of trace elements and electrolytes in health and disease","volume":"8 1","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18806857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ontogenic changes in the nephrotoxicity of chromate correlate with the glutathione oxidoreduction system. 铬酸盐肾毒性的个体变化与谷胱甘肽氧化还原系统有关。

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

D Appenroth

引用次数: 0

Selenium status in Turkey. II. Serum selenium concentration in healthy residents of different ages in Ankara. 土耳其的硒状况。2安卡拉不同年龄健康居民血清硒浓度

Journal of trace elements and electrolytes in health and disease Pub Date : 1994-03-01

F Hincal, N Başaran, S Yetgin, O Gökmen

引用次数: 0

Trace element content of human milk during lactation. 母乳中微量元素的含量。

Journal of trace elements and electrolytes in health and disease Pub Date : 1993-12-01

L Perrone, L Di Palma, R Di Toro, G Gialanella, R Moro

引用次数: 0