{"title":"Proceedings of the 38th scientific session, Japanese College of Cardiology. Hiroshima, October 4-6, 1990. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"27 ","pages":"1-351"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12910275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Collagen remodeling of a mitral periannular cardiac muscle lesion in experimental mitral regurgitation rabbits induced by vagus stimulation].","authors":"S Naito, K Imataka, Y Seko, J Fujii","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A peculiar mitral periannular cardiac muscle lesion was developed in experimental mitral regurgitation rabbits induced by vagus stimulation. In this model, a pansystolic murmur was heard during one week after vagus stimulation, and it disappeared thereafter. We investigated the periannular cardiac muscle lesion one week (MR-1 group, N = 30) and four weeks (MR-4 group, N = 15) after vagus stimulation using pathohistological, immunohistochemical and biochemical techniques, and found that the lesion had regressed in four weeks. Non-treated rabbits (C-1 group and C-4 group) were used as controls. The periannular cardiac muscle lesion in MR-1 group was characterized by swelling and increased stiffness which corresponded to swelling and degeneration of the myocardial cells and interstitial fibrosis on microscopic observation. On the other hand, in MR-4 group, the swelling and degeneration of the myocardial cells restored and an increase of interstitial collagen was regressed. The hydroxyproline content of the periannular cardiac muscle lesion in MR-1 group was significantly abundant compared with that in C-1 group (10.5 +/- 1.6 mg/g. wet wt, vs 7.8 +/- 0.9, mean +/- SD, p less than 0.01). In MR-4 group, the hydroxyproline content was significantly decreased compared with that in MR-1 group (8.8 +/- 1.4 vs 10.5 +/- 1.6, p less than 0.05). Immunohistochemical study clearly indicated that the increased collagen in the periannular cardiac muscle lesion in MR-1 group was type III collagen, and that the increased type III collagen regressed in MR-4 group.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"25 ","pages":"53-9, discussion 60-1"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12992887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Four boys with multiple floppy valves involving all cardiac valves and hyperextensive joints].","authors":"K Suzuki, Y Murakami, K Mori, S Mimori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We experienced four boys (two siblings) whose cardiac valves were all prolapsed, which have never been reported as a recognized disease. All had hyperextensive joints without any other stigmata of Marfan or Ehlers-Danlos syndrome. The severity and progression of regurgitation of each valve differed by a case, though they had similar echocardiographic findings consistent with the diagnosis of multiple floppy valves. Three of the four patients had severe aortic regurgitation, and two received aortic valve replacement. Their excised valves revealed myxomatous degeneration. The tricuspid valves were more thickened and redundant than the mitral valves. Although three patients had moderate tricuspid regurgitation, none of them had clinically important mitral regurgitation. We recommend aortic and/or mitral valve replacement, whenever the regurgitation exacerbates left ventricular dilatation. Aortic regurgitation deteriorated rapidly in one case due to valve rupture. In this case, moderate tricuspid regurgitation was relieved after aortic valve replacement. Skin fibroblast did not show any abnormalities in collagen biosynthesis.</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"25 ","pages":"161-72; discussion 173-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13049097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Ono, M Matsuzaki, H Michishige, Y Wasaki, Y Tomochika, K Murata, I Tokisawa, Y Nishimura, F Okuda, R Kusukawa
{"title":"[Estimation of atherosclerotic lesions in the thoracic aorta by transesophageal echocardiography].","authors":"S Ono, M Matsuzaki, H Michishige, Y Wasaki, Y Tomochika, K Murata, I Tokisawa, Y Nishimura, F Okuda, R Kusukawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The thoracic aorta is one of the portions frequently involved with atherosclerotic lesions. We estimated atherosclerotic lesions in the thoracic aorta in consecutive 137 patients (59 +/- 10 years old) using transesophageal echocardiography. The study population consisted of 60 with coronary artery disease (CAD), 36 with hypertension (HT), 28 with hypercholesterolemia (HC, total cholesterol greater than or equal to 230 mg/dl), eight with dissecting aneurysm, nine with true aneurysm and two with aortitis syndrome. We used a single transverse scan-plane probe with ultrasound frequency of 5 MHz. We could obtain satisfactory echograms of whole thoracic aorta except upper portion of the ascending aorta. We defined atherosclerotic lesions as an increased echo-density of the intima, protruded plaque, ulceration or aneurysm. Atherosclerotic lesions were observed in 71 of 137 patients (52%). High incidence of the atherosclerotic lesions was seen in patients with HT (72%), HC (57%) and CAD (57%), whereas incidence of atherosclerotic lesions was low (15%) in patients without HT, HC, CAD or aortic aneurysm. Atherosclerotic lesions were observed more frequently in patients aged greater than or equal to 60 years (69% vs 34%, p less than 0.001). In patients with HT or HC, atherosclerotic lesions were frequently observed even in patients younger than 60 years old (HT: 58%, HC: 53%). We concluded that HT, HC and aging were important risk factors for the atherosclerotic process in the thoracic aorta, and transesophageal echocardiography was a useful approach for the detailed estimation of atherosclerotic lesions in the thoracic aorta.</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"26 ","pages":"57-67"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13090726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Usefulness of high resolution transesophageal echocardiography for diagnosis of ruptured chordae tendineae of the mitral valve: clinical and echocardiographic characteristics].","authors":"S Yoshida, O Iimura, K Hirata, M Fukuda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Transesophageal echocardiography with high resolution (TEE; 5 MHz, convex type probe) revealed ruptured chordae tendinae of the mitral valve (RCT) in seven patients. However transthoracic echocardiography (TTE) was diagnostic only in two patients. These all seven patients had mitral valve prolapse and mitral regurgitation documentated by TTE. Six of seven patients were 59 years or older, and four patients had only mild symptoms. TEE showed the systolic appearance of an edge echo, suggesting an edge of ruptured chordae tendineae within the left atrium. These results show that TEE is a useful method for detecting RCT of the mitral valve, especially in the aged patients with MVP and mitral regurgitation. It is because of the availability of high resolution and nearfield in TEE.</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"26 ","pages":"69-74"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13090727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y Okano, S Nagata, F Ishikura, N Asaoka, S Beppu, F Ohmori, J Tamai, K Miyatake
{"title":"[Progression of idiopathic mitral valve prolapse estimated by echocardiography].","authors":"Y Okano, S Nagata, F Ishikura, N Asaoka, S Beppu, F Ohmori, J Tamai, K Miyatake","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To evaluate the progression of idiopathic mitral valve prolapse (MVP), a long time follow-up study (mean 7.1 years) was performed using echocardiography in 27 cases (11 males, 16 females, mean age: 50.4 years). Morphological changes, the degree of prolapse of the mitral valve, left atrial dimension (LAD) and left ventricular end-diastolic dimension (LVDd) were estimated at the first and last examinations. The degree of prolapse was assessed by measuring the distance of the dislocation between the anterior and posterior leaflets at the area of coaptation (degree I:5 mm or less, degree II: 6 to 10 mm, degree III: 11 mm or greater). The results were as follows: 1. The degree of prolapse did not progress in all 27 cases. 2. LAD increased with an advance of age. A remarkable increase of LAD was recorded in cases older than 45 years with atrial fibrillation or prolapse of degree II and III or with ruptured chordae tendineae. 3. The mitral ring was enlarged over 5 mm in six of 15 cases with prolapse of degree II and III. 4. Mitral regurgitation evaluated by Doppler echocardiography in patients with posterior leaflet prolapse was more severe than that in patients with anterior leaflet prolapse in the last examination. 5. LVDd increased gradually. In the present study, LAD was increased in most cases of MVP and it seemed to depend on complications (atrial fibrillation and ruptured chordae tendineae) or severity of regurgitation rather than the degree of prolapse.</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"23 ","pages":"73-9; discussion 80-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13546760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Sugiura, S Ohkawa, C Watanabe, A Toku, T Imai, K Kuboki, H Shimada
{"title":"[Morphological observation of the mitral annulus fibrosus in patients with mitral valve prolapse].","authors":"M Sugiura, S Ohkawa, C Watanabe, A Toku, T Imai, K Kuboki, H Shimada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sixteen cases of mitral valve prolapse (MVP) with mitral regurgitation (MR) in the aged (mainly in their eighth and ninth decades) with both clinical and pathological evidences were investigated. One hundred autopsy cases served as the control. The longitudinally-sectioned mitral annulus fibrosus was pathologically studied in all with special reference to the atrium-valve disjunction reported by Hutchins. Morphologically, the mitral annulus fibrosus was classified either as type A (the mitral valve attaches to the left ventricle), type B (the mitral valve attaches to the left atrium: Hutchins' disjunction), type C (the atrialis continues to the left atrium and the fibrosa to the left ventricle), or type D (mitral annulus calcification). Type B was observed in only 31% of the MVP cases, whereas it was seen in 43% of the control cases. It was concluded that Hutchins' observation could not be regarded as the characteristic pathological finding of MVP.</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"23 ","pages":"21-8; discussion 29-30"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13546757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitral valve prolapse vs mitral valve prolapse syndrome: what is the difference?","authors":"P M Shah","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"23 ","pages":"3-19"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13356282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Peculiar mitral periannular cardiac muscle lesion in rabbits with experimentally-induced mitral regurgitation by vagus stimulation: investigation of a collagen increase and a myosin heavy chain isozyme change].","authors":"S Naito, K Imataka, Y Seko, J Fujii","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A peculiar mitral periannular cardiac muscle lesion was developed in rabbits with experimentally-induced mitral regurgitation by vagus stimulation. We investigated the cardiac muscle lesion of mitral regurgitation rabbits (MR group, N = 30) using pathohistological, immunohistochemical and biochemical methods. Control group consisted of 21 non-treated rabbits. The periannular cardiac muscle lesion in the MR group was characterized by swelling and increased stiffness of the muscle which were observed as swelling and degeneration of the myocardial cells and interstitial fibrosis on the microscopic observation, and increase in the amount and dimension of collagen tendon, strands, and struts on the scanning electron microscopic study. Hydroxyproline content of the periannular cardiac muscle lesion in the MR group was significantly abundant compared with that in the control group (10.5 +/- 1.6 vs 7.8 +/- 0.9 mg/g.wet wt, mean +/- SD, p less than 0.01) and that of the cardiac muscle in the left ventricular free wall in the MR group (10.5 +/- 1.6 vs 7.1 +/- 0.9, p less than 0.01). Furthermore, the immunohistochemical study clearly indicated that the increased collagen in the periannular cardiac muscle lesion in the MR group was type III collagen. A significant myosin heavy chain isozyme change from V1 myosin to V3 myosin on pyrophosphate gel electrophoresis was observed at the periannular cardiac muscle lesion in the MR group compared with that in the control group (%V1: %V3, 4.2: 92.7 vs 15.4: 74.7, p less than 0.01) and that of the cardiac muscle in the left ventricular free wall in the MR group (4.2: 92.7 vs 14.1: 75.4, p less than 0.01). These results suggested that the mitral periannular cardiac muscle in experimental mitral regurgitation rabbits induced by vagus stimulation suffers a strong mechanical load compared with the cardiac muscle in the left ventricular free wall.</p>","PeriodicalId":77193,"journal":{"name":"Journal of cardiology. Supplement","volume":"23 ","pages":"31-45; discussion 46"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13298419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}