Journal of immunotherapy : official journal of the Society for Biological Therapy最新文献_第2页

Induction of circulating phospholipase A2 activity by intravenous infusion of endotoxin in patients with neoplasia. 静脉输注内毒素诱导肿瘤患者循环磷脂酶A2活性的研究。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-11-01 DOI: 10.1097/00002371-199211000-00004

W Pruzanski, A Mackensen, R Engelhardt, E Stefanski, P Vadas

{"title":"Induction of circulating phospholipase A2 activity by intravenous infusion of endotoxin in patients with neoplasia.","authors":"W Pruzanski, A Mackensen, R Engelhardt, E Stefanski, P Vadas","doi":"10.1097/00002371-199211000-00004","DOIUrl":"https://doi.org/10.1097/00002371-199211000-00004","url":null,"abstract":"The purpose of this study was to evaluate the impact of repeated intravenous infusions of endotoxin (EN) in patients with cancer on the systemic release of extracellular proinflammatory phospholipase A2 (PLA2) and its relationship to the release of tumor necrosis factor (TNF) and interleukin-6 (IL-6). Six patients received 15 infusion of EN isolated from Salmonella abortus equi at a dose of 4 ng/kg. Marked increase in the activity of circulating PLA2 was noted within 3 h after the first EN infusion and reached a maximal level of 20.4-fold greater than baseline 24 h after infusion. In five patients challenged with EN 2 weeks later, PLA2 reached peak levels 15.5-fold greater than baseline. In two patients who received three sequential daily infusions, the incremental increase in PLA2 activity after the second and third challenge reached maximum levels 6 h after EN infusion. PLA2 response followed those of TNF and IL-6 but was quantitatively different. Whereas maximal levels of TNF and IL-6 declined substantially after repeat EN challenges, no such decline occurred in PLA2 activity. Since, in the clinical setting of gram-negative sepsis, there is recurrent increase in circulating EN, our study approximates this clinical situation and shows that extracellular release of PLA2 follows temporally that of proximal cytokines such as TNF and IL-6. These cytokines may be related to PLA2 release and sustained high activity in the systemic circulation.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 4","pages":"242-6"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199211000-00004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12646439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Sequential chemotherapy and immunotherapy for the treatment of metastatic melanoma. 序贯化疗和免疫疗法治疗转移性黑色素瘤。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-11-01 DOI: 10.1097/00002371-199211000-00008

L M Schuchter, J Wohlganger, E K Fishman, M L MacDermott, W P McGuire

{"title":"Sequential chemotherapy and immunotherapy for the treatment of metastatic melanoma.","authors":"L M Schuchter, J Wohlganger, E K Fishman, M L MacDermott, W P McGuire","doi":"10.1097/00002371-199211000-00008","DOIUrl":"https://doi.org/10.1097/00002371-199211000-00008","url":null,"abstract":"Interferon (IFN) has numerous biological properties, and more recently a new role for interferon has emerged, as a modulator of cytotoxic chemotherapeutic agents. This is based upon preclinical data that demonstrate additive and/or synergistic effects of IFN with a number of anticancer drugs including cisplatin against human cancer cell lines. Therefore, we evaluated the outpatient use of recombinant alpha 2a-interferon, 3-15 MU/m2 given on 3 consecutive days, subcutaneously, followed by intravenously administered cisplatin, 25-60 mg/m2, every 21 days. In this phase I clinical study, 23 patients with advanced malignant melanoma were treated. Dose-limiting toxicities included decline in performance status, fatigue, and anorexia. No synergistic or unpredictable toxicities were seen. Of the 20 patients who completed two cycles of therapy, there were three partial responses, for an overall response rate of 15%. Interestingly, responses occurred at the intermediate dose levels.","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 4","pages":"272-6"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199211000-00008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12646442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The preferential expansion of functional CD4+ lymphocyte populations in vitro. 体外功能CD4+淋巴细胞群的优先扩增。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-11-01 DOI: 10.1097/00002371-199211000-00006

R M Townsend, P Simon

{"title":"The preferential expansion of functional CD4+ lymphocyte populations in vitro.","authors":"R M Townsend, P Simon","doi":"10.1097/00002371-199211000-00006","DOIUrl":"https://doi.org/10.1097/00002371-199211000-00006","url":null,"abstract":"We describe a simple and inexpensive chemical procedure for the selective expansion of human CD4+ lymphocytes. The method employs L-leucine methyl ester (LME) to deplete monocytes and large granular lymphocytes, as well as to inhibit growth of CD8+ lymphocytes. LME treatment eliminates granular cells, but most CD8+ lymphocytes, B-lymphocytes, and CD4+ lymphocytes remain. Peripheral blood mononuclear cells (PBMCs) from normal and HIV-positive individuals are treated with LME for 1 h at ambient temperature and cultured in the presence of IL-2 to expand the cell number. Stimulation with the T-cell mitogens concanavalin A, phytohemagglutinin, or OKT3 antibody augments lymphocyte expansion and within 1-3 weeks the culture is greatly enriched (90-100%) in CD4+ lymphocytes. LME-treated lymphocytes expand up to 10-fold during culture in the presence of IL-2 alone and up to 400-fold following treatment with T-cell mitogens. The immune function of LME-treated and expanded peripheral blood lymphocytes was examined using the response to the recall antigens tetanus toxoid and Candida albicans. Fresh PBMCs exposed to these recall antigens proliferated readily. Similarly, LME-treated lymphocytes following expansion responded to these recall antigens with good fidelity to the original PBMC response patterns in four of six donors. The expanded and LME-treated lymphocytes also exhibited good mitogen responses in three of three donors. The LME procedure allows for the simple and inexpensive generation of expanded, immunologically functional, CD4+ lymphocytes.","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 4","pages":"256-64"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199211000-00006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12534184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives. 黄酮-4-乙酸衍生物诱导细胞因子及与白细胞介素-2协同治疗小鼠肾癌和结肠癌。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-11-01 DOI: 10.1097/00002371-199211000-00005

H Futami, L Eader, T T Back, E Gruys, H A Young, R H Wiltrout, B C Baguley

{"title":"Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives.","authors":"H Futami, L Eader, T T Back, E Gruys, H A Young, R H Wiltrout, B C Baguley","doi":"10.1097/00002371-199211000-00005","DOIUrl":"https://doi.org/10.1097/00002371-199211000-00005","url":null,"abstract":"Derivatives of xanthenone-4-acetic acid (XAA) have been found to have similar activity to flavone-8-acetic acid against transplantable solid tumors. Some of these compounds were compared to flavone acetic acid (FAA) in their ability to induce cytokines as well as to mediate antitumor effects against murine renal cancer (Renca) and a mouse colon cancer (MCA-38). 5-Methyl-XAA and 5-chloro-XAA proved to be more potent than FAA on a mg/kg basis for induction of the genes for IFN alpha, IFN gamma, and TNF alpha, and for IFN and TNF activities in the sera of treated mice. These effects were sharply dose dependent. On the other hand, 7-methyl-XAA, which has no antitumor activity, did not induce these genes. In addition, 5-methyl-XAA and 5-chloro-XAA but not 7-methyl-XAA synergized with recombinant human interleukin-2 (rhIL-2) for the treatment of Renca and MCA-38. Doses of the active derivatives that failed to induce cytokines also exhibited no therapeutic synergy with rhIL-2. These results suggest that at least some of the antitumor effects of these XAA derivatives are related to their ability to induce cytokines.","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 4","pages":"247-55"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199211000-00005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12646440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells. 基因表达的反义抑制:研究NMYC在神经外胚层来源细胞生长和分化中的作用的工具。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-10-01 DOI: 10.1097/00002371-199210000-00003

L M Neckers, A Rosolen, L Whitesell

引用次数: 14

Natural regulators of T-cell lymphokine production in vivo. 体内t细胞淋巴因子产生的天然调节因子。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-10-01 DOI: 10.1097/00002371-199210000-00006

R A Daynes, B A Araneo

{"title":"Natural regulators of T-cell lymphokine production in vivo.","authors":"R A Daynes, B A Araneo","doi":"10.1097/00002371-199210000-00006","DOIUrl":"https://doi.org/10.1097/00002371-199210000-00006","url":null,"abstract":"The mammalian immune system possesses the intrinsic capacity to evoke a wide variety of functionally distinct effector mechanisms following stimulation by a particular antigenic substance. Such diversity in available responses is absolutely essential to the immunocompetent host, which must continually deal with a diverse set of potential pathogens within its ever-changing environment. The development of appropriate types of immune responses, therefore, represents a highly dynamic process that requires that an equivalent consideration be given to a large array of components, any one of which is capable of modulating the final outcome. While the nature and complexity of the antigen(s), plus the intracellular or extracellular mode of presentation, provide specificity and some selection to the developing process, the route of antigen entry, as well as the physiological status of the host at the time of antigen insult, also contribute significantly to the formation of any immune response. The overall objective of this article is to introduce the concept that platelet-derived growth factor (PDGF) (either preformed or synthesized in response to stimulation), plus a number of steroid hormones (some of which are end-organ metabolized at local tissue sites), can all play significant roles in the genesis of immunologic responses in vivo.","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 3","pages":"174-9"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199210000-00006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12616274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

The use of congenitally immunodeficient mice to study human tumor metastases and immunotherapy. 利用先天性免疫缺陷小鼠研究人类肿瘤转移和免疫治疗。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-10-01 DOI: 10.1097/00002371-199210000-00011

J J Mulé, D L Jicha, S A Rosenberg

{"title":"The use of congenitally immunodeficient mice to study human tumor metastases and immunotherapy.","authors":"J J Mulé, D L Jicha, S A Rosenberg","doi":"10.1097/00002371-199210000-00011","DOIUrl":"https://doi.org/10.1097/00002371-199210000-00011","url":null,"abstract":"Congenitally immunodeficient strains of mice have proven valuable in the development of relevant models to study human tumor biology, metastases, and immunotherapy. Local invasion and extensive multiorgan metastases in athymic mice have been obtained following orthotopic implantation or onplantation of histologically intact fragments of human tumors. In C.B-17 severe combined immunodeficient (SCID) mice or in triple immunodeficient, beige/nude/xid (BNX) mice, the development and spread of inoculated human leukemia/lymphoma and/or melanoma have mimicked, in some cases, those observed in patients. Reports of reconstitution of SCID and BNX mice with human myeloid or lymphoid cells have suggested that these models might be useful for the study of human immune responses to autologous tumors in vivo. The severe immunocompromised status of these mice have also led to evaluations of the therapeutic efficacy of adoptively transferred, tumor-reactive human T cells. In this report, we review the pertinent information currently available on the use of congenitally immunodeficient mice in studies of human cancer biology and treatment.","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 3","pages":"196-8"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199210000-00011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12617375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Presentation of three different viral peptides is determined by common structural features of the human lymphocyte antigen-A2.1 molecule. 三种不同病毒肽的呈现是由人淋巴细胞抗原a2.1分子的共同结构特征决定的。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-10-01 DOI: 10.1097/00002371-199210000-00007

U Utz, W E Biddison

{"title":"Presentation of three different viral peptides is determined by common structural features of the human lymphocyte antigen-A2.1 molecule.","authors":"U Utz, W E Biddison","doi":"10.1097/00002371-199210000-00007","DOIUrl":"https://doi.org/10.1097/00002371-199210000-00007","url":null,"abstract":"To assess whether similar or dissimilar molecular features of class I human lymphocyte antigen (HLA) molecules determine the presentation of structurally diverse peptides, we have examined the influence of different pockets within the HLA-A2.1 molecule on the presentation of three different viral peptides. The influenza virus M1 58-66, HTLV-I Tax peptide 12-19, and HCMV gB 619-628 are minimal peptides that induce HLA-A2.1-restricted non-cross-reactive CTL responses. The influence of distinct structural features of HLA-A2.1 on peptide presentation was analyzed using a panel of 14 HLA-A2 mutants each with single amino acid substitutions in one of six pockets that are located in the peptide binding site. Ten of the 14 mutants showed concordant effects on the presentation of all three peptides to their peptide-specific CTL lines. Four of the mutants had a negative effect on the presentation of only one or two of these viral peptides. These findings indicate that common structural features in HLA-A2 determine the binding and conformation of different peptides, and help to provide a plausible explanation for how diverse peptides bind to HLA-A2.","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 3","pages":"180-2"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199210000-00007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12616275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Use of T-cell growth factors (interleukins 2, 4, 7, 10, and 12) in the evaluation of T-cell reactivity to melanoma. 使用t细胞生长因子(白细胞介素2、4、7、10和12)评估t细胞对黑色素瘤的反应。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-10-01 DOI: 10.1097/00002371-199210000-00015

M T Lotze, H J Zeh, E M Elder, Q Cai, B A Pippin, M M Rosenstein, T L Whiteside, R Herberman

{"title":"Use of T-cell growth factors (interleukins 2, 4, 7, 10, and 12) in the evaluation of T-cell reactivity to melanoma.","authors":"M T Lotze, H J Zeh, E M Elder, Q Cai, B A Pippin, M M Rosenstein, T L Whiteside, R Herberman","doi":"10.1097/00002371-199210000-00015","DOIUrl":"https://doi.org/10.1097/00002371-199210000-00015","url":null,"abstract":"Melanoma represents the single best example of a human tumor that has been shown to elicit specific T-cell reactivity. The responsiveness of some patients with metastatic melanoma to treatment with the prototypic T-cell growth factor (TCGF), interleukin-2 (IL-2), indicates that T cells play a role in antitumor immunity. Interleukin-4 (IL-4), another TCGF that has been administered clinically to humans, was not associated with tumor response in our trials conducted at the Surgery Branch of the National Cancer Institute. Combination trials of IL-2 with IL-4 have shown no increase in responsiveness of melanoma or other tumors when compared to IL-2 alone. However, enhanced expansion of tumor-infiltrating lymphocytes (TILs) in vitro has been observed with combinations of low-dose IL-2 and IL-4. We have begun a study evaluating the trafficking of such expanded lymphocytes following their adoptive transfer in association with systemic administration of IL-2 and IL-4. We have established several TIL cultures from fresh tumor samples, maintained them in long-term culture, and marked them with the neomycin phosphotransferase gene using the LNL6 retroviral vector. Such TILs appear to demonstrate no notable alterations in phenotype or cytolytic activity when compared to their nontransduced counterparts. In addition to IL-2 and IL-4, there are a variety of other novel TCGFs that are now available for evaluation in preclinical and clinical trials. IL-7 induces proliferation and lymphokine-activated killer (LAK) cell activity from human peripheral blood mononuclear cells.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77209,"journal":{"name":"Journal of immunotherapy : official journal of the Society for Biological Therapy","volume":"12 3","pages":"212-7"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00002371-199210000-00015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12532615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Interactions of cytokines with the hypothalamus-pituitary axis. 细胞因子与下丘脑-垂体轴的相互作用。

Journal of immunotherapy : official journal of the Society for Biological Therapy Pub Date : 1992-10-01 DOI: 10.1097/00002371-199210000-00005

L C Payne, J M Krueger

引用次数: 14